Irum Khan
@Irumkhan_hem
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acute and chronic myeloid malignancies - clinical and translational research
Northwestern University
Joined December 2017
Really exciting to see the clinical culmination of your group’s earlier observations on BET inhibition potentiating JAK inhibitors in inflammation suppression in MF. Valuable clinical efficacy data in a disease where combination therapies are challenging.
Out today in @NatureMedicine phase 3 data from thh MANIFEST-2 study @mpndoc @KuykendallMd @bose_prithviraj @harrisoncn1 @mpdrc @Vikas_Gupta_1 .Thread below.
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Thank you Dr Grant for an insightful discussion on the multilevel barriers to stem cell transplant, highlighting the sobering statistics of persistent disparities and policy level changes that are needed to ensure equitable access to this key arm of leukemia therapy.
🎧 Join @ShakiraG_MBBS and @Irumkhan_hem to explore the fascinating history and evolution of stem cell transplants. Learn about barriers to access and potential policy-level solutions. Listen: #MedTwitter #BMTsm #HealthEquity #BlackHistoryMonth
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HbSS outcomes in LMIC, tolerability of novel agents in URMs and neighborhood effects on leukemia-outstanding talks by the Hematology Inclusion Pathway trainees. Great discussion by alumni and mentors #ASH24 @UICDom @UICancerCenter
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Thank you for your efforts in leading this innovative work @Anand_88_Patel and @andrewthepalmer !.
The final version of our @BloodAdvances paper looking at air pollutant exposure in AML is out! Kudos to first author @andrewthepalmer .
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RT @AkEisfeld: So excited for the event co-hosted by @LeeGrimesLab with the most amazing people coming from across the country to share the….
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Fantastic line up @btfoundation #SCHD24 . 1-valuable trial implementation lesson from early covid trials to account for slower rate of BIPOC accrual due to access issues .2-effective communication around gender identity, race and ethnicity is first step to a therapeutic alliance.
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RT @KMirza: Incredible talk by Dr. Michele Andrasik about unpacking #disparities to inform action at #SCHD24 @btfoundation - take note of t….
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A prospective approach linking individual level pt reported SDOH data to early adverse AML outcomes. Proud of @EshanaShahMD for an excellent oral abstract and the dedicated efforts of leukemia teams, trainees and patients @UICancerCenter and @LurieCancer
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Congratulations! Linking macroenvironment to cancer outcomes is so challenging. thank you for sharing! I am going to town with my highlighter 😀….
Glad to be a part of the remarkable work published in @Nature by Hao Fan, Jing Chen et al! Trans-vaccenic acid may have implications for many of the T-cell mediated therapies (like blinatumomab as tested in this paper) we utilize in heme malignancies!.
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Honored to continue our teamwork to establish a link between social and physical environment and #AML biology and outcomes. @Anand_88_Patel @UChicagoLeuk @cgalve8 @UICancerCenter Dr. Tsai @LoyolaOnc @jaltmanmd @LurieCancer Dr. Larson @RushCancer & Dr. Zia @CookCountyIMR.
Announcement❗️.@chicagochec is pleased to announce its 2023 Catalyst & Incubator Grant Recipients. Both investigative teams have proposed novel approaches to addressing cancer disparities & are devoted to advancing cancer health equity. Learn more:
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Exciting collab w DrTyner @OHSUKnight and @UICancerCenter leveraging BeatAML data to show FOXM1 underlies chemosensitivty in NPM1mut AML and investigating a novel FOXM1 inhibitor @ACS_Research @LurieCancer
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Important work showing us that dogmatic clinical trial eligibility criteria need to be individually re-examined in the interest of inclusivity. Thank you @ahantel for including us.
Grateful to be a part of this important effort led by Dr Andrew Hantel re the heterogeneity found in phase II/III trials for acute leukemia! @LuskinMarlise @Irumkhan_hem .
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Looking forward to a great exchange of practice points and experiences in managing myeloid malignancies from a global oncology perspective. @LurieCancer @ACS_Research.
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RT @Lachelle_Dawn: It’s finally here! 🥹 . Thanks to my collaborators @abhinrl @LuskinMarlise @ColemanLindsley @c_j….
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RT @KatieLaiMD_MPH: Thanks @JazzPharma for sponsoring the inaugural Women in Leukemia event! And thank you to the women AND men who came ou….
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Fascinating animal data from @profshanecrotty that unbeknownst to us, memory b cells are training to become 1000 fold more potent against antigenic variants in germinal center arsenals upto 6 months after vaccine exposure #ASH2022
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Thats over 10 years of @AKUGlobal alumni in that picture! thank you for bringing us together and look forward to growing the group in years to come. #ASH22.
Had the wonderful opportunity to get a quick hello in with fellow @AKUGlobal alums @ManniMD1 @BilalAbidMD @Irumkhan_hem & @DrAyeshaButt - So inspired by these wonderful people!! 🇵🇰🇺🇸. Hoping to continue this great tradition of #AKUatASH for years to come! #ASH22
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Abst 0933 Multiomic single cell analysis of ven-gilt aml treated pts suggests all RAS mut were present at v low levels at diagnosis in cells containing FLT3 mut. So expansion shaped by therapy AND inc expression of monocytic surf markers w treatment #ASH22 #leusm @vekennedy.
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RT @TamaraDunnMD: Just finished facilitating the #ASH22 #healthequity studio with @Irumkhan_hem on recognizing and addressing #ImplicitBias….
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