Igor Tascon
@IgorTascon
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Structural biologist @BiofisikaScienc @ikerbasque
Joined September 2021
Thrilled to see our work on high-resolution #cryoem using a common LaB6 120-keV TEM and sub–200-keV direct electron detector, now online @ScienceAdvances. https://t.co/WGbo5j3xWO . A collaboration with @GatanMicroscopy, @GeorgRamm, and @CryoEM_Monash.
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Our paper on the reaction cycle of the human dicarboxylate transporter NaDC3 finally came out in @nsmb .
Substrate translocation and inhibition in human dicarboxylate transporter NaDC3 | Nat Struct Mol Biol https://t.co/MUNJ2HBi6G
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📢 @JGarciaNafria receives €2 million from the ERC program to find new mechanisms to control #inflammation . #ReSolVer will study the end phase of #inflammation , and will provide strategies for the development of new anti-inflammatory drugs. Congrats! @UccUnizar
#ReSolVer
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Find our fresh peer-reviewed report on “Molecular Architecture of Synaptic Vesicles” here: https://t.co/E7hGfT7sTk We analyzed synaptic vesicles in neurons and in isolation to describe molecules on their surface. 🧠💥🔬
pnas.org
Synaptic vesicles (SVs) store and transport neurotransmitters to the presynaptic active zone for release by exocytosis. After release, SV proteins ...
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Great opportunity to work with an amazing PI, apply!!
📢 Postdoctoral Position: Join Instituto Biofisika (Bilbao, Spain) to develop antibody & lipid nanodisc therapies for cancer. 🧬Focus: Protein engineering, oncology, drug delivery 📅Apply by: Jan 6, 2025 🔗More info: https://t.co/1mxejX6pz5
#PostdocPosition #CancerResearch
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5 days left to apply for the postdoc and research scientist positions in cryo-EM & protein design in our lab! 🔬🦠🧬 They're fully funded for 4 years. Salary: 42,800 euros gross per year. See details below:
We're currently looking for new members to join our lab! If you're excited about this research, feel free to reach out! We already have two open, fully funded positions: 🔬- Postdoc: https://t.co/cKH9W9uNOG 🧪- Senior Scientist:
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Congrats Rafa! 💪🏾💪🏾
Many thanks to @FundlaCaixa @CaixaResearch for the incredible support to work on this important problem together with Borja Ibarra @3M_lab and Cristina Ugalde Postdoc positions will be opening soon! Exciting times ahead!
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We're currently looking for new members to join our lab! If you're excited about this research, feel free to reach out! We already have two open, fully funded positions: 🔬- Postdoc: https://t.co/cKH9W9uNOG 🧪- Senior Scientist:
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It is finally out! Have a look on how bacterial ESCRT-III protein Vipp1 progresses from 2D to 3D to carry out membrane remodeling. Honored to have contributed here!
Now out in NSMB for those who missed our biorxiv back in 2023..
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🔴@IgorTascon and Iban Ubarretxena @Ubarretxena are co-corresponding authors of a paper pubished in @ScienceAdvances "Structural basis for regulation of a CBASS-CRISPR-Cas defense island by a transmembrane anti-σ factor and its ECF σ partner" Congrats!
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A reminder that our new lab at @MolBiolAU has a fully funded postdoc position available. Our group integrates biochemistry, cryoEM, and single-molecule imaging to explore the mechanisms of DNA repair complexes. 🧬🔬 https://t.co/JmQsioLLF5 Please share with your colleagues!
sites.google.com
We use biochemistry, structural biology and single-molecule imaging to understand how DNA damage is recognised, signalled and repaired. We are based in the Department of Molecular Biology and...
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I'am thrilled to share our latest paper, revealing how specific lipids play a critical role in the HIV neutralization process:
pubs.acs.org
Establishment of interactions with the envelope lipids is a cardinal feature of broadly neutralizing antibodies (bnAbs) that recognize the Env membrane-proximal external region (MPER) of HIV. The...
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From our neighbor next door!
Automated fiducial-based alignment of cryo-electron tomography tilt series in Dynamo
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First data from my PhD out now in preprint! Turns out that the orphan SLC45A4 is a polyamine transporter involved in pain signalling, that contains a novel autoinhibitory plug domain https://t.co/wx48T322mz
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The γTuRC saga goes on! This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator. Another tour de force led by @sernarina and Fabian Zimmermann and a fun collab with @LudersLab @IRBBarcelona. https://t.co/0fEKmBGzQd
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Cryo-EM is a bit of an imaging miracle. We collect 2D images with stupid amounts of noise. We don’t know what we’re looking at, or from which way. Yet some how we can churn it over and get to see (actually see) how life works on molecular scales in 3D. How?
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Man-made hinges date back to 1600 BC. ⭐️postdoc Benedikt Kuhn et al. now show that elevator-like #solutecarriers had them long before 🤩 to control conformational space + function! Great collab w Julian Langer lab and @seegerlab. Out in @NatureComms
https://t.co/EoNqdqCB6l
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Delighted to get this out!we describe bitopic binding mode to the dopamine 3 receptor, including a reorganization of TM1 that generates a unique site that could be exploited to develop selective molecules. Tremendous effort from @sandrarrour @angela31398
https://t.co/3CsQKXSFpb
nature.com
Nature Communications - Developing subtype selective drugs for GPCRs is a major focus of research. Here, Arroyo-Urea et al. point to an unexploited selectivity site in aminergic receptors, as seen...
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Cool! Congrats Misha and team!
We have a new paper for you: “Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel”. Here we found that the prototypical pentameric ligand gated ion channel can form stable tetramers and characterized it with cryo-EM/ET and molecular simulations.
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