Eric Geertsma
@inverted_repeat
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Membrane biochemist @mpicbg with a strong affection for solute carriers and their transport mechanisms. Dreams big about nanobodies. Will one day own a herd.
Joined April 2018
Man-made hinges date back to 1600 BC. ⭐️postdoc Benedikt Kuhn et al. now show that elevator-like #solutecarriers had them long before 🤩 to control conformational space + function! .Great collab w Julian Langer lab and @seegerlab. Out in @NatureComms.
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Positive news for negative ions! 👉@HendrikSikkema received a #MSCA postdoctoral fellowship!!! 🎉🥳.QuantiCl will study anion transport in organ development & function @mpicbg . Stay tuned!😊
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RT @imprs_mpicbg: #Biophysics #Lifesciences #Chemistry Looking for interdisciplinary backgrounds for our diverse projects, from @jvveenvlie….
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It has a name! .Connectionless beta-helix or beta-helix nanotube!.First proposed by. 🥁Max Perutz in 2002. Described in more detail here: Credits to @Poslab_RND
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Somewhat confused. anyone ever stumbled over this 👇 structural element? What is it called? An alpha-helical beta-strand? 🙄.Or is this AI-fantasy?💥🌈🦄.Found in #alphafold's Period:
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Wow! 👇Well-earned!😀🍾. Bert Poolman appointed Knight in the Order of the Dutch Lion
rug.nl
Bert Poolman (Avereest, 1959) is op 26 april benoemd tot Ridder in de Orde van de Nederlandse Leeuw. Hij is hoogleraar Biochemie en programmadirecteur van...
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From mega to macro to pro-macro. and my guess is this is not the end of it yet. 😎.How a small #nanobody turned big and rigid (and on the fly contributed to the structure of the LptDE outer membrane protein complex!!!)👇.
leadXpro is happy to report the structure of LptDE - solved by cryo-EM at high resolution - which provides structural basis for the discovery of novel antibiotics targeting lipopolysaccharide (LPS) transport on the bacteria outer membrane.
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RT @mikhailshapiro: 24 yrs ago, Roger Tsien et al introduced the first fluorescent biosensors based on #GFP. Today, we introduce the first….
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Mixed f̶e̶e̶l̶i̶n̶g̶s̶ observations over mixed d̶r̶i̶n̶k̶s̶ conformations. Check out Katharina's review on cooperativity in elevator transporters!! .🌟With a special guest role for bilayer deformations🌟.
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First-ever description of cross-species #genderequity?? 🤔.Bit too bloody for my taste but nevertheless: wow! .This week in @zeitonline.
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#FOR5046: SLC26 transporters across scales. From molecular structure and cell biology to (patho)physiology. More info at (in German).
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Delighted to announce our new Research Unit on Solute Carrier family 26 got funded by @dfg_public! 😊.Headed by Dominik Oliver (@Uni_MR) & me (@mpicbg), with a great team from @fz_juelich, @unirostock, @HHU_de, @ChariteBerlin, #medizinischehochschulehannover & @goetheuni.
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RT @seegerlab: 📢Our rapid response to the COVID-19 pandemic on @biorxivpreprint .„Synthetic nanobodies targeting the SARS-CoV-2 receptor-bi….
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RT @giuliosf: Setting the record straight on the resignation of the ERC president
erc.europa.eu
The ERC's Scientific Council notes with regret the statement made by Mauro Ferrari concerning his resignation on 7 April. We here present the facts of the situation.
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From "Swiss made" to homemade!.Your own synthetic nanobodies in 196 steps 😃.Out now: Great collaboration with @seegerlab and @inwardopen!.
nature.com
Nature Protocols - This protocol describes in vitro procedures for generation of synthetic single-domain antibodies called ‘sybodies’. Sybodies can be engineered to target specific...
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First day of home office @mpicbg !.Hello there #Dresden !.Interesting timing amidst a #pandemic and on #AprilFoolsDay but this is happening #ForReal. Excited!
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