Sigurbjörn Markússon
@BjossiM
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Icelander living in Oxford - Structural biology PhD student, University of Oxford
Oxford, UK
Joined April 2011
First data from my PhD out now in preprint! Turns out that the orphan SLC45A4 is a polyamine transporter involved in pain signalling, that contains a novel autoinhibitory plug domain.
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RT @MemProtPDB: Structural basis for antibiotic transport and inhibition in PepT2 | Nat Commun. .
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RT @MemProtPDB: Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter | bioRxiv. https….
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A great team effort in the @inwardopen.lab, in fantastic collaboration with the Bennet lab @MiddletonSJ_ and others, including @LeaLabTweets @justindeme85.
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RT @inwardopen: Latest preprint from the group has landed - Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transpor….
biorxiv.org
Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy[1][1]. They are implicated in multiple neurological disorders including stroke,...
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RT @inwardopen: Congratulations to our new Dr Löbel! @BiochemOxford @KavliOxford thanks to Paul @Elliott_Lab_Ox and David Drew https://t.co….
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RT @larissadi2: Excited to share our most recent work on the giant ubiquitin ligase #BIRC6 out now in @ScienceMagazine .
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RT @BiochemistryACS: Alkaline phosphatases (APs) use various methods to adapt environmentally. Hjörleifsson, @BjossiM and colleagues @uni_i….
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And last but not least, a huge shoutout to Tony the Pony (pictured below, @petrikursula @inari_kursula), who supplied wonderful pony hairs that allowed for streak seeding some of the beautiful (atomic resolution) crystal we used in this study!
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Thanks to the twitterless Jens, @basgeirsson @PetriKursulaLab and @Neurotarget_UiB for a great collaboration.
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Ever wondered how enzymes adapt to cold and saline environments? Then our new paper on the structural basis for chloride activation/stabilization of a marine bacterial phosphatase might be of interest! Out now in @BiochemistryACS
pubs.acs.org
Enzyme stability and function can be affected by various environmental factors, such as temperature, pH, and ionic strength. Enzymes that are located outside the relatively unchanging environment of...
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RT @inwardopen: Great to see Mark's paper out - The structural basis for cystine transport via cystinosin! Further….
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Our new paper on Arc is out now in @PLOSONE! We used Nb-aided crystallography, SAXS and simulations to look at the dynamic CTD, and found a surprising inhibitory Nb. Thanks to @PetriKursulaLab @yesthisisarne @Neurotarget_UiB and everyone else involved!
journals.plos.org
Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals....
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RT @RanieNro: Mikið djöfull sem það verður gaman að fá @KRHandbolti í #Olísdeildin á næsta vetri. Til hamingju.
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