Kallol Gupta
@GuptaLab1
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We make tools that render a quantitative view of #membraneproteins and #lipids at the #cellmembrane @YaleCellBio. #Massspectrometers are our favorite toys
Yale School of Medicine
Joined October 2021
Excited to see our work on the cover of @naturemethods We present a #nativemassspectrometry platform to detect #membraneprotein #lipid complexes directly from tunable #membranes Special thanks to Hannah Wang. One for #TeamMassSpec.@YaleCellBio.@YaleWestCampus.@YaleMed.@Yale.
Our June issue is live! 🎉. On the cover, from @GuptaLab1 and artist Hanna Wang, a native mass spectrometry platform captures membrane protein–lipid organization directly from tunable lipid membranes. Paper here:
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If @ #BPS2025 , check out the talk by @CBcellbiologist today in the "Protein Lipid Interactions: Structure and Dynamics" Session @ 12PM. She will present our recently developed platform to capture membrane proteins in their native nanodomains & some exciting applications of it.
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Work was led by @CBcellbiologist and @SnehasishG87, with critical contributions from other lab members & labs of  @moitrayee_lab @Yanshen73854711 & Rothmanlab.
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All Data publicly available via & Searchable through Uniprot names. We hope this will enable #membraneprotein researchers to extract & study their favorite proteins, at endogenous expression levels, directly from native environment.
polymerscreen.streamlit.app
This app was built in Streamlit! Check it out and visit https://streamlit.io for more awesome community apps. 🎈
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Very excited to see this work coming out. Combining membrane-active polymers with #proteomics we present the most optimal conditions to extract>2000 individual endogenous membrane proteins into nativenanodiscs.@YaleCellBio .@YaleWestCampus .@YaleMed.
Work from @GuptaLab1 presents a high-throughput platform for extracting membrane proteins into native nanodiscs that retains the local membrane context, accompanied by a database of optimal extraction conditions for 2000+ mammalian membrane proteins.
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If you are @ProteinSociety annual meeting, check out the talks and posters by @CBcellbiologist and @Rachelmcalli on our new tools to understand how the native #membrane regulates #membraneproteins and its application on a B cell protein (with @moitrayee_lab)
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If you are @ #BPS #Membrane #Biophysics meeting @Tahoe, check out Caroline's talk today. She describes our new & exciting platform to capture >2000 unique #membraneproteins in their native nanodomains with high efficiency and nanoscale spatial resolution
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If @ #ASMS2024, check out all our exciting works describing new technologies to study molecular organization of #membraneproteins and #lipids at the #membrane
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RT @moitrayee_lab: Meet us @moitrayee_lab at #BPS2024 with posters from @GTWalker7 and @Rachelmcalli and my talk at the #FutureofBiophysics….
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If @ #BPS2024, check out all our exciting works describing new technologies to study molecular organization of #membraneproteins and #lipids directly from the #membrane and its applications in understanding various membrane-associated signaling events
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very happy to play our part in the fantastic work led by @moitrayee_lab, in collaboration with the @MuzumdarLab. Work spearheaded by two of our champion grad students @GTWalker7 and @CBcellbiologist.
Here is a tweetorial summarizing findings from our recent paper from @YalePharm @YaleMed in @NatureNano by @GTWalker7 and @CBcellbiologist. Dream team @shalgene @Xiangyu_GigiG @MuzumdarLab @GuptaLab1! Also see the N&Vs at by @KrishnanYamuna!.
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A very exciting application of #ESIBD.
Out today in @ScienceMagazine: Seeing glycans attached to proteins and lipids - at the *single molecule level*! 🎉🎉🎉 . #ScienceResearch #glycotime #teammassspec. My 1st #tweetorial🧵(1/n) 👇👇👇
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What a cool tool!!.
Our article on in vivo force sensors appeared in Science Advances. Thank Yuan Ren, Julien Berro @BerroLab, and Jie Yang! Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors | Science Advances
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Extremely honored to be recognized as an Emerging Investigator by the American Society for Mass Spectrometry @asmsnews. Credit goes to my amazing lab members for their hard work. Special thanks to my past mentors & present colleagues at @YaleWestCampus @YaleCellBio @YaleMed.
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Turns out Gas phase is not that bad! Very exciting.
We used #nativeMS electrospray ion beam deposition (ESIBD) to make samples for #cryoEM: mass-filtered, soft-landing deposition, cold substrate, in-situ ice growth, clean+cold transfer. we find. @ESIBDLab with many colleagues.@OxfordChemistry @KavliOxford .#structuralbiology
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RT @RuotoloLab: See our lab's latest JASMS publication! In this work, our lab deploys this quantitative CIU methodology to measure isomass….
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RT @TJ_MeliaLab: Congrats Justin! Really nice work showing ATG2 function on monolayer-wrapped LDs and careful characterization of a transpo….
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If you are @ProteinSociety meeting #PS37, please check out the exciting work of @anipan84 (Poster20AB), showing how we can directly determine macromolecular organization of #membraneproteins and #lipds directly from synthetic and cellular membranes using #nativemassspectrometry.
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If you are @ProteinSociety meeting #PS37, please check out the exciting work of our grad student @Rachelmcalli (Poster114AB), showing how lipid vesicle #nativemassspectrometry can decipher membrane recruitment mechanism of a B-cell kinase.
Rachel McAlister @Rachelmcalli is representing us at the @ProteinSociety meeting #PS37. Stop by her poster 114AB to check out a native MS based general experimental platform to identify and quantify lipid binding in membrane association domains (collaboration with @GuptaLab1).
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RT @Yanshen73854711: Check out our new study published at @NatureComms in which we investigated the Akt1 #signaling and dynamics using an o….
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