Kelvin Anggara
@vixklen
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ERC Group Leader @mpifkf on Single Molecule Chemistry | PhD @chemuoft | @AvHStiftung postdoc @mpifkf | #LINO13 Alum | 🇮🇩 in 🇩🇪
Stuttgart, Germany
Joined July 2018
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Out today in
@ScienceMagazine
: Seeing glycans attached to proteins and lipids - at the *single molecule level*! 🎉🎉🎉
#ScienceResearch
#glycotime
#teammassspec
My 1st
#tweetorial
🧵(1/n) 👇👇👇
37
408
2K
(10/n) We're excited to look into more exciting stuff! 🔥🔥🔥
JOIN US - if you're looking for
#PhDposition
or
#postdocposition
!
#chempostdoc
#chemphd
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🚨JOB ALERT🚨
Join me at
@mpifkf
to *see* single glycan molecules & crack some 'sugar code'!
1 PhD & 1 Postdoc openings by
@ERC_Research
#chempostdoc
#chemphd
#chemtwitter
#teammassspec
#glycotime
More:
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(4/n) What can we see with STM?
Let's start with simple
#glycopeptide
.
We can:
1. Distinguish glycans from peptides! 😎
2. And even distinguish Glucose from Galactose (they differ only by 1 stereoconfiguration i.e. -OH at C4) 🤯
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Pretty pictures of skyrmion in 2D magnets! Was blown away by this when Lukas first presented it at the group meetings. Congrats!!
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(7/n) Moving on to glycoprotein! What could these images tell us? We can distinguish glycoforms at single molecule level! 🥳
1st. We can tell where the glycan is connected at along the protein backbone. 😎
2nd. And... tell the glycan structure on that site! 😋
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Excited to be a part of
#2023HFSPAwardee
! 🎉🎉🎉 Together with Prof. Rebecca L. Miller (
@cphglyco
), we will study structures of sulfated polysaccharides (aka
#GAGs
) one-at-a-time! Thank you
#HFSP
for the
#HFSPResearchGrants
! 🍻
It is time for single molecule
#glycotime
! 🔥🔥🔥
It's official! The 2023
#HFSP
New Awardees are here! Congratulations to the 34 winning teams of
#HFSPResearchGrants
and the 52 researchers awarded
#HFSPFellowships
! 🥳Are you a
#2023HFSPAwardee
? 🏆Tell us! +info:
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(9/n) I'd like to thank
@mpifkf
,
@ESIBDLab
,
@cphglyco
,
@uni_tue
for the great adventures. 🍻🍻
Also,
@ERC_Research
,
@AvHStiftung
,
@bwstiftung
,
@EMBO
,
@novonordiskfond
,
@GrundforskFond
, Mizutani Foundation,
@lundbeckfonden
,
@Carlsbergfondet
for funding! 🍻🍻
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Great to see Johannes' work finally out! 🎉🎉🎉 Seeing the glycosidic bonds in carbohydrates was an unforgettable
#glycotime
experience! 🍻 Great collab with
@DelbiancoM
@peterseeberger
@DynamicsCondMat
@MirhosseiniHo
Visualizing Chiral Interactions in Carbohydrates Adsorbed on Au(111) by High-Resolution STM Imaging (Klaus Kern and co-workers)
@mpifkf
@EPFL_en
#OpenAccess
thanks to
#ProjektDEAL
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(2/n) Glycan-decorated proteins and lipids (a.k.a. glycoconjugates) are EVERYWHERE in cells! - playing many important roles in health and diseases!❤️❤️🩹()
But, figuring out their molecular structures by ensemble-averaged techniques are challenging! 🔥🔥🔥
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Nobody:
Me (during 2020 lockdown): Hey, what happens to
#proteins
when we throw them onto a one-atom-thick membrane?
Ans: Molecule-on-trampoline!
()
#ASAP
at
@ACSCentSci
by
@ESIBDlab
and
@mpifkf
#softlanding
#chemtwitter
#teammassspec
#analyticalchem
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Excited to share my work with Holography team
@mpifkf
:
#DFT
on a 12 kDa protein!🔥🔥🔥(cuz I am too bored at home during 2020 lockdown 😋)
Also I made a Cover Art inspired from
@tsutomu_nihei
Shidonia no Kishi by
#Blender3d
+
#photoshop
@ACS4Authors
#MyACSCover
#sciart
#scicomm
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Hear hear! My PhD supervisor best advice: "Only be at places that care about your success."
"Don’t let anyone talk you into believing you’re worth less than what you know you’re truly worth."
#ScienceMagArchives
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@MannaLiberato
During late undergrad/early PhD, I struggle a lot with the 'mathematical' language of physicists. I strongly recommend to anyone having this problem to check out Roald Hoffmann beautiful attempt to bridge physics and chemistry:
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This is such a beautiful work! 🍻
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Very cool work by Soon Jung & team on imaging strained graphene!🙂 Very interesting to see materials at their non-equilibrium states.
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Very excited to be part of
#ERCStG
@ERC_Research
!
I will be leading a group
@mpifkf
to image glycoconjugates at single molecule level - in close collaboration with
@cphglyco
and
@DelbiancoM
(also an ERC grantee - congrats!). A win for
#glycotime
!
More at
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@CarolynBertozzi
Thank you for the shoutout, Dr. Bertozzi! We are excited to learn more about the wonderful glycoworld one-molecule-at-a-time! 😊
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Thanks so much for the highlight!
@DelbiancoM
@Cermav_UPR5301
@nchembio
🍻
We are excited to learn more about the glycoworld ... one molecule at a time!
#glycotime
Check out our News & Views about the beautiful work by
@vixklen
and coworkers published in
@ScienceMagazine
@MpiciPotsdam
@Cermav_UPR5301
@nchembio
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Thank you
@pagelgroup
for hosting me last October! I enjoyed hearing the super cool science happening at
#SupraFAB
@fubcp
! 🍻
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Lots of new exciting science awaits!
We are hiring: If you are interested in cryoEM and looking for a twist (=gas phase deposition of native proteins for sample preparation) then this might be the postdoc for you. Be in touch ... Advert online:
#postdoc
#cryoEM
#nativeESI
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@Ella_Maru
Landing proteins! I used blender and then photoshop to achieve non-photorealistic anime-look (
@tsutomu_nihei
style - to be exact) 😊
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I am a huge fan of Prof Clemmer's papers! 👍
Congrats to Professor David E. Clemmer from Indiana University Bloomington for recently receiving the ACS 2023 Frank H. Field and Joe L. Franklin Award for Outstanding Achievement in Mass Spectrometry!
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@hirenj
@chrashwood
@MerryLabNotts
@AlanGrodzinsky
@AnnaPlaas
Hi Chris, Hi Hiren, AFM resolution in space & time has seen great advances. I love the work by
@George_R_Heath
and
@ScheuringLab
().
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Let there be light (at low temperatures!) ☀️
Read about
@aparajitaph
work on shallow NV probes in UHV & cryogenic temperature.
📸Pictured here is water molecules physisorbed onto a diamond surface, allowing favorable band bending, and the revival of optical & spin properties of shallow NV-probes.
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@MerryLabNotts
@hirenj
@chrashwood
@AlanGrodzinsky
@AnnaPlaas
Dear Dr. Merry, the Q on how far from 'native' is definitely an important question - more work is needed!
@ESIBDLab
has investigated this by imaging (with cryoEM) soft-landed proteins from electrospray () - and the structure is remarkably similar!
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@mhg_group
@fullCIalchemist
Super cool! Who would've thought that molecules are the most polarizable when their bonds are stretched that much!
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@hirenj
@chrashwood
@MerryLabNotts
@AlanGrodzinsky
@AnnaPlaas
@George_R_Heath
@ScheuringLab
Concerning throughput, I get 1 data point per hour - and yes, Chris, we need to image hundreds of molecules to get a representative sampling of the population. However, this low throughput originates from many manual steps in finding molecules, sharpening the tip, and analysis.
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@hirenj
@chrashwood
@MerryLabNotts
@AlanGrodzinsky
@AnnaPlaas
@George_R_Heath
@ScheuringLab
We are still at infancy when it comes to throughput (because we don't have nice softwares - like the ones cyroEM community have - to automate all these manual operations yet). It's one of my focus to get the throughput up! 🙂
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Looking forward to hear many great things again in 2 years time 🍻
Just back from MS+M_2023 hosted by
@Coon_Labs
,
@RuotoloLab
and
@ESIBDLab
, with exciting and groundbreaking developments in MS, EM, AFM&STM presented. Look forward to see this thriving community back at MS+M_2025
@vixklen
@uetrechtlab
@NativeMassSpec
@nativemsoxford1
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Check out the paper here:
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@DanielRosenblat
@ScienceMagazine
Thanks Daniel! For now, simply topography and DFT - but soon we are looking into getting some spectroscopic mapping too. It's hard - but we think it is going to be worth the pain! 😋
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Is this it?! Is this it!??
Extraordinary news in a preprint on condensed matter physics: Lee, et al. claim to have made the first material that is a superconductor at ambient temperature and pressure.
If true, will change the world.
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@mpifkf
@ERC_Research
@cphglyco
@DelbiancoM
Thanks so much! 😁 Looking forward to work together in future!
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Beautiful! :)
2D topological superconductivity is taking shape, built atom by atom as Shiba lattice. Take a look at our recent work , led by Martina Soldini and Felix Küster in a wonderful collaboration between
@UZHMat
@UZHPhysics
and the
@PaoloSessi
group
@mpi_msp
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@hirenj
@chrashwood
@MerryLabNotts
@AlanGrodzinsky
@AnnaPlaas
@George_R_Heath
@ScheuringLab
Yes,
@hirenj
, it is a difficult problem - but a soluble one! 👍
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Purple carrots = future of chemistry! 🎉🎉🎉
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@DanielRosenblat
@ESIBDLab
@scienta_omicron
lol. First, I'd like to try frying an egg on surface ... 🍳🍳🍳
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Super noice! Coupling Xray into tunnel junction 🍻🍻🍻 Congrats to the authors! 🎉🎉🎉
Excited to share our latest publication! 🎉🎆😁Have you ever wondered what the X-ray signature is of just one atom?
#OhioUniversity
@argonne
@advancedphoton
#RareEarth
#STM
#XTIP
Thanks to all collaborators😉
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@EmmaJCurran
The title is intriguing! Now I am curious to read it. By any chance, is there any online softcopy of it (maybe a thesis repository)? 😊
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This is a very impressive paper from
@mpifkf
!
They report the synthesis of *single crystals* of Pb10−xCux(PO4)6O with x ~ 1 ("LK-99") using TSFZ without any sulfur (or Cu2S) impurities.
TL;dr the crystals are transparent, diamagnetic insulators.
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Insightful!
In the context of recent discussions, sparked by a
@Nature
article, about why science is becoming less disruptive with time, I think these prophecies by Leo Szilard in 1948 are very relevant:
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The legendary Murray-Bawendi JACS paper!
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2023
#NobelPrize
in Chemistry to Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov “for the discovery and synthesis of quantum dots.”
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Super noice! (Love the analysis too!) 🍻
Our latest work in
@NatureComms
:
Turns out SARS spikes have "gadget" arms, which use glycans to strengthen their grip. AFM movie: RBDs dancing around.
Thanks Hinterdorfer lab
@HummerLab
@AhmadRezaMehdi1
!
@MPIbp
@jkulinz
@MCB_UJ
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Excited to visit Madison for the first time! A big thank you to
@Coon_Labs
and team for organizing this! Looking forward to meet colleagues in
#analyticalchem
technique development!
Let's analyze some biomolecules!
#chemtwitter
#teammassspec
#glycotime
#compchem
#msm23
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@peterseeberger
@ERC_Research
@DelbiancoM
@BioMolSys
@MpiciPotsdam
Thanks so much
@peterseeberger
and
@DelbiancoM
! Very excited to visualize more glycans and understand their chemistry!
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Ooops. Sorry I mislabeled some glycosidic bonds... (some beta4 should be alpha4). Here's the correct one!
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Thank you all for the applications! We have identified prospective candidates and we now would like to close the call! 😊
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@pdeioann
@ScienceMagazine
Yes! We unfold them so that we can see the glycans better. We are working towards getting some folding information too! 😋
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@IsabelleCompag1
This is such a beautiful idea! I'd love to have a set in the lab!
(P.S. Happy to pay for the production/labor/delivery costs etc.)
(P.S.S.
#glycofun
is such an amazing hashtag!)
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@D_B_McConnell
Cool graph! 🍻 Wondering if these can be used to predict solubility in water - or ethanol?
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@thaher
@ScienceMagazine
Of course! More things to take a look at! Thanks for the suggestions 😊
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@mglerner
@ScienceMagazine
Hi Michael, yes, these are all STM images. You are correct that STM heights originate from density-of-states (i.e. ~conductivity) and physical heights. This is why it is important to do STM simulations to interpret the image. 😊
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@ccstorytime
@ScienceMagazine
Thank you for the kind words! We are excited to see more of the glycoworld! 😊
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Exciting!! 🎉
(1/2) Good news! Canada will be entering into formal negotiations with the European Union for closer collaboration in
#research
and
#innovation
under
@HorizonEU
.
@EUScienceInnov
@vestager
@GabrielMariya
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@wangjia92981756
One could measure the heat released when molecules stick onto surfaces!
Charlie Campbell comes to my mind (see & )
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@Jiaxing_Tan_
@raflynn5
@ScienceMagazine
Of course.
@Leo_Gross_IBM
has beautiful work on figuring out structures of aromatic molecules! (), (), (), and many more!
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@ChemicalBiology
@CarolynBertozzi
Thank you for the kind words, Dr. Kiessling! 😊 We are so excited to be able to contribute to this amazing field. 👍
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