Beatriz Beamud
@BeatrizBeamud
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🧪 Bacteria, Phages & Genomics 💻 Synthetic Biology Group @institutpasteur 👩🔬 PhD @GVAfisabio @i2sysbio
París, France
Joined October 2017
Thrilled to see this one out! It's been so much fun to go over so many great papers from the last years 🙏🏼
Going viral: The role of mobile genetic elements in bacterial immunity @BeatrizBeamud @FabBenz @dbikard review work revealing that most bacterial defense systems are carried by mobile elements, indicating complex evolutionary forces driving immunity https://t.co/iLMpbZpoa5
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Can we exploit past phage infection events (prophages) to decipher the specificity of phage receptor-binding proteins such as depolymerases?🔎 Happy to share our recent work at @NatureComms 🔽 https://t.co/JS1zr1XWo7
nature.com
Nature Communications - Here, the authors exploit the genetic information encoded in Klebsiella prophages to model the interplay between bacteria, prophages, and their depolymerases, using a...
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Massive effort lead by the amazing @FabBenz to discuss the present and future of CRISPR-based antimicrobials ⚡
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1/6 🚀 Delighted to see our review out online in Nature Reviews Bioengineering: CRISPR–Cas therapies targeting bacteria. Read:
nature.com
Nature Reviews Bioengineering - CRISPR–Cas tools can be designed to kill or modify specific bacteria. This Review explores the engineering of CRISPR–Cas tools and corresponding delivery...
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Gran Jornada en París @CdE_Paris sobre Resistencia a los Antibióticos con @MariadelMarTom @M_AresArroyo @JFDelgado_Blas @DoradoMoralesP @CarlitosRoca7 @BeatrizBeamud Gracias ❤️ @SIEF_SCEF @EmbEspFrancia @FundacionAreces
@SEIMC_ @SEMicrobiologia @AruUcm @unicomplutense @fpa
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For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmids from any bacterial species. We are thrilled to see this work now published in @NatureMicrobiol after thorough peer review! https://t.co/TpTxRy7jjd
nature.com
Nature Microbiology - Characterization of known plasmid oriT features facilitates identification of 21 oriT-containing sequence families which, alongside candidate sequence validation, expands our...
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📢 SIEF te invita a participar en nuestra Jornada de Divulgación Científica sobre #resistencia a los #antibióticos 💪💊, uno de los mayores retos para la salud global🌏, el próximo 23 de noviembre (#23N) en el @CdE_Paris‼️🧵👇
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Prophages represent past infection events. Can we leverage this data to predict phage specificity? A big shoutout to @ConchaEloko for leading this project! 👏👏
Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases
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Very happy to work on the interaction between MGEs with @M_AresArroyo🥳🥳 Thanks @institutpasteur for the opportunity 🙏
Interested in phages and plasmids? 🧐 We are too! Happy to share that @BeatrizBeamud and I are among the recipients of the Postdoc Seed Grants of @institutpasteur! Can’t wait to share the results of our joint project!
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1/ 🧵 Thrilled to share work of @EligoBio just published in @Nature ! We show proof of principle results of efficient base editing performed on E. coli directly in the mouse gut 🦠💡 #Microbiome #SyntheticBiology
https://t.co/efTztuluN9
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First cases of phage compassionate use in Spain with very interesting insights about phage-bacteria dynamics in vivo + immune system 👏
Latest @MedCellPress from #EnBiVirLab! We report the emergence of #NAb after nebulized #phagetherapy with the first spanish vials approved by @AEMPSGOB. Despite immune responses we achived positive clinical outcome! @i2sysbio
@UV_EG
@FEFQ_CFspain
@PRANgob
https://t.co/Xhhr5SlHP6
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¡Qué súper experiencia! Muchas gracias @SIEF_SCEF y @pintofscienceFR por hacerlo posible! Muy sorprendida con la vena artística de los asistentes ⬇️🫶
¡Qué alegría haber contado con tant@s de vosotr@s en el #pint24 de París! 😀 Y menudos ponentes‼️Javier Pizarro nos desveló los secretos de la #peste y su uso como arma biológica con 🎵, mientras que @BeatrizBeamud decidió aliarse con los #virus para luchar contra bacterias 👊🧫
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This amazing story is out!!! Massive congratulations 🥂🥂🥳
Do plasmids fight other plasmids? Finally, our paper on Type IV CRISPR-Cas is out in @cellhostmicrobe 💥 massive thanks to shared-first @SarahCamara94, @rafapinilla92 and all the other co-authors 🤗
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The antimicrobial potential of #CRISPRCas systems is promising, yet how to best design or implement CRISPR nucleases remains poorly understood. Researchers from #HIRI, @Helmholtz_HZI, @UofT, @TelAvivUni & @institutpasteur have addressed this knowledge gap:
helmholtz-hiri.de
HIRI researchers conducted the first systematic study of CRISPR-based antibiotics in Klebsiella pneumoniae
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From detecting 30% and 1% origins of plasmid transfer in Klebsiella and Acinetobacter to 80%!! This is great, congrats!! 🥳
New preprint alert! 🚨 Our latest work on plasmid mobility with @epcrocha & @NucciAmandine is now available. Identification of novel origins of transfer across bacterial plasmids. Read the full paper here: https://t.co/Ww8KuXyNZf Thread🧵below!
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A step closer to predict phage-bacteria interactions from genomes, congrats to the whole team for this massive work! 🎉
💻🧫New preprint: How accurately can we predict diverse phage bacteria-interactions from their genomes only ? We created a matrix of >38k phage-bacteria interactions to find out (=> AUROC 86%) & used our predictions to recommend tailored phage cocktails. https://t.co/0EFljCmV7c
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Absolutely stoked that my PhD work, supervised by @MonsieurRoti and @QuintanaMurci, is out @Nature! A story of adaptation to viral pressure across human populations and immune cell types. 🧵 (1/18) (TL;DR below).
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Already loving this initiative!! 💯💯
Hi phage biologists/enthusiasts! We are excited to share KlebPhaCol, a barrier-free, #opensource and expandable #Klebsiella #phage and strain collection for your research. #KlebPhaCol currently contains 52 phages and >24 strains to request, use and share! https://t.co/n4PPFmEWJK
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and really happy about where this journey has brought me #SynBioTeam! Can´t be in a better place for this new adventure that I am already enjoying! (PD: it's not that winter has already arrived in Paris but the Xmas lunch picture😅)
What a journey! 🎓Lots of emotions these past few days. Huge thanks to everyone who made this possible, especially my supervisors @fgonzalef @Rafa_Sanjuan_ @pilardomingoc for their support and invaluable guidance throughout the years 🙏🥳
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