Arpaia Lab
@arpaialab
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Mucosal Immunity | Cancer Immunology Department of Microbiology & Immunology @Columbia_MI Columbia University Irving Medical Center @ColumbiaMed
New York, New York
Joined June 2022
New paper in collab w/ @tdanino lab out today in @Nature! @andrewredenti, @JongwonIm8158 and team engineer probiotic E. coli as cancer vaccines to stimulate tumor neoantigen–specific immunity and kill solid tumors! @Columbia_MI @ColumbiaBME @columbiacancer
nature.com
Nature - Probiotic Escherichia coli Nissle 1917 is engineered as an antitumour vaccination platform optimized for enhanced production and cytosolic delivery of neoepitope-containing peptide arrays...
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The Arpaia Lab is currently recruiting for a Staff Associate I position 🧑🔬. Please share the following job description and application link with anyone you believe would be interested. Thank you!
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Excited to share a preprint of our latest study in collaboration w/ @tdanino's lab – synthetically engineered E. coli expressing CXCL13 synergizes with PD-1 blockade to amplify antitumor antibody responses and inhibit bladder cancer growth. @Columbia_MI
biorxiv.org
The intratumoral microbiome has recently emerged as a new hallmark of cancer, with implications for response or resistance to therapy. While bacteria can either promote or inhibit cancer growth,...
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Congrats @li_fangda and team! Another great collab w/ @tdanino's lab out today in @SciImmunology! Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms. @Columbia_MI @ColumbiaCMBS @columbiacancer
science.org
Bacteria engineered for intratumoral delivery of IFN-γ synergize with PD-1 blockade to overcome tumor-intrinsic immune resistance.
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RT @tdanino: New paper in collaboration w/@arpaialab out in Nature today! @andrewredenti, @JongwonIm8158 and team engineer E. coli Nissle p….
nature.com
Nature - Probiotic Escherichia coli Nissle 1917 is engineered as an antitumour vaccination platform optimized for enhanced production and cytosolic delivery of neoepitope-containing peptide arrays...
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RT @JExpMed: In this review, Loffredo, Savage, Ringham, & Arpaia @arpaialab @Columbia_MI examine interactions between Treg cells and tissue….
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Congrats 🥳 @Thomas_M_Savage and team on a study published today in Immunity demonstrating Treg-derived amphiregulin promotes NASH-induced liver fibrosis and glucose intolerance! 🧑🔬🍔🍟 @ColumbiaCMBS @Columbia_MI @cudldrc @MD_PHD_CUMC_VPS
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Excited to share our new preprint! We program probiotic bacteria to create a next generation anti-tumor vaccine that stimulates tumor neoantigen-specific immunity to control and eradicate solid tumors @ColumbiaCMBS @ColumbiaBME.
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RT @Columbia_MI: Check out this beautiful new study on the mechanism of DNA double-strand break resection initiation from the lab of @Colum….
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RT @columbiacancer: This #InternationalWomensDay, the HICCC celebrates all of our doctors, patients, researchers, and staff, who have worke….
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Excited to share our work published today in @ScienceAdvances!. @Thomas_M_Savage with @arpaialab and @tdanino lab members engineer bacteria to intratumorally release chemokines that recruit T cells and DCs into tumors, activating anti-cancer immunity.
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Excited to see our work featured on the March cover of @JExpMed!. Kaiser and @arpaialab team (@Columbia_MI) show Treg cell–derived amphiregulin is sensed by EGFR+Collagen-14+ lung mesenchymal cells in #influenza infection, promoting alveolar regeneration.
Our March cover shows a lung section of a mouse infected with influenza virus (red) with Tregs (green) and stained for secreted extracellular matrix proteoglycan Agrin (white). From Kaiser et al @arpaialab (. Read JEM’s March Issue:
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Excited to share our work from @LucilleRankin and @arpaialab team in @Columbia_MI! In brief, dietary tryptophan deficiency promotes expansion of intestinal RORγ+ Tregs in a microbiota dependent manner.
Dietary tryptophan deficiency promotes gut RORγt+ Treg cells at the expense of Gata3+ Treg cells and alters commensal microbiota metabolism
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RT @JExpMed: Our March cover shows a lung section of a mouse infected with influenza virus (red) with Tregs (green) and stained for secrete….
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RT @LucilleRankin: Excited to share our work from my time at @Columbia_MI. In brief, dietary Tryptophan depletion rather specifically promo….
cell.com
Rankin et al. show that dietary tryptophan deficiency reshapes the microbiota and alters intestinal gene expression profiles, resulting in a microbiota-dependent expansion of gut RORγt+ Tregs. These...
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RT @Columbia_MI: Check out this exciting work from @Columbia_MI student Kate Kaiser in @arpaialab, recently published in @JExpMed!.
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New publication from our lab out in @JExpMed!. Kaiser and team show that, during #influenza virus infection, Treg cell–derived amphiregulin is sensed by EGFR+Collagen-14+ lung mesenchymal cells, promoting alveolar regeneration.
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RT @JExpMed: Kaiser, Arpaia et al. @arpaialab @Columbia_MI show that, during #influenza virus infection, Treg cell–derived amphiregulin is….
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