escrivani_douglas
@EscrivaniD
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Postdoctoral Research Assistant | David Horn’s group | Working with antigenic variation in trypanosomes.🧬🔬🇧🇷🏴 @WCAIRDundee @UoDLifeSciences
Dundee, Scotland
Joined December 2018
Great to see this out! Big shout out to @EscrivaniD and @SebHutch_tryps & Horn Lab @WCAIRDundee @dundeeuni non-coding role for trypanosome VSG transcripts in allelic exclusion | Nucleic Acids Research | Oxford Academics
academic.oup.com
Abstract. Bloodstream-form African trypanosomes display antigenic variation. This requires mono-telomeric but switchable expression of a Variant Surface Gl
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Thrilled to share our latest work in Nucleic Acids Research! 🎉 We demonstrate that VSG transcripts in trypanosomes play a non-coding role in controlling allelic exclusion, revealing a new layer of RNA regulation. 🔗 https://t.co/Faja7fkXw5
#Trypanosomes #RNA #GeneRegulation
academic.oup.com
Abstract. Bloodstream-form African trypanosomes display antigenic variation. This requires mono-telomeric but switchable expression of a Variant Surface Gl
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Interested in gene expression control in trypansomes? See a new paper from the Horn group that describes cis-regulatory UTR sequence ‘code’ in T. brucei for the fist time, shedidng some light on how expression is regulated in an organism with constitutive trasncription.
Read the latest paper from @UoDLifeSciences @WCAIRDundee Anna Trenaman, Michele Tinti, Richard Wall & David Horn in @NatureComms
https://t.co/QSzGULJeIn
@BSParasitology@AmSocParasit @wiparasitology #trypanosomes
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#OpenAccess Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes https://t.co/6sSPlFZds4
@UoDLifeSciences
nature.com
Nature Communications - Cells that transcribe almost ‘everything everywhere all at once’ rely upon alternative expression controls. Here the authors employ massive parallel reporter...
Read the latest paper from @UoDLifeSciences @WCAIRDundee Anna Trenaman, Michele Tinti, Richard Wall & David Horn in @NatureComms
https://t.co/QSzGULJeIn
@BSParasitology@AmSocParasit @wiparasitology #trypanosomes
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Read the latest paper from @UoDLifeSciences @WCAIRDundee Anna Trenaman, Michele Tinti, Richard Wall & David Horn in @NatureComms
https://t.co/QSzGULJeIn
@BSParasitology@AmSocParasit @wiparasitology #trypanosomes
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Check out @JoanaRCF’s new and amazing work on VEX proteins, antigen variation and scRNA seq in Trypanosoma brucei.
(1/8) Very excited to share our latest work now published in @NatureComms. The result of a joint effort between Faria & Horn Labs! @YBRI_UoY @BiologyatYork @YorkBiolRes @UniOfYork @WCAIRDundee @UoDLifeSciences
https://t.co/i0fKWAgd6b
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Job alert! Any future PhD student interested on working with the liver fluke F. hepatica 🪱, its genetics 🧬 and drug resistance 💊? We are offering a PhD position at the Institute of Parasitology @unibern: https://t.co/vIMsaMRnwb Feel free to spread the word!
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Congratulations on the new paper! @FillingV and Zisis!
Happy to see this out - more exploration of #Microscopy to examine intracellular parasitism. #Parasites This time 3D holotomography with @Tomocubeinc
@DurBiol @Durham_BSI
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We are happy our review is out! If you are interested in the impact of nuclear organization on antigenic variation, check it out! We discuss the role of nuclear organization in mutually exclusive antigen expression and genome stability. https://t.co/VOzZ94QR2S
@NatureMicrobiol
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🧵(1)📢 Excited to announce our publication "Navigating Drug Repurposing for Chagas Disease" in @FrontPharmacol🌐 Our review explores cost-effective approaches to overcome drug development challenges for #ChagasDisease. https://t.co/iiaIBMh1PD
@DurhamChemistry @FillingV
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I’m sooo happy to see this work finally out! Congratulations to everybody involved, @Ariel_Lab and @Jana_Freitas. Cheers 🍻🍻🍻
Right now, out of the oven... I hope many people will find our estimations on the costs of building a trypanosome useful. Many congrats to everyone that participated of this adventure, in particular @jana_freitas
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Delighted that our work on a new series of Trypanosoma cruzi proteasome inhibitors is now published in @JMedChem. Brilliant team effort of @DDU_Dundee, @WCAIRDundee and @GSK. https://t.co/bvnW3cOIhz
#DrugDiscovery #ChagasDisease
pubs.acs.org
There is an urgent need for new treatments for Chagas disease, a parasitic infection which mostly impacts South and Central America. We previously reported on the discovery of GSK3494245/DDD01305143,...
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Please RT this fantastic fully funded 4 year PhD studentship open to UK/ Home applicants with Ehmke Pohl @DurhamChemistry @durbio in collaboration with @ccdc_cambridge. Closing date Friday 18th August. For full details please see advert:
findaphd.com
PhD Project - PROTACS: new computational methods, targets and experimental validation at Durham University, listed on FindAPhD.com
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Read latest paper from the Horn Lab. New data to understand the control of surface glycoprotein expression which helps African trypanosomes evade the immune system and persist in hosts. https://t.co/p6ZVGaUydh
@BSPparasitology @UoDRIS @SPPIRITnetwork @SULSAtweets @AmSocParasit
I am super proud to be part of this group and to be able to contribute to this wonderful work. Horn Lab @WCAIRDundee @PLOSPathogens @UoDLifeSciences
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(4/4) Our findings explain features of VSG population dynamics observed in mouse models that likely allow these #parasites to prolong immune evasion using a limited set of antigens.
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(3/4) Our findings reveal antigenic variation dynamics that is driven by the preferential activation of ES-derived VSGs followed by a subsequent advantage of populations of cells expressing minichromosome-derived VSGs! @parasitesrule
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(2/4) We used CRISPR/Cas9 to trigger VSG switching and generate a heterogeneous mixture of antigenic variants in cell culture. We then quantitatively monitored VSG abundance by RNA-Seq. @CRISPR_News
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I am super proud to be part of this group and to be able to contribute to this wonderful work. Horn Lab @WCAIRDundee @PLOSPathogens @UoDLifeSciences
(1/4) Happy to have contributed to this great work driven by @EscrivaniD and Viktor in the Horn Lab @WCAIRDundee and out today @PLOSPathogens! @UoDLifeSciences @ybri @BiologyatYork
https://t.co/nWBJGiX13i
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🎶 On the second day of Christmas, SULSA gives to you... Prof David Horn and Dr Melanie Ridgway @dundeeuni @WCAIRDundee talking about genome screening of Trypanosomes Read the paper https://t.co/7LaT3sBW9e Read the press release https://t.co/Mz8rQxwWy1
https://t.co/MChohc00WL
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Are you interested in cryoEM, proteomics & post-translational modifications? Don’t miss this opportunity! Co-supervised by @JNB_lab @Mottram_group @YSBL_York
https://t.co/ZliEVTjmHC
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