Siegel Lab
@siegel_lab
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We use T. brucei to study the role of chromatin and genome architecture in antigenic variation.
Munich, Germany
Joined April 2018
we have stopped using twitter/X. please follow us on @siegel-lab.bsky.social.
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RT @leslievosshall: Imagine if you woke up this morning and found that the NIH-funded database that holds all of the data that you and thou….
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RT @BSPparasitology: 🚨 #BSP2025 Spring Meeting: Joint meeting of @BSPparasitology, @SgtpSsmtp, & @DParasitologie! 🚨. - 1st time ever: the B….
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RT @parasitesrule: Registration and abstract submission is now open for the #KMCB meeting. Meeting will take place in Woods Hole, MA from S….
parasitesrule.com
Program (updated Sept. 5)
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RT @luisamfigueired: Hey Parasitology trainees, join us at the Kinetoplastid Molecular and Cell Biology meeting in September in Woods Hole.….
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Contact us, If you have any questions about a particular region of the genome or your favorite cell line. Some of these observations are discussed here: Cosentino et al NAR Genom Bioinform 3, lqab082 (2021).
academic.oup.com
Abstract. To date, most reference genomes represent a mosaic consensus sequence in which the homologous chromosomes are collapsed into one sequence. This a
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Working in Trypanosoma brucei using cell lines derived from Lister 427 strain?.We found several rearrangements in different clones, including full extra chromosome copies🧬, so keep that in mind!. 👀
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👀 Don't miss out on the super complementary "back-to-back" pre-print from @MonicaMugnier's lab, delving into mosaic VSG formation in vitro and in vivo!📰
biorxiv.org
Antigenic variation, using large genomic repertoires of antigen-encoding genes, allows pathogens to evade host antibody. Many pathogens, including the African trypanosome Trypanosoma brucei, extend...
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🌟Kudos to @KirstyRMcW, Zhibek Keneshkanova, and @CosentinoRaul for leading this remarkable endeavor! Dive in and share your thoughts!.
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🔍We have developed a highly sensitive scRNA-seq method, bridging genomic and transcriptomic changes. Our findings? The presence or absence of DNA repair templates is pivotal in the VSG selection mechanism.
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Ever pondered how the order of VSG expression is determined?🤔 Wonder no more! 🧬
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We’re thrilled to share our pre-print, unraveling the determinants of antigen expression hierarchy! @Cell2_Cell @ERC_Research @LMU_BMC A fantastic collaboration with the labs of @colomemaria_epi and @MonicaMugnier.🎉 Check it out ➡️
biorxiv.org
Antigenic variation is an immune evasion strategy used by many different pathogens. It involves the periodic, non-random switch in the expression of different antigens throughout an infection. How...
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RT @robert_ife: Publication alert ! Paper from in @Nature .How complex epigenetic modification signatures regulate….
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RT @HAKIMIMohamedA1: It's time to thank VEuPathDB and the dedicated people behind the screens who help us run great omics studies!.
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Here is the GitHub repo: Great work by @SchmidtMarkusR, Anna Barcons-Simon, and @claudia_rabu! .Thanks to our funders @crc_1064 @ERC_Research @dfg_public.
github.com
On-the-fly processing and visualization of interactome data - Siegel-Lab/BioSmoother
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In this paper, we use a prefix-sum index to process interactome data within seconds. On top of the index, we have built a GUI that allows interactive filtering (e.g. by mapping quality), various normalizations (e.g. ICing), and downstream analysis (e.g. virtual 4C).
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"Smoother: On-the-fly processing of interactome data using prefix sums" has been published in @NAR_Open.🥳Check it out to learn how #HiC and RADICL-seq data can be processed and visualized using an interactive interface. #Genomics #Bioinformatics
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RT @JoanaRCF: (1/8) Very excited to share our latest work now published in @NatureComms. The result of a joint effort between Faria & Horn….
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Great effort to understand the very complex genome architecture of T. cruzi.
Very happy! Our work was published! @fdiazviraque ML Chiribao, Gaby Libisch congrats! Thanks to @IPMontevideo @fmedoficial @FillingV .#Trypanosoma #chromatin #DNAmethylation #geneexpression .
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RT @GEWard14: Nina Papavasiliou and I are pleased to announce the program for the 2024 Host-Parasite Gordon Conference: .
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