Zeynep Erson
@ErsonZerson
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Assistant Professor@ Yale School of Medicine
New Haven, CT
Joined March 2014
Happy to share that our latest paper is published at @NatureComms. We’ve identified a novel subgroup of meningiomas defined by recurrent fusions in the FOS/FOSB genes, expanding the molecular classification of meningiomas. Read it at : https://t.co/nZvyT12N0r
#meningioma
nature.com
Nature Communications - Approximately 17% of meningiomas remain genomically uncharacterized. Here, the authors analyze 105 meningiomas without known driver mutations or significant copy number...
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Read the new study in @NatureComms which identifies a #meningioma subgroup with distinct genetic, transcriptomic, and clinical features, expanding the #MolecularClassification of meningiomas and opening new avenues for targeted treatment strategies: https://t.co/56UfoGu2TI
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Dear friends, The devastating Maras earthquake not only claimed lives of many , but also left many survivors with long term medical needs. This is a project that i am actively supporting to create solutions. Please consider donating. https://t.co/GGtISJV9hY
secure.givelively.org
Help The Child Amputees of Türkiye Earthquake (Project CATE)Support our efforts to provide prosthesis, physical therapy and long-term educationOn February 6, 2023 elev...
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New publication: our researchers conducted a comprehensive next-generation sequencing analysis on the molecular makeup of patients with multiple meningiomas. Read what they found here: https://t.co/ND91eulrFJ
#genetics #cancerresearch #braintumor
pmc.ncbi.nlm.nih.gov
Multiple meningiomas (MMs) rarely occur sporadically. It is unclear whether each individual tumor in a single patient behaves similarly. Moreover, the molecular mechanisms underlying the formation of...
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Our report on sporadic multiple meningioma genomics is out...
Genomic profiling of sporadic multiple #meningiomas
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We are excited, our new work is out! We are describing an mRNA isoform switch for the oncogenic activation of HNRNPA1 in breast cancers. #miRNA #RNA #isoformswitch @SciReports For more:
nature.com
Scientific Reports - Identification of an mRNA isoform switch for HNRNPA1 in breast cancers
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In a groundbreaking study published last week in @Nature, researchers have identified the role of the gene PPIL4 in a patient's risk of developing intracranial aneurysms, a deadly condition scientists are trying to understand better. https://t.co/Ivux5b8HGB
#medtwitter
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In our latest issue @Erson_BensanLab, @ozgursahin1905 & co-workers show that SNX3 loss is linked to EGFR overexpression in triple-negative #BreastCancers. 👉 https://t.co/dw6cjfSqpe
#TNBC
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Another (!) exciting mentored postgrad opportunity with @bulent_omay @YNeurosurgery and us in @thebabl @YaleCSC looking at multidimensional (brain, hormones, behavior) assessments of patients with pituitary tumors and TBI. Please DM us for more details!
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An article by @balcihasannn and @ugurdogrusoz2 on a new fast algorithm for automatic layout of compound graphs with support for user-specified constraints is just out: https://t.co/sW1ApbM6y4
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First publication on a rather mature pathway editor @newteditor. Congrats to all who contributed including @balcihasannn @AlexanderMazein @ozgunbabur @emekdemir @ugurdogrusoz2 @sbgnnews
academic.oup.com
AbstractMotivation. Visualization of cellular processes and pathways is a key recurring requirement for effective biological data analysis. There is a cons
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New paper alert 🔔: As part of continued efforts to understand the genetic underpinnings of cancer, researchers identified rare, somatic NF1 variants in two patients with pituitary adenomas in a new case study. 🧠 #cancertwitter #neurotwitter #genomics #neurosurgery #meded
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Another case from our group showing the importance of genomic profiling for every tumor.
New publication alert 🔔: A case study in @Nature_NPJ Precision Oncology of a rare #gliosarcoma patient reveals hypermutation. What are the implications for research and treatment? Find out: https://t.co/peqBnG40jS
#wes #genomics @ErsonZerson
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New paper characterizes spontaneous CSF leaks as a distinct variant of idiopathic intracranial hypertension (#IIH). Delayed measurement of opening pressure after leak repair may be helpful to diagnose idiopathic intracranial hypertension. https://t.co/PsIFtjWUQh
@bulent_omay
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Besides a kinase's own targets, which phosphorylation sites can be used to reason about the kinase's activity? https://t.co/LhOZQygDEG
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"Testing shows the presence, not the absence of bugs." – Edsger W Dijkstra
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Another collaborative work with @kahlelab : Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma
pubmed.ncbi.nlm.nih.gov
Similar variant allele frequencies of FGFR1 p.K656E and FGFR1 p.V561M mutations in our patient's tumor suggest that these mutations may have occurred at similar time points. Use of FGFR inhibitors in...
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Potential diagnostic utility of exome sequencing for congenital hydrocephalus.
A new paper from @kahlelab at Yale in @JAMAPediatrics uncovers many previously undefined mutations which could therapy and prognosis of congenital #hydrocephalus:
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In the first genomic characterization of a metastatic tumor to the sella, a case study of a 68-year-old with pituitary metastases suggests that PTCH1 and BCOR gene mutations may be involved in the pathophysiology of these diseases. https://t.co/QZArX5tLpn
#academicmedicine
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What if a blood test could tell you whether or not you would benefit from a shunt? Or A.I. could predict a causative gene mutation from the appearance of your brain MRI? Or we could correct congenital hydrocephalus in utero with gene therapy? Sounds crazy. Is it?
“A new era is approaching for increased accuracy of diagnosis & prognosis & improved intervention strategies for patients with this complex disease.” Thank you for your thoughtful words about our recent paper on #congenitalhydrocephalus, Dr. Ross! @WeillCornell @NatureMedicine
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