Kahle Laboratory
@kahlelab
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NIH-funded research at Harvard/ MGH on human genetics and molecular mechanisms of neurodevelopmental anomalies. Visit our website to get involved in a study!
Boston, MA
Joined September 2017
Moyamoya Disease patients & families, Join our NIH-sponsored study on discovering new genes in MMD! Participation does not require travel- it's free and easy. To get involved or learn more, visit: https://t.co/U5zGYJVEjG Kristopher Kahle, MD, PhD kahle_lab@mgh.harvard.edu
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Congrats to @kahlelab class of 2024 - Ben Reeves, Tyrone DeSpenza, @kedousmekbib, and @EmreKiziltug - moving on to bigger and better things: neurosurgery residency! Thank you gentlemen! @YaleMed @YNeurosurgery @MGHNeurosurg
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Vein of Galen Malformation patients & families, Join our NIH-sponsored study on discovering new genes in VOGM! Participation is free and easy. To get involved or learn more, visit: https://t.co/U5zGYJVEjG Kristopher Kahle, MD, PhD kahle_lab@mgh.harvard.edu
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Moyamoya Disease patients & families, Join our NIH-sponsored study on discovering new genes in MMD! Participation does not require travel- it's free and easy. To get involved or learn more, visit: https://t.co/U5zGYJVEjG Kristopher Kahle, MD, PhD kahle_lab@mgh.harvard.edu
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Overwhelmed with gratitude for the four young men from @kahlelab who matched today in neurosurgery - @tdespenza (@Dukeneurosurg ), Ben Reeves (@BarrowNeuro ), @EmreKiziltug (@umichneuro), and @kedousmekbib (@MayoClinicNeuro). I couldn’t be more proud+thankful for these soldiers!
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Vein of Galen Malformation patients & families, Join our NIH-sponsored study on discovering new genes in VOGM! Participation is free and easy. To get involved or learn more, visit: https://t.co/U5zGYJVEjG Kristopher Kahle, MD, PhD kahle_lab@mgh.harvard.edu
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Congenital Hydrocephalus patients & families, Join our NIH-sponsored study on discovering new genes in Hydrocephalus! Participation is free and easy. To get involved or learn more, visit: https://t.co/U5zGYJVEjG Kristopher Kahle, MD, PhD kahle_lab@mgh.harvard.edu
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Chiari I Malformation patients & families, Join our NIH-sponsored study discovering new genes in CMs! Participation requires no travel- it's free and easy. To get involved or learn more, visit: https://t.co/QLpakyGnjb Kristopher Kahle, MD, PhD kahle_lab@mgh.harvard.edu
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Excellent talk by Dr @KahleKristopher of @MGHNeurosurg on the utility of multi-omics in clustering and managing neurosurgical diseases like congenital hydrocephalus. Omics may be our generation’s surgical microscope @kahlelab
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Multi-omic analyses reveal de novo variants causing genetic neurodevelopmental conditions in up to 16% of cases of patients with cerebral arachnoid cysts, suggesting that surgery may not improve non-mass effect related symptoms @kahlelab @AdamKundishora
https://t.co/4wRTcA8f7i
nature.com
Nature Medicine - In a cohort of patients with cerebral arachnoid cysts, multiomic analyses reveal de novo variants causing genetic neurodevelopmental conditions in up to 16% of cases, suggesting...
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Congratulations to all team members behind this publication in @CellCellPress regarding the molecular mechanism of acquired hydrocephalus and resultant treatment considerations. @MGHNeurosurg @MGH_RI @BostonChildrens @broadinstitute
https://t.co/aMZr8y2YSq
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Genomic basis for the most common space-occupying brain lesion in humans. Congrats to Adam and other @kahlelab team members and @GeneDx and @PETERJIN999. Thanks to patients and their families! @MGH_RI @MGHNeurosurg
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Chiari I Malformation patients & families, Join our NIH-sponsored study on discovering new genes in CMs! Participation does not require travel- it's free and easy. To get involved or learn more, visit: https://t.co/U5zGYJVEjG Kristopher Kahle, MD, PhD kahle_lab@mgh.harvard.edu
kahlelab.com
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Motile cilia not primarily as CSF propellers but transducers of neural stem cell fate signals? Relevance for kids with hydrocephalus (and other disorders). Nice job @Phan_Q_Duy! @kahlelab @MGHNeurosurg @broadinstitute
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A new paper in @WorldNeurosurg explores the challenges faced by teens w/ #hydrocephalus when transitioning from pediatric to adult health care & highlights the recommendations that came out of HA’s Transition Summit. Read it for free for a short time!
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You can't do genetics without the involvement of patients and their families! A special thanks to those who have gotten involved in our NIH-sponsored studies on hydrocephalus, vein of Galen malformation, and others. THANK YOU - and blessings for health and joy in 2020!
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