Feyza Engin
@EnginLaboratory
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Associate Professor at the University of Wisconsin-Madison
Wisconsin, USA
Joined December 2017
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy | Nature
nature.com
Nature - Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes...
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Our new report with #YaChiHuang #MarjanRupnik using high-speed imaging in pancreatic slices. Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells | bioRxiv
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We are hiring! I am recruiting a postdoctoral fellow to join us studying cell stress responses and organelle communication in pancreatic beta cells. Cell and molecular biology background is highly desired. Interested? please contact me at fengin@wisc.edu. https://t.co/0PjYS4rYO4
hr.wisc.edu
Browse Postoc and Research Intern vacancies at UW–Madison.
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Mitochondrial origins of the pressure to sleep | Nature
nature.com
Nature - Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
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Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication: Cell Metabolism
cell.com
Tong et al. utilize advanced imaging approaches to reveal that beta cells located next to alpha cells are specially adapted as glucagon sensors by virtue of their high expression levels of GLP1R....
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ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science
science.org
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic,...
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Wow, fatty acid oxidation in neurons! Time to update the textbooks?!
A study in @NatMetabolism shows that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function. https://t.co/Z41DPxh2Fu
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If this is strictly true then it will devastate discovery science in fields like endocrinology and metabolism where there are no meaningful substitutes for physiological studies in whole mammals that can genetically modified in a tissue specific and temporally controlled manner
NIH no longer award funding to new grant proposals solely relying on animal testing.
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Very excited to share new work on the origins of beta cell senescence in #T1D led by talented PhD student @pipellaj 🎉🍾 online today @Diabetes_ADA
@CHRIManitoba @UM_RadyFHS
https://t.co/Cqs6gkxwa4
diabetesjournals.org
Type 1 diabetes (T1D) results from a complex dialogue between the immune system and islets characterized by T cell–mediated autoimmune destruction of pancr
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Yuzyilin beyin cerrahi, cok degerli bilim insani ve egitmen Prof. Dr. Gazi Yasargili kaybetmenin uzuntusunu yasiyorum. Saygi ve rahmetle…
Gazi Yaşargil Hoca 100 yaşında hayata gözlerini yumdu 20.yy’ın ikinci yarısının en önemli beyin cerrahı seçilmişti Modern beyin cerrahisinin, mikrocerrahinin kurucusudur Binlerce hastası, yüzlerce öğrencisi Hocayı, ilkelerini hep yaşatacak Ruhu şâd olsun https://t.co/oBHBx27S8R
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Excited to share our latest paper led by Renata Goncalves @RenataG81952725: CoQ imbalance drives reverse electron transport to disrupt liver metabolism. https://t.co/aEEgIEAIsU We uncover how altered CoQ redox balance triggers RET and rewires hepatic metabolism to offer
nature.com
Nature - Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty...
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Yine Mayis, yine Istanbuldayim ve yine Sampiyonuz. Hak ettigin sampiyonlugun kutlu olsun Galatasarayim 💛❤️. Harika bir geceydi. 🏆25⭐️⭐️⭐️⭐️⭐️
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Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease | bioRxiv
biorxiv.org
Mitochondrial endosymbiosis was a pivotal event in eukaryotic evolution, requiring core proteins to adapt to function both within the mitochondria and in the host cell. Here, we systematically...
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Wonderful work by my friend and colleague Maria Hatzoglou! Big congratulations!!!
nature.com
Nature - A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the...
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Mouse and human data suggests that a potent SCFA immunomodulator promotes multiple beneficial pathways and supports targeting the microbiota as an approach against #T1D
https://t.co/FXEW2ZRC17
@NatureComms
nature.com
Nature Communications - In a previous clinical trial, the authors reported that SCFA-yielding biotherapy in adults with type 1 diabetes remodels the gut proteome and metabolome. Here, the show that...
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In-cell architecture of the mitochondrial respiratory chain | Science
science.org
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain,...
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