Excited to share our new study out in @NatureCellBio! Led by postdoc @MikeLangePhD, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. https://t.co/QBM8e07IlC

FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online @embojournal I https://t.co/eOKTg6qVnk , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n

Glad to share our open access nature paper. Congrats to the three first authors and thanks to everyone involved! https://t.co/j3A1j5D5VJ

Hot off the press in@ImmunityCP! 🔥 Proud to share our new perspective — a collaborative effort with fantastic colleagues — proposing a unified framework to classify neutrophil subpopulations. #ThePowerOfMany 👉 https://t.co/cSK5cHssDM

Excited to share our new preprint! Exceptional work by postdoc @MikeLange identifies the first #LipidDroplet lipid quality control pathway! Droplet-localized FSP1 safeguards stored neutral lipids, blocking their peroxidation & #ferroptosis induction.🤩 https://t.co/x6OEzcSafI

#WeekendRead! #EveryCellIsAnImmuneCell! Kaelberer Bohorquez &co show @Nature that via #TLR5 flagellin drives neuropeptide PYY release by gut colonic neuropod cells, activating vagal neurons that signal to #brain, reducing feeding via a “neurobiotic sense”!

#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show @MolecularCell that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis!

Thanks for sharing @LabWaggoner 😌!!

New paper on the non-specific effects of BCG vaccine: Priming monocytes with BCG induces glycolysis and lactate production. This results in increased inflammatory cytokine release upon restimulation with LPS and is linked to p300-mediated histone lactylation that can persist over

#WeekendRead #InterferonsFriendsOrFoes?! @RuthFranklinLab @RMedzhitov &co show @ScienceMagazine that macrophage-derived oncostatin M overcomes type I IFN detrimental effects during influenza lung infections by driving AT-II epithelial cell proliferation!

In a new paper, we hypothesize that intradermal administration of BCG to the human newborn leads to low-grade bacteremia and that this systemic dissemination improves protection against tuberculosis. The hypothesis is based on supporting observations including animal and human

New preprint w/ the Dupage lab! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value & single-agent potential of FSP1 inhibition. A new paradigm for targeting ferroptosis in the immune system (not just in cancer cells). https://t.co/84JNnIdGXv

Happy to share our recent paper in @eLife showing the detrimental effects of β-Glucan in a murine LPS-model of lung injury This study was led by Renaud from @chubordeauxfr and incredible collaborators @erwan_pernet @kimaimytran Dr Poschmann @NantesUniv

Thrilled to share our study @ImmunityCP how a TB-vaccine (BCG) and a fungi fragment (b-glucan) synergistically train neutrophils against cancers A big shout out to @lfjuradoz the entire team and collaborators @JosefowiczLab @AjithaT4 @E_v_a_Kaufmann https://t.co/PrvPjdXx65

I am excited to share our new paper coming out in @ImmunityCP . Wish to thank everyone who made this dream come true, to the great @AdaGBB, to all the increíble team and the institutions that supported our work in these difficult times

#WeekendRead! #BeyondPRRs! Witt, Russel Vance &co show @Nature that SP140 at the same time inhibits DNA viruses but also represses RESIST destabilizing interferon-b RNA, linking antiviral effector triggered immunity to multiple sclerosis & B cell tumors!

#WeekendRead! #EveryCellIsAnImmuneCell! @bgyipp &co show @ImmunityCP that nociceptor neurons dampen lung fibrosis by blocking vasoactive intestinal peptide release by alveolar macrophages, preventing neutrophil recruitment & NETosis which sustains fibrosis

Online now: Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by @AMegarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Tweetorial! 1/9 https://t.co/9U7DSHJwIO

Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome! 📅 Abstract deadline: June 1, 2025. https://t.co/XF2CZdNJND