Ed Linossi 🔬
@Ed_Linossi
Followers
418
Following
3K
Media
16
Statuses
357
Postdoc in @JuraLab_UCSF |🇺🇸| Kinases | Signalling | Formerly @WEHI_research |🇦🇺| SOCS | SH2 domains | Putting people first in science = best science
Joined April 2012
You are what you eat! We leveraged chemical proteomics to discover that macrophages redeploy intact surface proteins made by their cancer cell meals during phagocytosis. These proteins are functional, and redeployment may explain the etiology of the TAM.
biorxiv.org
Macrophage-mediated phagocytosis is a vital innate immune process altered in cancer. We show here that tumor-associated macrophages (TAMs) redeploy intact cell surface proteins from cancer cells to...
1
12
34
😀Excited to share our new findings in @CellCellPress! https://t.co/X3nwkEhfjp Dynamic allostery drives autocrine and paracrine TGF-ß signaling #TGFbeta #DynamicAllostery #CryoEM #StructuralBiology #MedicalInnovation
4
6
20
Please RT! Postdoctoral position for 2 years @scienceANU - if you are interested in infectious diseases #StructuralBiology #Nanobodies please apply - new program on chytrid fungus 💎 🦙 🐸 Postdoctoral Fellow (Tham) - Canberra / ACT, Australia
0
41
48
Interested in Honours, Masters, or PhD studies in medical research? We have over 70 student research projects starting in 2025, across the breadth of research areas at WEHI. Explore the opportunities here: https://t.co/KKvDhaKxex
#WEHIStudents #StudyInMelbourne #UniMelb
0
13
22
I’m so very pleased to announce the opening of the LIMS Marilyn Anderson Fellowship application @LIMSLTU !!! in recognition of @ProfMarilynAnderson and in support of #WomenInScience Looking for high-achieving female scientist (level D) with a passion for molecular science
1
23
48
I'm very excited to share that I've been awarded a #DECRA fellowship to study how the gut microbiome impacts immune cells @MonashBiol. Its such an honour to receive this fellowship. Thanks to everyone who has helped me along this journey. #womeninSTEM
9
2
32
we are looking for a new Research Fellow at Ian Holmes Imaging Centre @Bio21Institute @UniMelb . If you are keen to expore new horizons and join a large electron microscopy facility this is for you. This is a continuing position. https://t.co/Iu7hARoeNk
0
12
17
In collaboration with @DavisLab_Oxford, published a study in @nature detailing cryo-EM structure of the gdTCR-CD3 integral membrane complex. Shows remarkable flexibility in this system https://t.co/OfLc52tm6f
@MonashBDI @MonashUni @benjaminsgully @arc_gov_au
3
19
44
As a scientist and science communicator, I'm appalled that Cosmos published AI generated articles and that it was funded by the Walkley Foundation. High quality science journalism is needed more than ever but it's being undermined by cost-cutting AI
abc.net.au
Cosmos Magazine's use of a Walkley Foundation-administered grant to publish AI-created content has drawn the ire of contributors and former editors, including its co-founders.
0
2
6
Mutations in the kinase domain of RTKs like MET can drive disease. Small molecule inhibitors target these mutations, but acquired resistance poses a challenge. In our latest preprint, we've extended our previous 🧬DMS of MET to study this exact problem.
biorxiv.org
Mutations in the kinase and juxtamembrane domains of the MET Receptor Tyrosine Kinase are responsible for oncogenesis in various cancers and can drive resistance to MET-directed treatments. Determi...
1
10
18
Join our team at @biomed_UCPH ❄️🔬We're hiring a 2-year postdoc in membrane protein structural biology and native nanodiscs 🌟 Exciting research, cutting-edge facilities, and a vibrant research community await you in beautiful Copenhagen 🇩🇰 Apply now!
0
24
44
Come work at WEHI Proteomics and collaborate with us!
An excellent opportunity for an experienced mass spec based proteomics post doc to join our @WEHI_research proteomics facility. More info here https://t.co/jcBmCJCDwx Applications close 9th August. Please share! #teamMassSpec
0
1
13
Come and join us @WEHI_research 👇
@WEHI_research is hiring! Share with your colleagues! Laboratory Head - RNA Biology
0
5
7
New paper alert! 13 protocols to spatially profile necroptosis in mice & human tissues – including in patients with IBD New methods = many surprises including RIPK3 going ⬆️ or⬇️ or↔️ in different disease settings Mega effort from many @wehi + @TheRMH
https://t.co/tBWHdMcqfu
embopress.org
imageimageNecroptotic cell death is broadly linked to inflammation-associated diseases such as IBD. But, accurately identifying when and where necroptosis occurs in human disease has proven difficu...
5
15
49
Easily some of our most important work. Hats off to @AndreSamson15 and team, including terrific first authors @shene67732453 and @aysha_h_alani Thanks to the wonderful support @WEHI_research and from @nhmrc and @KR_Foundation
New paper alert! 13 protocols to spatially profile necroptosis in mice & human tissues – including in patients with IBD New methods = many surprises including RIPK3 going ⬆️ or⬇️ or↔️ in different disease settings Mega effort from many @wehi + @TheRMH
https://t.co/tBWHdMcqfu
2
7
51
Interested in learning how dyes might help in characterizing protein activity? We're excited to share the development of a protein-adaptive DSF platform (paDSF), a dye-based method used to interrogate stability, dynamics, and ligand binding! https://t.co/uTANww2Vwc
nature.com
Nature Biotechnology - A library of fluorogenic dyes enables the measurement of protein unfolding for a large range of proteins.
0
19
63
Thrilled to share a pre-print describing an elegant solution to overcome target size limitation of single particle #cryoEM, where we demonstrate high resolution (2.3 – 2.5 Å) structure determination of small (~20 kDa) ordered proteins using cryoEM! https://t.co/FwLVozpT8G
5
49
204
Please RT and encourage students and early career researcher folks to apply for this fantastic ECR venom symposium! Join us for the 2024 venom GRS in beautiful Portland Maine from 10-11 August! #GRCvenom24 is 11-16 Aug! Register here:
Just ONE week left to get your abstracts in for oral & poster presentations for 2024 Venoms GRS! Join us for a welcoming and engaging symposium on cutting-edge venom science for students & early career researchers, run by ECRs! Register here: https://t.co/Lfjc2Tw8QH
#GRCvenom24
0
9
14
Awesome to see this fantastic study of the elusive EphB6 pseudokinase in print at long last https://t.co/jrI6AqZ1xL Massive congrats to star PhD student @LungYu_Liang (now in Frankfurt) who bravely took on this toughest of projects with @Isa_Lucet and me
2
6
56