RT @TheLancet: 👋 Introducing The Lancet Obstetrics, Gynaecology, & Women’s Health, a new journal dedicated to bridging clinical evidence an….

RT @MilaniLili: Excited to share our recently published overview of the @ESTbiobank 🧬.We highlight the unique features of the biobank and t….

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7/ Huge thanks to my amazing mentor @TLaisk and the brilliant PhD core teammates @jelisaveta_, Valentina Rukins – what a journey! 🚀 Grateful to @ESTbiobank @FinnGen_FI @genomicstartu, our collaborators & participants. Let’s keep pushing women’s health research forward! 💜.

6/ We also explored genetic risk prediction! 🧬 @FannyDhelia developed a PRS for intrahepatic cholestasis of pregnancy (ICP)—a serious pregnancy complication, which was replicated in the HUNT study by @bnwolford. The PRS showed comparable predictive power to breast cancer PRS.

5/ Population-specific genetic variants in Estonians & Finns helped identify novel genes for uterine fibroids. E.g. a missense variant in MYH11 which encodes for a smooth muscle myosin. A pop-specific focus is valuable, since it points at mechanisms relevant across populations.

4/ By analyzing cross-trait genetic & phenotypic correlations, we found shared genetic factors across reproductive health conditions. This is important because identifying shared genetic mechanisms provides insights into shared and disease-specific processes.

3/ We identified 195 genome-wide significant genetic signals, ~40% being novel. Notably, conditions with a metabolic component (e.g., some pregnancy complications) showed higher heritability (10-30%).

2/ We analyzed genetic data from ~300,000 women in the Estonian Biobank & FinnGen to conduct GWAS meta-analyses for 42 female health diagnoses. This helped uncover risk factors & biological mechanisms behind these conditions. Follow below! ⬇️

1/ The women’s health gap contributes to 75 million years of life lost. Yet, many female-specific conditions remain under-researched, limiting prevention, diagn. & treatment. We explore this using GWAS, which give hypothesis-free insights into biological processes.

📢 Excited to share our study in @NatureMedicine .👉 We mapped & characterized genetic risk factors for 42 female reproductive health diagnoses. What we found & why it matters? 👇🧵.

RT @ESTbiobank: Tremendous work by @PujolGualdo @TLaisk and team! 👏🏼👏🏼👏🏼.

RT @solsciencia: @Qabdany11 7/n).La Natàlia (@PujolGualdo ) ens va parlar de la partitura de la genètica i l’ajuda a estudiar malalties de….

som-hi! 🧬💙.

RT @researchestonia: 🔬 Natàlia Pujol Gualdo is tackling POP, PCOS, and AMH Levels for Women's Health! 💪. 🧪 She is delving into the genetic….

A fantastic day that sets an end to my PhD journey! 🥳 big thank you @TLaisk @m_reedik from @genomicstartu @unitartu + @terhip Riikka Arffman from @UniOulu 🇪🇪🇫🇮👩🏼‍💻🧬.

content to see this work finally out in Human Reproduction! 🥳 check it out! @terhip @TLaisk @UniOulu @unitartu.

☀️💙.

RT @SamuelBHume: Women are 4-times more likely to have autoimmune diseases than men. Why is this? . From Dou et al. in Cell, today . In fem….

our preprint is now out in Human Reproduction! joint work from @TLaisk @m_reedik myself + data from @ESTbiobank @FinnGen_FI .👇🏽 check out the tweetorial below from my wonderful mentor @TLaisk 😊👇🏽.

grateful for the chance to present our latest work studying the genetics underlying circulating anti-Müllerian hormone levels in pre-menopausal women 🤗 @aepcossociety.