Di Antonio Research Group
@DiAntonioLAB1
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We are a Chemical-Biology group investigating DNA structures and dynamics based at Imperial College Chemistry.
Imperial College London
Joined May 2019
We are hiring! We are looking for a PDRA to work on the epigentics of breast cancer dormancy through chemical biology and genomics approaches. This is a 3-year and aimed at a chemical biologist or a biologist. Please apply using the link below 👇👇👇 https://t.co/qxhWrDXYky
imperial.ac.uk
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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John Iredale kicking off our annual meeting. Auditorium is packed 😀 Record attendance!
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✨New preprint on genome-wide mapping of DNA G-quadruplexes in trypanosomes🧬 Led @imperialcollege & transition to PI @UniMelb with collab @UniOfYork & @LSHTM 👏🏻Congrats to my MSc student @gentafirth on 1st paper! @ChemistryUoM
biorxiv.org
G-quadruplexes (G4s) are non-canonical DNA structures formed in guanine-rich sequences that are proposed to act as regulatory elements in trypanosomatid parasites, including Trypanosoma brucei , the...
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Happy to share our latest preprint describing the first genome-wide map of G4s in T.Brucei led by the amazing @LudovicaMonti. We found that G4s accumulate in coding regions of the parasite, causing transcriptional perturbation upon treatment with ligands. https://t.co/BG5TtLWYXl
biorxiv.org
G-quadruplexes (G4s) are non-canonical DNA structures formed in guanine-rich sequences that are proposed to act as regulatory elements in trypanosomatid parasites, including Trypanosoma brucei , the...
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Fantastic new research from @DiAntonioLAB1 all about DNA's hidden shape unlocking chemoresistance in ovarian cancer! Read more:
imperial.ac.uk
REVERSING OVARIAN CANCER - An unusual DNA structure may hold the key to treating one of the deadliest cancers affecting women, which claims over 200,000 lives globally each year
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In 70% of cases, ovarian cancer develops resistance to chemotherapy. Researchers and charities like @OvarianCancerUK hope that this finding could improve ovarian cancer survival rates. Find out more via @TheObserver 🔽 https://t.co/XOellNI5GZ
observer.co.uk
Imperial College London scientists hopeful new approach could be used in other cancers
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Thank you @imperialcollege for highlighting our work. Link to the original research paper is here https://t.co/Y9cjXy3p3b
Unusual, four-stranded DNA could hold the key to fighting ovarian cancer, according to researchers. These DNA structures accumulate in the cancer cells that resist chemotherapy, so targeting them could give patients another chance of recovering. https://t.co/Bi5ceHzYVF
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Unusual, four-stranded DNA could hold the key to fighting ovarian cancer, according to researchers. These DNA structures accumulate in the cancer cells that resist chemotherapy, so targeting them could give patients another chance of recovering. https://t.co/Bi5ceHzYVF
imperial.ac.uk
REVERSING OVARIAN CANCER - An unusual DNA structure may hold the key to treating one of the deadliest cancers affecting women, which claims over 200,000 lives globally each year
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Very happy to see that The Observer has written a piece to cover our latest @GenomeBiology paper on ovarian cancer chemoresistance. @imperialcollege
https://t.co/fytQTMLhCN
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Ready for super-G4s? We identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells. These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s https://t.co/rIYJjeZwfM
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Happy Nucleic Acids Forum! Packed out at Burlington House today, as always. Great to see the new leadership team of the Nucleic Acids Group in action ❤️ @RoySocChem
@DrMikeBooth
@DiAntonioLAB1
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Proud supervisor moment. Very happy with Gem Flint from our group winning best presentation award at the Alternative Nucleic Acids Topology. A testament to her presentation abilities and great work! Well done Gem
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That was a lot of fun!
What do Senior Professors do at the Biennial G-Quadruplex #G4thering meeting? @DrZoeWaller @DiAntonioLAB1 @GaryNPark01
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What do Senior Professors do at the Biennial G-Quadruplex #G4thering meeting? @DrZoeWaller @DiAntonioLAB1 @GaryNPark01
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Always a pleasure to see Marco talk. This time telling us about ATENA at #G4thering @DiAntonioLAB1
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🚀 Ready to revolutionize healthcare? Join our MRes in Nanomedicine & Nanodiagnostics at @impchemistry! 🌟 Watch our video to see how we provide the perfect environment for your growth. #Nanomedicine #HigherEd #ImperialCollege #Chemistry
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🚨 Preprint alert 🚨 We have developed an entirely new mechanism of action for ASO gene knockdown -> lysosomal trafficking 🧬! Works with non-DNA ASOs (unlike RNase H mech) and higher activity than corresponding gapmers! Led by @disha_kashyap_ @UCLChemistry @OxfordChemistry
Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking https://t.co/PD4Kv8lKxZ
#chemrxiv_biochem
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We're seeking postdocs with a background in chemical biology, especially synthesis and screening. RNA expertise is a plus, but we'll train you! We Offer. Dynamic team environment; Opportunities to broaden your horizons in RNA biology. Part of a new RNA Center. Mdisney@ufl.edu
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Deadline #PhD position extended until 09.03 - Apply online👇🏼 https://t.co/hgVYjTd9IJ Please RT❤️ - Thanks
📢📢Official release #PhD position #OrganicChemistry at @Chemie_UMR & @mpi_marburg within Loewe consortium #RobuCop 🤖🦠 Apply online 🛜🛜 https://t.co/hgVYjTd9IJ 📆Deadline 22.12 - please RT♥️🙏
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The lab is now up and running at New England Biolabs @NEBiolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃
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