Matt DeJong
@DejongMatt
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PhD candidate in the @fordycelab and @Dunn_Lab. Past member of the Hackel lab @UMNews. Broadly interested in protein engineering. (he/him)
Joined April 2020
I am excited to share a major milestone of mine: my first publication! This wouldn't have been possible without all of the help, support, and mentorship from Professor Hackel and his lab, for which I am so grateful.
.@DejongMatt et al @UMNews report a new platform to find #antimicrobial peptides by tracking depletion of mutants that express active sequences, allowing them to find the sequence-activity relationship of 170,000 mutants of oncocin. #AMP.#deepsequencing
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RT @IsaacLiLab: I am excited to share our latest work on creating the first tunable Catch-Bond with #DNA! Our Fish-Hook architecture allowe….
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RT @fordycelab: Interested in intrinsically disordered proteins or transcription factor activation? Or purifying & measuring affinities for….
biorxiv.org
Sequence-specific activation by transcription factors is essential for gene regulation[1][1],[2][2]. Key to this are activation domains, which often fall within disordered regions of transcription...
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RT @Droplet_guy: 🚨 JOB ALERT 🚨. Join our team at Velocity Bio and help us unlock new drug discovery paradigms! . We're looking for a Senior….
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RT @fordycelab: What makes some proteins selective — binding preferred ligands more than chemically similar ligands — & others promiscuous?….
biorxiv.org
Transcription factors (TFs) bind DNA sequences with a range of affinities, yet the mechanisms determining energetic differences between high- and low-affinity sequences (‘selectivity’) remain poorly...
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RT @fordycelab: Very happy to see this published! A very cool collaboration with @NilssonLabCph and @KettenbachLab developing a new assay….
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RT @fordycelab: Please join us for the Next Generation Faculty Symposium THIS FRIDAY 11/17 from 10 am to 2 pm - check out this year's progr….
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RT @Dunn_Lab: New preprint! @vvachhar and @DejongMatt show that PDZ domains, innocuous-looking scaffolding domains that are enriched at cel….
biorxiv.org
Intercellular adhesion complexes must withstand mechanical forces to maintain tissue cohesion, while also retaining the capacity for dynamic remodeling during tissue morphogenesis and repair. Most...
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RT @fordycelab: It's out!!! Check out @connorh_sci's new paper in @ScienceMagazine about the surprising role of short tandem repeats in reg….
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RT @Stanford_ChEMH: What does predicting a protein's function from its sequence have to do with meteorology? For @fordycelab, it's the lang….
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RT @nicole_delrosso: My first😉first author paper just came out in Nature today🎉thank you to all the co-authors, collaborator Mike Bassik, a….
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RT @fordycelab: Happy to announce I was awarded tenure! Very thankful to all lab members past & present for driving great science & creatin….
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RT @Dunn_Lab: New preprint: @bri_zhong shows that pN forces can potentially activate latrophilin 3, an adhesion GPCR that regulates synapti….
biorxiv.org
Latrophilins are adhesion G-protein coupled receptors (aGPCRs) that control excitatory synapse formation. aGPCRs, including latrophilins, are autoproteolytically cleaved at their GPCR-Autoproteolysis...
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RT @fordycelab: How does the enzyme PafA accelerate reactions by 10^27-fold? Via High-Throughput Microfluidic Enzyme Kinetics (HT-MEK), Cra….
biorxiv.org
Using High-Throughput Microfluidic Enzyme Kinetics (HT-MEK), we measured over 9,000 inhibition curves detailing impacts of 1,004 single-site mutations throughout the Alkaline Phosphatase PafA on...
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RT @ACS_DivBioChem: Awesome news! Polly Fordyce @fordycelab @Stanford_ChEMH is the recipient of the 2023 Eli Lilly Award in Biological Chem….
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RT @NobelPrize: Just in! . First selfie from our 2022 #NobelPrize laureate in chemistry @CarolynBertozzi. Congratulations! .
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RT @naturemethods: BATTLES developed by @fordycelab is a method that uses spectrally-encoded ‘smart’ beads to apply biomechanical forces to….
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RT @Droplet_guy: Incredibly happy to be a part of this amazing group of scientists and Damon Runyon fellows! Many thanks to @DamonRunyon fo….
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RT @connorh_sci: 🎆Preprint alert from @fordycelab and team! 🎆.Short tandem repeats (STRs) are enriched in eukaryoti….
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RT @BMCBiology: An investigation into the optimization of the antimicrobial peptide Bac7 by deep mutational scanning. Read it here: https….
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RT @fordycelab: Do you like building microscopes? Enjoy hardware automation & image analysis for high-throughput assays? We're looking for….
schtqb.com
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