Chen Davidovich
@DavidovichLab
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Gene repression, RNA and all chromatin things. @MonashUni @EMBLAustralia
Melbourne, Australia
Joined July 2017
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 https://t.co/h5G9zTXNZz
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2/ Done in collaboration with the lab of @adrianbracken, who wrote a great 🧵 explaining the work.
1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. Excited to share our new paper https://t.co/TkvcVM26xi A thread 🧵
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1/ It's long been assumed that AEBP2 recruit PRC2 to chromatin. Now, we show that AEBP2 usually does the exact opposite: The only isoform of AEBP2 that is expressed in most cell types and tissues inhibits the chromatin-binding activity of PRC2.
embopress.org
imageimageAEBP2 is an accessory subunit of the PRC2 complex previously implicated both in promoting and antagonizing Polycomb repressive activity. This study reveals that its alternative isoforms,...
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1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. Excited to share our new paper https://t.co/TkvcVM26xi A thread 🧵
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🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on https://t.co/XrvHsiwtZh. Here's a thread with our findings!👇 #CancerResearch #Epigenetics #Chromatin #Lymphoma
biorxiv.org
The catalytic subunit of Polycomb Repressive Complex 2 (PRC2), EZH2, is recurrently mutated in 25% of diffuse large B-cell lymphomas (DLBCL), causing increased H3K27me3 and decreased H3K27me2 levels....
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Thrilled to see this out in @MolecularCell Led by the fantastic @sulteavn 👏 Revealing how PRC2 accessory proteins polymerise and shape gene regulation 🧬🌱 https://t.co/zr6pwFKA9b
cell.com
Schulten et al. show that VEL polymerization domains produce higher-order protein assemblies to maintain chromatin association of Polycomb proteins, enabling a stable epigenetic switch at the floral...
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🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. https://t.co/KGTUAZqHyS
biorxiv.org
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their...
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🚨 We’re hiring! Join @SAiGENCI in Adelaide as a Structural Biologist in my lab 🧬🔬 Use cryo-EM & biochemistry to unravel chromatin-associated complexes. 💰 $102k–$135k 📍 World-class facilities + Titan Krios access https://t.co/7z6ImKcLQ4
#cryoEM #structuralbiology #chromatin
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🚨 The Levy Lab at BGU is recruiting! We’re looking for passionate MSc/PhD students and postdocs to join our team exploring chromatin biology, epigenetics & lysine methylation signaling in health and disease. 🔬 Learn more: https://t.co/Sk8ZpuIZIc 📢 Please RT!
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We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. https://t.co/4TYHUgQEgd
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How we’re rebuilding the Weizmann Institute — and our hopes for a better future
nature.com
Nature - Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.
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Excited to share our MORC2 paper out in @NatureComms! Feel free to read the open access version here — https://t.co/STblTanLSk
Excited to share the 1st preprint from @ShabihShakeel lab @WEHI_research on oncoprotein MORC2 that is now available on bioRxiv! Here’s a thread on our main findings on how MORC2 phosphorylation influences DNA compaction and its implications in cancer🔬📜
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RT please 🙌 Applications for a postdoctoral position in *Bioinformatics* in my lab are still open! Come and work with us @ARMI_Labs at the beautiful @cityofmelbourne Apply here https://t.co/gviH3BXC5k Inquiries: nir.eynon@monash.edu
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Check out our (@Morpholosophist, @GATCLab and Alok Sinha ) thoughts on temperature sensing and response in plants out now @ScienceMagazine @MonashUni @MonashBiol @Monash_Science (1/4)
science.org
Plants are highly sensitive to temperature, and climate change is predicted to have negative impacts on agricultural productivity. Warming temperatures, coupled with a growing population, present a...
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🧵 1/ New preprint! How do transcription factors (TFs) use intrinsically disordered regions (IDRs) to find their target sites? https://t.co/ugZ1oQV4gu
#TranscriptionFactors #IDPs #SingleMolecule #Biophysics
biorxiv.org
Transcription factors (TFs) regulate gene expression by binding specific DNA motifs, yet only a fraction of putative sites is occupied in vivo . Intrinsically disordered regions (IDRs) have emerged...
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Up next in #CLASS: Dr Evan Healy, Monash University. In this seminar Dr Healy will discuss ‘Dissecting the roles of Polycomb repressive complexes in stem and differentiated cells’. All welcome. Tuesday 20th May at 12pm
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Australia completely lacks a dedicated training program for clinician scientists. With the vision and support of VMIAL @PeterMacCC is extremely proud to announce the first clinician-scientist fellowship. If you meet the eligibility criteria PLEASE APPLY! https://t.co/Pkihh7c1uy
nature.com
Peter Mac is launching Australia’s first clinician-scientist fellowship to advance cancer care, fostering innovation and global collaboration.
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Big thanks to @Addgene for making our MoClo Baculo available as a kit! All the plasmids for Golden Gate assembly of baculovirus vectors, now bundled together: https://t.co/pup3455P7m
#molecularcloning #baculovirus #ProteinExpression
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"Single-molecule multimodal timing of in vivo mRNA synthesis" a collaboration with Rippei Hayashi's lab, work led by AJ Sethi @_AJSethi #RNA #premRNA #splicing #RNAprocessing #m6A #polyadenylation
biorxiv.org
mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcr...
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🍺 Orchestrating epigenetics.... We have been working on SETD6 for a while now and I'm excited to share the review article we wrote 🧬 https://t.co/zYTQfNHWft
nature.com
Experimental & Molecular Medicine - The chemical modification of proteins, such as lysine methylation, influences their role in the cell. This review focuses on an epigenetic enzyme called...
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