Prof Danny Gale
@DannyGale_1
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Nephrologist @RoyalFreeNHS and rare disease researcher @UCL using genomics to understand kidney disease. @RenalRaDaR director.
Joined February 2017
šļø New episode of #KidneyCompass: Dive into the PARASOL Initiative with @LauraMarianiMD & @DannyGale_1 as they explore the potential of proteinuria & GFR as endpoints in #FSGS trials. Watch here: https://t.co/1UqFvg5zRz
#Nephrology #ClinicalTrials
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Congratulations Omid @OAlavijeh ! Iām delighted to see you win this very well deserved award and excited about what will come next in your career!
š¢ Big news! Dr Omid Sadeghi-Alavijeh @OAlavijeh has won the prestigious Raine Award & will deliver the lecture at UK Kidney Week 2025! His talk will focus on the genetics of inherited kidney diseases, offering key insights from whole-genome sequencing. š§¬ #Genetics #RareDiseases
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Missed the PARASOL Scientific Workshop? Learn about the findings on FSGS endpoints @ASNKidney #KidneyWk from @LauraMarianiMD, @DannyGale_1, Abigail Smith, Aliza Thompson, Josh Tarnoff and @NewKidneysOTB. Session Friday, poster Saturday https://t.co/NxYeomKI4L
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Just published in @JASN_News - our long-term outcome analysis of rituximab in podocytopathies: https://t.co/9Cbx1btoIw A special thank you to my partner in crime @GaucklerP and my fantastic past @ERAkidney fellow Anna Matyjek. This has been work over the past 6 years!
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PARASOL news from the Scientific Workshop with @US_FDA. Stay tuned for more updates at #KidneyWk2024! (translational session at 4:30 Friday 10/25) #FSGS #KidneyHealth #ResearchRevolution
https://t.co/cPl7jwycU1
@nephcure @nkf @MiKTMC @ASNKidney
is-gd.org
A group of RKD experts aligned around a potential proteinuria-based clinical trial endpoint, balancing biological relevance and trial design considerations.
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This comprehensive analysis of variants in cystic kidney disease leveraged 100,000 genomes! https://t.co/FbzWNLhpou
@Oalavijeh @DannyGale_1 & team highlight the contributions to disease risk of different types of variants across the allelic spectrum.
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The fantastic @LauraMarianiMD revealing data-derived trial endpoint proposals to allow feasible clinical trials in #FSGS #ParasolProject @ISGDtweets
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This is a tragic and devastating loss to UCL, the Royal Free Hospital, RaDaR and the renal community everywhere. It is a particular loss to his patients for whom he was such a champion. My thoughts and deepest condolences are with his family at this terrible time.
We are heartbroken to announce that Prof (Stephen) Ben Walsh, died peacefully on 30th Sept while surrounded by family & friends. Both his family & @RenalUCL are raising funds to find a way to honour his memory and achievements. More info below: https://t.co/aehrXRNkF8 Ben's
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Delighted to share our latest @GrekaLab story in collaboration with @WuLabHarvard on the molecular basis of TMED9 cargo receptor oligomerization and entrapment of misfolded cargo in the early secretory pathway. @broadinstitute @harvardmed @MassGenBrigham
https://t.co/2oJMjGdr1E
science.org
Cryo-EM structures reveal TMED9 oligomerization and interaction with misfolded proteins to exert cytotoxicity and disease.
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Increased risk of kidney failure in patients with genetic kidney disorders @CureGN
https://t.co/nBVNnHcYeL
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Fantastic to see this #statisticalgenetics tour de force by @OAlavijeh using @GenomicsEngland #WGS to explore #ADPKD #ARPKD out in @jclinicalinvest š§¬ Novel associations with COL4A3 and monoallelic PKHD1 variants š§¬ 3-9% heritability explained by common variants
The primary piece from my PhD on cystic kidney disease is out today in @jclinicalinvest! https://t.co/N4iFMaR67P The full thread discussing the paper is linked in the tweet below. As always many thanks to @The_MRC and @GenomicsEngland, @RenalGenomics and many more!
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8 days left to apply! This second call welcomes research ideas that could help us to understand the impact that Alport syndrome has on hearing and sight as well as kidney problems. Find out more and apply here: https://t.co/oNWaiVf97N Closes 4 Sept. @DannyGale_1 @RLWczyk
kidneyresearchuk.org
Funds standalone research projects into Alport Syndrome that has the potential to transform the outcomes for Alport patients
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Well done Omid @OAlavijeh - great to see this published!
The primary piece from my PhD on cystic kidney disease is out today in @jclinicalinvest! https://t.co/N4iFMaR67P The full thread discussing the paper is linked in the tweet below. As always many thanks to @The_MRC and @GenomicsEngland, @RenalGenomics and many more!
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In 2001 KDOQI said all kidney patients had the same disease, CKD, and we should differentiate them based solely on GFR. This was never true, and this study does a wonderful job exposing the lie. #nephjc (Me channeling @melhoenig who taught me this)
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Two weeks to go until our Alport Research Hub Symposium where professors @RLWczyk, @DannyGale_1 and @neilturn discuss the latest news and approaches to Alport syndrome. Not registered? Click here: https://t.co/i0i5Chdhrb
@alportuk
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Delighted to share our latest research using multiscale topology to classify cells in subcellular spatial kidney transcriptomic data @Nature in collaboration with @haharrington @kfbenjamin @OxUniMaths
https://t.co/Jgk3fUSvHp
nature.com
Nature - A method for topological automatic cell type classification across subcellular resolution spatial transcriptomic platforms is proposed, resolving cell type information and locating...
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Yesterday @UKLabour published its manifesto. We welcome a number of their commitments including to develop an NHS innovation and adoption strategy in England to include faster regulatory approval for new technologies and medicines #GeneralElection2024
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Clinical trials are underway to evaluate novel agents targeting the alternative complement pathway in patients with C3G. @KidneyHealthIn's C3G Trial Endpoints Work Group assessed prespecified endpoints as measures of clinical benefit in these trials https://t.co/IRiRoPHMy7
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Fantastic for @RenalRadar team to work with registries, stakeholders and experts from multiple countries to catalyse clinical trials in a rare kidney disease. Go Team Kidney!
Bringing together the PARASOL team in Reykjavik with a dash of midnight sun (sunset photo from 1 am) to make progress on FSGS!
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