Join us tomorrow 9pm EST only on #BlueSky.We will be discussing the use of spironolactone in patients on dialysis to prevent cardiovascular 🫀outcomes and heart failure hospitalizations 🏥. Invite your friends! #NephJC #Nephtwitter.

Check out the ACHIEVE visual abstract by @DrAkshayaJ .#NephJC #Nephtwitter .

It's finally here!!.#NephJC summer book club 📚.Everything is Tuberculosis by @johngreen .8/19/25 @ 9pm EST, only on #BlueSky.Come for the discussion, stay for stories.

😎Check out the VA for HiLO by @sejalplakhani 🆒.#NephJC #NephTwitter.

Find us at #Bluesky for discussion 8/5/25 at 9 pm: @nephjc.bsky.social.

My family will not be hearing from me

HiLo, HiLo it's off to work we go! ⛏️.Join us 9 pm EST 8/5/25. #NephJC #NephTwitter.⬇️ Phos in patients on HD is a lot of work, but is it worth it? HiLo looks at hospitalization & death in low/high Phos goals. Will we finally have a RCT with answers ⁉️.

👇Read last #NephJCshorts by @hswapnil . ✍️On CKD screening cost-efficiency in the general population . 🎨 #VisualAbstract by @NephroSeeker.

RT @anuja_java: Another major milestone for our C3G patients & community!!. C3 inhibitor, Pegcetacoplan approved for C3G and IC-MPGN 🧬💊. ht….

10/ Final thoughts.👉eGFRdiff is still an enigma but may have prognostic implications.👉eGFRdiff is just based on estimates (caveat emptor). ➡️Up next: HiLo & phos control in ESKD #TenPostNephJC by @AgavriloaeiB.

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9/ I want more info. ✅Check out #NephJC summary by @DrAkshayaJ @roxnonna23, Janany Sabescumar. ✅Visual abstract by @DrAkshayaJ and @DrSaiVani1 . 📍Spanish VA, translated by @dra_miliflores .

8/ #NephJC Quote of the fortnight. eGFRdiff is derived from eGFR. We calculate eGFR by various molecules and equations, but in the end it is probably not very accurate at the individual patient level

7/ Chat consensus?. ⚠️ eGFRdiff could be a marker for frailty. 👎 Negative eGFRdiff (eGFRcr >> eGFRcys) is a marker for worse prognosis. 💡The exact cause of eGFRdiff is not well defined by muscle mass, inflammation, or filtration characteristics.

6/ Give me something clever to say 🤓. 👇@kidney_boy and @GrahamAbra summarize the utility of eGFRdiff nicely

5/ A figure paints a 1000 words! 🖼️. For each 10 mL/min ↑ in eGFRdiff. 🚨20% ↓ mortality risk (AHR 0.80, 95% CI 0.74–0.88). 🚨17% ↓ HF risk (AHR 0.83, 95% CI 0.73–0.94). ✅ Association held after adjustment for muscle mass & filtration markers

Zohran Mamdani: He votes for activists, not you

4/ One post results. ⚠️A more positive eGFRdiff was assoc with ⬇️death risk (aHR 0.8, 95% CI 0.74–0.88)& hospitalization for HF (aHR 0.83, 0.73–0.94). 🤔Final model with all determinants (muscle mass, inflammation, shrunken pore, BMI) only explained 36% of eGFRdiff variance.

3/ One post methods. 👥1,290 pts with chronic kidney disease from CRIC cohort, followed for a decade.⚙️eGFR- estimated using both cystatin C& creatinine.⏩eGFRdiff- analyzed to assess its association with clinical outcomes: all-cause mortality& hospitalization for heart failure.

2/.What'd I miss?. The risk of death and hospitalization for heart failure has been associated with eGFRdiff, showing potentially important prognostic value, even though it is only partially explained by factors such as muscle mass, inflammation, or molecular clearance.

Last #NephJC we discussed the significance and causes of eGFRdiff, the difference between eGFR creatinine and cystatin C (eGFRdiff= eGFRcys-eGFRcr). #TenPostNephJC #NephTwitter. Read the article 👇.

⏰July 22nd, 9 pm EST, see you with the lively chat on 🦋. Until then, take one more look at the first #visualabstact @DrSaiVani1 and @DrAkshayaJ made for #NephJC🤩

Check out the Spanish version of the VA by @dra_miliflores on eGFRdiff in the CRIC cohort. #NephJC #NephTwitter.

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