daniel_reichart
@danielreichart3
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Cardiology LMU Munich | Postdoc@Seidman Lab | Harvard Medical School | scRNAseq
Joined December 2019
Excited to see our new story @ScienceMagazine! 881,081 nuclei from healthy and diseased hearts were deeply characterized with insights into shared and distinct signatures across genotypes! Amazing team work, @ericl_lindberg
@HenrikeMaatz @HMSGenetics
science.org
A single-cell atlas of the heart identifies cellular interactions and pathways involved in two types of cardiomyopathy.
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Day 2 #PCHFLondon2024 @zhh_ch @TomLuscher @eleanorwicks @RuthAmstein @johncleland Treatment (old & the new). @WilfredMullens #diuretics in #heartfailure Takehome messages: 👉Spot-natriuresis in AHF is safe 👉Use loop diuretic ± acetazolamide to achieve effective natriuresis
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Fünf für München: Provinz, Pumpenforschung, Poetry-Slam via @sz
sueddeutsche.de
Brandon Miller hat beim Bundeswettbewerb für Musical gewonnen, Anna Aichers Fotoband wurde ausgezeichnet.
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From AI to the Y chromosome (and everything in between) Our editors pick their favorite research articles from 2023 https://t.co/zZlmATaXVP
https://t.co/aCYn6EUws8
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🎇🥳Happy to share that Daniel Reichart has been awarded with a funding of two million euros by the German Research Foundation through its Emmy Noether Programme. Congratulations, Daniel!🥂 Welcome as new research group leader @GeneCenter_LMU 🤗 @danielreichart3 @LMU_Uniklinikum
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Congrats! The German Research Foundation @dfg_public is awarding four LMU researchers through the Emmy Noether and Heisenberg programs for their #research. @danielreichart3 @JCHalimeh @benjkraemer @LMU_Uniklinikum
lmu.de
The funded projects deal with new biomarkers of ageing, quantum simulations, the journey of immune cells through the body and media usage strategies.
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Today we report in @NatureBiotech the development of dual-AAV in vivo delivery systems for prime editors that can support efficient prime editing in multiple organs such as brain, liver, and heart. 1/4
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Today we report in @NatureMedicine a study led by Christine & Jonathan Seidman’s lab in which we used adenine base editing in vivo to correct a common mutation that causes hypertrophic cardiomyopathy (HCM), a disease that occurs in ~1 in 500 people (1/8)
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Exciting to see genome editing of hypertrophic cardiomyopathy to correct the pathogenic variant in the humanized mouse model, laying the groundwork for a potential cure in the future https://t.co/mB4obCSMnJ
@NatureMedicine @Transactivator @andreas_c_chai @UTSWNews
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A 2nd @NatureMedicine report today showing prevention of hypertrophic cardiomyopathy in mice via genome editing, reinforcing the potential of a single-dose to cure the most common genetic heart disease https://t.co/S8lqnjRyJt
@davidrliu @danielreichart3 and colleagues @harvardmed
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Happy to share our latest paper on a broad new application of CRISPR for treatment of heart disease. Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease https://t.co/ZOFmPgebXr
@UTSWNews
science.org
Removing oxidative activation sites in CaMKIIδ by base editing sustains heart function after ischemia-reperfusion injury.
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Harvard’s Dr. Christine E. Seidman to Receive the 2022 Research Achievement Award, the Association’s Highest Honor
newsroom.heart.org
Embargoed until 7 a.m. CT / 8 a.m. ET Wednesday, Oct. 26, 2022 DALLAS, Oct. 26, 2022 – The American Heart Association is presenting its 2022 Research Achievement Award to Christine E. Seidman, M.D.,...
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Excited to share results from a collaboration with @md_timberlake and many others to study genetic basis of craniofacial microsomia #CFM and #microtia in @GIMJournal. A thread 👇 https://t.co/m3CcoDtQwB
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Boston RT party!🧬So excited about our #CRISPR prime editing work, out @NatureBiotech today – great @JoungLab team work w/ Bret Miller, @ReganSzalay, @johnASeed1, Chris Woodilla, @elizajaneholtz, @Karl_Petri & @JKeithJoung
nature.com
Nature Biotechnology - A split prime editor architecture facilitates screening and engineering of improved variants.
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Extremely excited to kickstart my lab @TU_Muenchen with Emmy Noether support from @dfg_public. I’m very grateful to @JKeithJoung, my friends in Boston, and to A. Moretti, K.L. Laugwitz & C. Kupatt in Munich. More details & website coming soon. #CRISPR 🫀
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On this week's episode: an atlas for #HeartFailure 🗺️ 🫀 @DanielReichart3, @EricL_Lindberg, Henrike Maatz, & their colleagues performed #SingleNucleus #RNAseq on heart samples with & without #cardiomyopathies. @ScienceMagazine
https://t.co/8VHcNDgPYi 🎧 https://t.co/6cF965FL2C
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#snRNAseq of ventricles from heart failure patients reveals distinct transcriptional states in #cardiomyopathy. Eg, #fibroblasts exhibit differential gene expression that promotes remodeling of the extracellular matrix. @danielreichart3
https://t.co/vgyb6rwNbL
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The data of our recent heart failure snRNAseq study (@danielreichart3, @HubnerLab, @MDC_Berlin) are now online. You can discover the files via @cellxgene, download processed objects, or raw data. @cziscience @CZCellxGene
https://t.co/PCT743yA0G
cellxgene.cziscience.com
Find, download, and visually explore curated and standardized single cell datasets.
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Laying the groundwork for individualized, molecular basis interventions for some people w/cardiomyopathy and heart failure, using snRNA https://t.co/HPXuCQZ13p
@ScienceMagazine @danielreichart3 @ericl_lindberg @HubnerLab @MDC_Berlin
https://t.co/vVxZ5MyypP
@statnews @cooney_liz
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Researchers pinpoint genetic defects that cause heart failure, pointing the way to more targeted treatments Folio
ualberta.ca
An international research team has identified individual genetic defects that cause heart failure, opening the door to more targeted diagnoses, preventive measures and treatments.
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