Thomas Lab
@DThomasLab
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We study the role and regulation of NADPH oxidases in immunity - https://t.co/NGi4HtxMNN
United Kingdom
Joined February 2021
Our latest paper on EROS has now been published in @eLife! A great collaborative effort @fra_magnani and many more!
elifesciences.org
Biochemical and cellular analyses reveal the mechanism by which EROS regulates NOX2 and P2X7 abundance in mouse and human.
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Delighted to be co-leading this collaboration with Nic Wisniacki at GSK.A £50million plus investment in towards a better understanding of renal and respiratory disease. More here:.
cam.ac.uk
The Cambridge-GSK Translational Immunology Collaboration (CG-TIC) combines University and GSK expertise in the science of the immune system, AI and clinical development with access to patients and
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Very exciting paper from @ALNeehus and @casanova_lab.
1/ Exactly one year after my PhD defense, I am very excited to share with you the last chapter of my thesis published today in @Nature about humans with inherited TNF deficiency:
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this is an excellent opportunity!.
Interested in #genomics? Fulled funded UKRI PhD studentship available in @lab_peters at @imperialcollege London. UK Home students eligible for this scheme.
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UK transplant will miss the wonderful @frank_dor - good luck in your new post and come back often !.
Dear @RotterdamTrans, thank you for loaning @frank_dor to London for the last few years. Frank, thank you for everything. We will miss you. Don’t be a stranger! 😘.@Bynvant @KessarisN @KikiSran @CityUrology @Mr_G_Papadakis @CJCallaghanTx @LoukopoulosI @rhz59 @PGogalniceanu
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@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab Finally, we identified a population of transcriptionally distinct monocytes that emerged in peripheral blood following glucocorticoid treatment - the “dex monocyte” do have a read !.
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@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab Evaluation of clonal T cell dynamics showed that the fastest expanding clones were significantly enriched in known SARS-CoV-2 specific sequences and shared across multiple patients. Our analyses also revealed novel TCR clones that are likely reactive to SARS-CoV-2.
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@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab We identified gene expression signatures of severity, with the majority of pathways differentiating mild from severe disease in B cells and monocytes.
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@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab We used single-cell RNA-seq, CITE-seq and immunoreceptor sequencing, derived from 187 longitudinal samples from 61 patients.
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@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab We collected samples before and during COVID-19 infection from the same individuals. We performed dense longitudinal sampling during infection, allowing us to study intra-individual changes over time among patients with a wide spectrum of COVID-19 severity.
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@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab We studied two cohorts of end-stage kidney disease patients prior to the introduction of vaccination. This is one of the patient groups most at risk from severe COVID-19.
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delighted to have worked with @lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab on this study. great work by first authors Emily Stephenson, Lisa Dratva and Erin Macdonald-Dunlop. Thanks to all our patients most of all.
Our study on severe #COVID19 in end stage kidney disease patients with matched pre-pandemic samples from a broad cohort of 61 individuals is on medRxiv!
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Great opportunity !.
I'm recruiting a Postdoc for a comparative innate immunity project to define cross-species mechanisms of pathogen sensing, in collaboration with @ClareBryant13 and Sandhya Ganesan. Can involve travel to partners in India. Please RT. Full advert here:
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RT @drbstewart: A privilege and honour to receive the Raine award and I hugely enjoyed sharing our science at #UKKW2024.
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@Dr_James_Lee The paper outlines the central role of ETS2 in driving macrophage inflammatory responses, dissects how this distal enhancer for ETS2 expression is a risk locus in numerous genetic studies and outlines new therapeutic possibilities in IBD. Even a bit of ROS too !.
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So great to see this work published and delighted to have collaborated with the Lee lab. Fantastic work from Christina Stankey, Christophe Bourges, Lea Maxie Haag and colleagues, led @Dr_James_Lee .
nature.com
Nature - ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human...
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RT @NEJM: In this study, interferon-γ was found to play a large role in the pathogenesis of APS-1. Results were confirmed in studies in ani….
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2/2 - it's on the role of EROS in endothelial cells - our favourite protein takes on some different roles outside the immune system!.
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Delighted to share our new paper - a fantastic collaboration with Markus Waldeck Weiermair, Thomas Michel and the brilliant Michel lab at Harvard.
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