Peters Lab
@lab_peters
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Research group working at the interface of molecular epidemiology, computational biology and clinical medicine. Focus on inflammation, #lupus & #vasculitis
Imperial College London
Joined May 2021
Our multi-omic study on COVID19 in ESKD now published in @CellGenomics. Single-cell transcriptome, surface proteome and immunoreceptor sequencing of longitudinal samples, including paired pre-infection and acute infection samples
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Blood protein profiles provide new insights into large-vessel vasculitis
imperial.ac.uk
VASCULITIS - Researchers found that blood profiles of two vasculitis diseases are similar, indicating an overlap in the biology of these diseases.
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RT @ACR_Journals: Plasma @OlinkProteomics study of large vessel vasculitis spectrum revealed.•Highly similar proteomic signatures in Takaya….
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Excellent series of immunology articles in @ACR_Journals covering complement, interferon signalling and SLE pathogenesis and CAR-T treatment:.
acrjournals.onlinelibrary.wiley.com
Arthritis & Rheumatology, an official journal of the American College of Rheumatology, is a peer-reviewed rheumatology journal of the rheumatic diseases.
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Interested in #genomics? Fulled funded UKRI PhD studentship available in @lab_peters at @imperialcollege London. UK Home students eligible for this scheme.
Interested in a career at the intersection of data science, biology and medicine 📈🤓? @lab_peters have an exciting opportunity for an UKRI funded PhD studentship: ⬇️.
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Very nice summary of the state of play and perspectives on the future direction of autoimmune disease treatment strategies from @rplenge and colleagues
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Position available (senior lecturer, reader or Prof) in Dept of Immunology at Imperial College London for clinical or non-clinical scientist in renal medicine/immunology: .
imperial.ac.uk
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Very nice paper cautioning on uncritical application of #Mendelian_randomisation.
Review: "Use of Mendelian randomization to assess the causal status of modifiable exposures for rheumatic diseases" led by @SteZhao that was a pleasure to contribute to. Great take on where we are currently with MR particularly focused on rheumatology:
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RT @teichlab: Our study on severe #COVID19 in end stage kidney disease patients with matched pre-pandemic samples from a broad cohort of 61….
medrxiv.org
Summary Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. We performed longitudinal single cell multi-omic immune profiling of ESKD patients with COVID- 19, sampled...
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Interested in a career at the intersection of data science, biology and medicine 📈🤓? @lab_peters have an exciting opportunity for an UKRI funded PhD studentship: ⬇️.
findaphd.com
PhD Project - Integrative proteo-genomic analysis to investigative immune-mediated disease aetiology at Imperial College London, listed on FindAPhD.com
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Our work examining molecular effects of imatinib in COVID19 using @SomaLogic proteomics now out in @NatureComms Great collab with Erik, Jurjan and colleagues from Amsterdam, leveraging randomisation from clinical trial to understand molecular mechanisms.
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Spot the difference? The pQTL-eQTL #colocalisation was so strong, we missed the problems on the proofs. now corrected
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@aidanbutty #MendelianRandomization suggests role of CXCL5 in aetiology of ulcerative colitis (UC) but not Crohn's disease (CD). Collaboration with @NickPowellLab showed ⬆️ CXCL5 expression in UC gut samples > CD > healthy. But interesting paradox of MR direction of effect - see Discussion!
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@aidanbutty 1) Examples include disease-protein pairs that mirror existing therapies (e.g. IL-12B and IBD -> ustekimumab). 2) Note directional discordance across IMDs: genetic predisposition to higher CD40 increases rheumatoid risk but protective against multiple sclerosis and IBD.
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@aidanbutty By combining #pQTL and disease #GWAS in a #MendelianRandomisation framework we identify proteins that play a causal role in development of immune-mediated diseases (#IMDs).
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Our study mapping genetic determinants of inflammation-related proteins in 15,000 people now out in Nature Immunology Made possible by multi-national collaborative #SCALLOP consortium and leadership of @aidanbutty #pQTL #MR #GWAS.
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Exciting position for a Research Assistant working in Immunology at Imperial College London:
imperial.ac.uk
Join Imperial and be part of a world leading community of research, teaching and innovation.
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RT @thebarneslab: We're excited to partner with @benevolent_ai to revolutionize the treatment of inflammatory diseases using cutting-edge #….
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Sharing our pre-print: #pQTL mapping and #Mendelian_randomisation for inflammatory proteins in 15,000 participants as part of the #SCALLOP consortium. Novel insights into immune diseases. Thanks for great collaboration to all the team!.
medrxiv.org
Circulating proteins play key roles in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative...
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Congrats to @Neely_Lab on their work showing that #LRRC15 is an alternative SARS-CoV-2 receptor.
Our new SARS-CoV-2 receptor paper is out: work done by @LLTheResearcher @M_A_Waller @CPC_usyd @SydneySOLES. - We found a new human receptor that can bind SARS-CoV-2 Spike, suppressing infection, turns on antiviral responses, and turns down collagen.
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