Chenoweth Lab
@DMChenowethLab
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Student-run twitter account for the Chenoweth Lab at University of Pennsylvannia. Chemical Tools, Fluorophores, Nucleic Acid Binding Molecules, Collagen.
Philadelphia, PA
Joined April 2019
RT @rachlack: Yesterday I successfully defended my PhD @PennChemistry. Eternally grateful for the people who made these last 5 years a litt….
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Check out the group's latest paper out of our collaboration with @molandergroup ASAP @JOC_OL. Congrats Mike and Mo! @PennChemistry .
pubs.acs.org
Forging new C(sp3)–C(sp3) bonds to central positions within a peptide backbone is critical for the development of new therapeutics and chemical probes. Currently, there are no methods for decarboxy...
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RT @buenoscience: Thanks to all the fantastic current and former members of my lab whose efforts made this possible! Excited about where we….
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Our latest work is officially up at @ChemBioChem! @PennChemistry.
A General Strategy for the Design and Evaluation of Heterobifunctional Tools: Applications to Protein Localization and Phase Separation (Zhang, Chenoweth) @lab_zhang @CarnegieMellon @DMChenowethLab.
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RT @rachlack: Today was my last lab day before I move to NYC. I’ll be back to defend my thesis but until then I’ll miss my friends in the @….
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Check out the latest paper from the group! In collaboration with @lab_zhang, we developed an assay to study the "linkerology" of chemical dimerizers and applied a new tool to control phase separation.
If you are interested in chemical biology, check out our new paper in collaboration with Chenoweth lab where we optimized the linker for our TMP-Halo system for fast dimerization and applied it to control phase separation in cells.
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RT @lab_zhang: If you are interested in chemical biology, check out our new paper in collaboration with Chenoweth lab where we optimized th….
chemistry-europe.onlinelibrary.wiley.com
Linkerology 101: This work presents a quantitative method for the rational design of tools to control protein-protein interactions. A library of probes based on the Trimethoprim-HaloTag system was...
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RT @NJP_Chem: Thrilled to share this work! We engineered a heme enzyme to activate diazirines, giving us access to donor-subsitituted carbe….
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Congratulations to Sam, @MicelleYoucelle, and Pengfei on their recent paper “Rules for Aza-Glycine Incorporation in Collagen Peptides” @ChemicalScience Also, we love Sam’s clever homage to The Price is Right in the outside cover art!
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Big congratulations to @danielwuhoo as he passed his dissertation defense and will be an alumnus from @PennChemistry! Dr. Daniel Wu will be joining @GSKUS as an Investigator in Chem Bio. We’re all excited for you and your future endeavors! 👏🙌
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Keep an eye out for some really cool probes made by our very own @ChrisJScience! 🧪🔥🔥🔥.
Hello! Rising third year @PennChemistry in the @DMChenowethLab here. I synthesize photoconvertible fluorescent molecules for spatiotemporal imaging and tracking of cells and cellular cargo. I’m an aspiring Chemical Biology P.I. and entrepreneur. #BlackinChem #BlackinChemRollCall
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Learn how to shine bright like a fluorophore designed by @JoomyungJun. Vicky’s 2nd pub after leaving @PennChemistry 😮.
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Your synthesis of that many azGly containing collagen peptides better be pretty good if you’re making that many! See our optimized SPPS methods (link here)
pubs.acs.org
Substitution of natural amino acids with their aza-amino acid counterparts in peptides has been a historically challenging prospect due to the diminished reactivity of the involved reagents. Current...
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~90 peptides if u include the sister paper (linked below). That’s a lot of reserved CD and HPLC time!
pubs.rsc.org
Herein, we report the systematic investigation of amino acid variation in the Yaa position of collagen peptides containing an adjacent azaGlycine residue. We demonstrate the reliability of azaGlycine...
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Rules for the Design of Aza-Glycine Stabilized Triple-Helical Collagen Peptides - A tour de force effort synthesizing ~46 peptides with 2 high res collagen xstal structures to complete the design rules for azGly incorporation by Sam Melton and colleagues
pubs.rsc.org
The stability of the triple-helical structure of collagen is modulated by a delicate balance of effects including polypeptide backbone geometry, a buried hydrogen bond network, dispersive interfacial...
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RT @jenheemstra: .@angew_chem the Chemistry field will remember how you handled this. You published a paper that literally had “diversity o….
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RT @ChristiansonLab: Congrats to group alumnus Yang Hai @yanghaiBioChem - our 2016 paper describing the crystal structure of HDAC6 was high….
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RT @ChemCommun: Have you read 'Rosetta custom score functions accurately predict ΔΔG of mutations at protein–protein interfaces using machi….
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