ChristiansonLaboratory
@ChristiansonLab
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Biological chemist and protein crystallographer; professor and former department chair @PennChemistry; Chesapeake Bay sailor, homeport Annapolis, Maryland.
Philadelphia, PA
Joined December 2017
After giving a lecture earlier today at the @UoMMIB in Manchester, UK, my hosts took me to the Midland Hotel, where in 1904 CS Rolls and FH Royce met to form the venerable Rolls Royce company! @rollsroycecars
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I had a delightful visit to @ITALFARMACO in Milan yesterday to discuss our mutual interests in HDACs. Their inhibitor Givinostat was recently approved for the treatment of Duchenne muscular dystrophy.
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Surprise! former grad student Dr. Sam Eaton and I re-refined the structure of the PDE3B-GSK4394835A complex [Rowley et al. (2024) J. Med. Chem. 67, 2049 (PDB 8SYC)], discovering that GSK4394835A is a reversible covalent inhibitor. See: https://t.co/tnqHpx3ooy
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Taking the water taxi from Back Creek to Annapolis City Dock to see the Sailboat Show!
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A new class of terpene synthases in giant viruses? Dr. Eli Wenger & I comment on this recent discovery at the interface of living and non-living systems [Park et al. (2025) Biochemistry 64, 3866]: A Giant Step for Terpene Biosynthesis | Biochemistry https://t.co/e1GwsOU5Gm
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Congrats to Dr. Matt Gaynes @MNG_Chem for successfully defending his PhD dissertation today – Welcome to the ancient and universal company of scholars!
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I walk past this bust of Nikola Tesla every day that I give my lectures at Penn – it is located in the lobby of the David Rittenhouse Laboratories, where lecture halls used mainly for science and engineering courses are also located. @elonmusk, does this look familiar?!
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Berkeley friends, if you're around Monday at 4pm please stop by at Nico's seminar to say hello!
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Congrats to grad student Matt Gaynes @MNG_Chem & undergrad @KristinOsika for showing us how avermitilol synthase manipulates trapped water to generate a highly strained sesquiterpene alcohol! Just out on bioRxiv: https://t.co/Ya7MSayg9n
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Very proud of my better half, recognized as a 2025 Woman of Impact in Tech! Looking forward to joining Anastasia at the Women Impact Tech conference next week in NYC.
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Congrats to @PennSAS senior @KristinOsika for her poster presentation in @PennChemistry! Her first-author PNAS paper & 2 more first-author follow-up studies are summarized. Kristin is applying to grad schools now– her research accomplishments already rival those of a PhD student!
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Congrats to grad student Matt Gaynes @MNG_Chem et al. for the 2.9 Å-resolution cryoEM structure of the 63-kD cyclase in a bifunctional class II terpene synthase, plus the discovery of substrate channeling between catalytic domains! Just out on bioRxiv: https://t.co/vvpLNFAT1t
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Today is #NationalIceCreamDay Natural antifreeze proteins purified have been used as a preservative in ice cream
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Congrats to @PennChemistry undergrad @KristinOsika and grad student Matt Gaynes @MNG_Chem for this fantastic study, showing how a class II terpene cyclase collaborates with a tailoring enzyme in bifunctional biosynthesis! Just out in @PNASnews: https://t.co/WCwYEy9URa
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Congrats to postdoc Eliott Wenger for his fabulous cryo-EM structure and enzymological studies of a massive bifunctional terpene synthase, variediene synthase, just out in @NatureComms! See: https://t.co/B45Pu3HgSj
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The chapel at Sidney Sussex College, Cambridge University. The head of Oliver Cromwell is buried here at a location known only to the Master, the Vice Master, and the Bursar. I was a Visiting Fellow here 19 years ago!
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Many thanks to Ben Luisi and colleagues for hosting my seminar visit to the Department of Biochemistry at Cambridge University today! We enjoyed a post-seminar feast at Little Petra, a splendid Jordanian restaurant.
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Excited to give this week’s seminar in the biochemistry department at Cambridge!
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