Nick Porter
@NJP_Chem
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Scientist at Codexis. Bringing enzymes to bear against modern challenges. Breakfast food aficionado. | All views are my own.
Joined April 2016
So glad to finally get to share this! My heart skipped a beat when we saw the density for the carbene. Massive thanks to @EmmaDanelius and @gonenlab for such great work in solving this structure and to @francesarnold for her support in evolving and pursuing these biocatalysts!
Excited to share the latest #MicroED #CryoEM study - collaboration w @francesarnold lab to determine the novel structure of a directed evolution enzyme. @EmmaDanelius started the reaction on the crystals and captured the metal carbene reactive intermediate https://t.co/Ec2QMOBZaF
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Out now in @J_A_C_S! Many thanks to @francesarnold and our collaborators Emma Danelius and @gonenlab. https://t.co/WuH5Tfjb6y
pubs.acs.org
Biocatalytic carbene transfer from diazo compounds is a versatile strategy in asymmetric synthesis. However, the limited pool of stable diazo compounds constrains the variety of accessible products....
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@francesarnold @gonenlab Thank you everyone for the kind words! This activity has been as surprising as it is exciting, so I'm happy to have finally gotten to share it.
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Thrilled to share this work! We engineered a heme enzyme to activate diazirines, giving us access to donor-subsitituted carbenes in biocatalysis. Many thanks to @francesarnold and our collaborators Emma Danelius and @gonenlab. https://t.co/GTh2hCliUV
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Thankful for the privilege to work on these fascinating drug targets with so many prospects while working in the @ChristiansonLab!
Congratulations to former @PennChemistry grad student Nick Porter, currently a Helen Hay Whitney postdoc @francesarnold group, for his just-published #HDAC review in Curr. Op. Struct. Biol...a veritable exclamation point for his outstanding PhD studies! https://t.co/tAnQqchmoM
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Congratulations to everyone who worked on this paper! @NJP_Chem Thank you @BalabushkaFury for helping with the inside cover artwork design! @ChemicalScience
https://t.co/7Z4BnR9CUX “Aza-proline effectively mimics L-proline stereochemistry in triple helical collagen”
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Alright, now that I’m a stranger in a strange land, I have to start getting oriented and figuring out the basics. Most importantly, how am I going to watch the Game of Thrones premier tomorrow night?
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Mile 1,111: Made it to the Windy City in the Land of Lincoln. After sampling some deep dish pizza, I got back to the hotel room just in time to see my soon-to-be boss, @francesarnold, on The Big Bang Theory!
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