Yang Hai
@yanghaiBioChem
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Assistant professor @UCSB_Chemistry, Structural Biochemistry, Biosynthesis and Biocatalysis
Santa Barbara
Joined December 2016
Here’s our latest biosynthetic study on swainsonine, — a pathway far more complex than expected and packed with enzymes brimming with synthetic potential. Led by our fantastic postdoc, @shaonan_liu, who will soon be starting his own lab in Shenzhen!.
nature.com
Nature Chemical Biology - Swainsonine is a potent α-d-mannosidase inhibitor, but its biosynthesis remains poorly understood. Here the authors reveal an intriguing epimerization mechanism...
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Glad to share our recent discovery on the biosynthesis of trichothecene natural products. @J_A_C_S. This work is led by the amazing postdoc Jinmin Gao and it is a fun collaboration with Bob Proctor and Susan McCormick @USDA_ARS.
pubs.acs.org
Trichothecenes are a widespread family of sesquiterpenoid toxins that can pose significant risks to food and feed safety as well as environmental health. A defining feature of all trichothecenes is...
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RT @J_A_C_S: Biosynthesis of the Central Tricyclic Skeleton of Trichothecene Mycotoxins | Journal of the American Chemical Society @UCSB @u….
pubs.acs.org
Trichothecenes are a widespread family of sesquiterpenoid toxins that can pose significant risks to food and feed safety as well as environmental health. A defining feature of all trichothecenes is...
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A Manic Monday? We are excited to bring you the first PLP enzyme catalyzing intermolecular Mannich reaction @J_A_C_S This work is led by the amazing postdoc @shaonan_liu and supported by @ACSGCI.
pubs.acs.org
α,β-Diamino acids are important structural motifs and building blocks for numerous bioactive natural products, peptidomimetics, and pharmaceuticals, yet efficient asymmetric synthesis to access these...
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RT @angew_chem: Molecular and Structural Basis for Cgamma-C Bond Formation by PLP-Dependent Enzyme Fub7 (Yang Hai and co-workers) https://t….
onlinelibrary.wiley.com
Fub7, a pyridoxal 5’-phosphate (PLP)-dependent enzyme, catalyzes stereoselective and substrate-dependent regioselective Cγ−C bond formations. Now a structural and enzymological study have elucidated...
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Very honoured to have our recent @ACSCatalysis paper on izidine chemoenzymatic synthesis highlighted in this month's @OPRD_ACS "Items of Interest!".
Items of interest here . John Knight and team get you caught up on what is new and exciting in process chemistry. Only in @OPRD_ACS
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Shout out to our amazing postdoc @shaonan_liu who single-handedly pulled this off. @ucsbchemistry.
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Happy Holiday! .Check out our recent work on developing a chemoenzymatic platform for gram-level synthesis of amino-izidine motifs.
pubs.acs.org
Izidines are widespread structural motifs among alkaloid natural products and are also important building blocks commonly found in pharmaceuticals. Here, we report a concise and scalable chemoenzym...
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Congrats to postdoc Jinmin Gao and @ucsbchemistry undergrad alumnus Chen Zhou who led this study.
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Happy to see this work finally published. We have shown that LolT is a remarkable enzyme that can activate almost all types of amino acids.
Stereoselective Biocatalytic α-Deuteration of L-Amino Acids by a Pyridoxal 5'-Phosphate-Dependent Mannich Cyclase (Y. Hai et al.) @ucsbchemistry
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A fun collaboration with @yike_zou and a big shout-out to Jinmin and @shaonan_liu for leading this project, and fantastic undergrads @ucsbchemistry Chen and Darwin for their hard work.
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Check out our work on the discovery of a PLP-dependent cyclase from the loline alkaloid biosynthetic pathway
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RT @fryania: Interested in a post-doctoral opportunity in our #proteinengineering group and working on expanding our #biocatalysis toolbox….
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Very nice work from the Chooi lab on solving this long-standing puzzle.
Victorin's secret unveiled: Our latest work @SMS_UWA @UWAresearch published in @PNASNews in collaboration with @Turgeon @Cornell, @petersolomon99 @McdonaldMeganc @BiologyANU, solved a 70-year old oat disease mystery (1/5).
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RT @YitHengChooi: Victorin's secret unveiled: Our latest work @SMS_UWA @UWAresearch published in @PNASNews in collaboration with @Turgeon @….
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Looking for a postdoc fellow to join us working on biosynthesis and biocatalysis, or structural biochemistry! Please email me for details!.
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Very excited to officially start as an Assistant Professor @UCSB_chemistry! I will be always grateful to many people, especially @ChristiansonLab and @yitang_ucla for their support and mentorship.
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Sent out a dry ice package to UK on Monday by @FedEx @FedExEurope international priority. The package was not delivered until today. No wonder all the samples melted. #frustrated #Shipping @FedExHelp.
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