Christophe Heinrich
@ChristopheHein2
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Our study “Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of Mesial Temporal Lobe Epilepsy" is out @CellStemCell!.Fantastic work by Célia Lentini & @MariedOrange1.Great collab w/ BerningerLab @NicoMarichal👇.
www.cell.com
Mesial temporal lobe epilepsy belongs to treatment-refractory forms of human epilepsy. Lentini et al. show that reactive glia proliferating in the epileptic hippocampus can be reprogrammed into...
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Very nice study showing in vivo reprogramming of cortical astrocytes into fast spiking interneurons !.
Our paper on glia-to-neuron conversion is out in @ScienceAdvances. We generated neurons with the capacity of true high-frequency action potential firing and expressing parvalbumin from early cortical astrocytes in vivo💥👇🏻🧵
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Great opportunity in the field of liver disease ! 👏 In the beautiful city of Lyon in France! 👇Please RT.
The Lyon Hepatology Institute EVEREST is looking for a talented, dynamic and motivated investigator to develop an ambitious project in liver pathobiology!
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RT @CellStemCell: Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy
www.cell.com
Bershteyn and colleagues developed a human GABAergic pallial-type interneuron cell therapy from pluripotent stem cells for the treatment of drug-resistant mesial temporal lobe epilepsy (MTLE)....
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RT @biorxiv_neursci: Reprogramming early cortical astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons b….
www.biorxiv.org
Cellular reprogramming of mammalian glia to an induced neuronal fate holds potential for restoring diseased brain circuits. While the proneural factor Ascl1 is widely used for neuronal reprogramming,...
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RT @CSHL: Neuroscientist Magdalena Göetz began the world’s first-ever conference for researchers studying cellular reprogramming, different….
www.cshl.edu
Almost 20 years ago, neuroscientist Magdalena Götz attempted the impossible: creating brand-new neurons in the brain. The mouse brain to be exact. Her approach? She’d convert brain cells known as...
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First meeting ever on #CellStateConversions @cshlmeetings ! Fantastic meeting: great science and location👋Exciting discussions and truly stimulating !
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We are recruiting! .Interested in glia-to-neuron reprogramming as a novel cell-based strategy for brain repair? .We are looking for a talented postdoc to join our team and decipher the molecular mechanisms underlying lineage reprogramming👇.PleaseRT!
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Great news that induced GABAergic interneurons can reduce seizures in drug-resistant MTLE patients !.
The data released from Neurona Therapeutics on the first #epilepsy patient transplanted with interneurons is quite extraordinary! I see this as the first real evidence of clinical efficacy from a pluripotent cell therapy targeting the CNS
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Our last paper on the characterization of neuronal networks underlying absence seizures is finally out in Brain👇 Great work from Florian Studer and very fruitful collaboration with @DepaulisAntoine lab @GINeuroGrenoble 🥳🥳.
Using a genetic model of absence epilepsy in the rat, Studer et al. show that increased structural connectivity of cortical neurons contributes to the increased neuronal synchronization associated with the generation of absence seizures.
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We are recruiting!!.Interested in glia-to-neuron reprogramming as novel cell-based strategy for brain repair? We are looking for a talented postdoc to join our team and decipher the molecular mechanisms underlying lineage reprogramming👇.Apply before July 31, 2022.PleaseRT!
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Looking forward to present our data in the famous Cajal Institute! Thanks for your kind invitation !.
Mañana a las 12:30h en la Sala Washington Buño del #InstitutoCajal seminario de Christophe Heinrich. Nos hablará de “Reprogramming reactive glial cells into GABAergic neurons: A new avenue for reducing epileptic seizures”. Sin aforo pero la mascarilla sigue siendo obligatoria.
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RT @NicoMarichal: Check our new preprint! We tested whether the proneural TF Ascl1 or a more neurogenic mutant variant Ascl1SA6 can induce….
www.biorxiv.org
The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neural progenitor fate, implicated both in neurogenesis and oligodendrogliogenesis. Ascl1 has been...
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RT @crewilson: Come and work in Lyon! . A Chair of Excellence position has been opened by Labex Cortex @MagCortex for an outstanding early-….
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Happy to announce that our team co-headed by @ORaineteau/@ChristopheHein2 has been awarded the ‘FRM Team’ label🍾🥳We are grateful for the 3-year support from @FRM_officiel to decipher the mechanisms underlying glia-to-neuron reprogramming. TA & postdoc positions available soon!.
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RT @neurodaniela: 8th of July don't miss the one-day pre-#FENS2022 workshop on cell reprogramming!. Speakers from 🇩🇪🇬🇧🇫🇷🇺🇸🇸🇪 include:.@moln….
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RT @bergami_lab: How is the mito-proteome of neural stem cells shaped? In our last work, @GulzarW13675960 found that a rewiring of the mito….
www.cell.com
Wani et al. identify a key role for the protease YME1L in reversibly shaping the mitochondrial proteome of neural stem and progenitor cells (NSPCs) between activity states. YME1L-mediated proteome...
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RT @SocNeuro_Tweets: Check out our 2021 Highlights 👀(abstracts in 🇫🇷& in🇬🇧) 👉 with special thanks to @letelliermath….
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We are recruiting!.Interested in glia-to-neuron reprogramming as novel cell-based strategy for brain repair? We are looking for a talented postdoc to join our team and decipher the molecular mechanisms underlying lineage reprogramming👇.PleaseRT!
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RT @LNBofficiel: ⏰ C'est parti pour les Journées de l'Avenir !. 🙏 Un seul objectif : faire avancer la recherche médicale. 🔁 1 RT = 1€ reve….
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