Cristian Coarfa
@CCoarfa
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Associate Professor, Bioinformatics, Dan L Duncan Cancer Center, Center for Precision Environmental Health, Baylor College of Medicine
Houston, Texas
Joined October 2019
Congratulations Dr Powell @hannpowell96 and to her dedicated mentor @Kaochar2 !
Our newly minted Dr. Powell!! @hannpowell96 It has been a true honor to be part of your journey and to watch you grow into the remarkable scientist you are today. Congratulations on this tremendous achievement! #ProudPI I am deeply grateful for our exceptional lab family, whose
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Winnie (Ngan Fung) Li et al. reveal how macrophages mount a defense against HuNoV by phagocytosing infected cells — check out our latest findings! 👇 https://t.co/XXZziGxhIP
@NganFungLi @bcmhouston @BCMFromtheLabs @CCoarfa @OrganoidDiva @sash_ramani
journals.asm.org
Human noroviruses (HuNoVs) are important human enteric pathogens that cause outbreaks and sporadic gastroenteritis in people of all ages. HuNoV-induced illness can become chronic and debilitating in...
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.@ARodCastro, @MJSeasock, @CCoarfa et al identified a protein, #Let7, that keeps #pulmonaryFibrosis in check. @bcmhouston @BCMDeptMedicine @NatureComms @BCMGradSchool
blogs.bcm.edu
The findings can provide opportunities for new drugs and interventions to prevent or slow the progression of this devastating disease.
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Tremendous progress @AlanWaich4 !
🌉 Wrapped up #ATS2025 in SF! Thrilled to present our research on spatially defined transcriptomic signatures in early ILD. Huge thanks to @ivanorosas & our @bcmhouston @BCMDeptMedicine @BCMFromtheLabs team for their support! @ATS_RCMB @atscommunity
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.@ARodCastro, @MJSeasock, @CCoarfa et al identified a protein, #Let7, that keeps #pulmonaryFibrosis in check. @bcmhouston @BCMDeptMedicine @NatureComms @BCMGradSchool
https://t.co/b9bIAfL789
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Great study @MJSeasock and @ARodCastro ! Grateful for the opportunity to contribute
(1/n) Our article is out in @NatureComms! We set out to examine the contribution of the Let-7 microRNA over alveolar type 2 (AT2) stem cell plasticity in genesis of pulmonary injury and fibrosis in work led by @MJSeasock and Shafiq in my lab. Paper: https://t.co/iqF9N5UNYg 👇
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This is an amazing paper from the groups of @anshulkundaje & Scott Boyd and an example of how AI can be used well in biology. Basically, they are able to predict disease status (e.g. lupus, Covid, HIV, influenza) from BCRseq and TCRseq. I think this has great implications.
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Today, in collaboration w/ colleagues at the Institute of Science and Technology Austria (ISTA), we report the first-ever method for using light microscopy to comprehensively map all the neurons & their connections in a block of mouse brain tissue. More → https://t.co/i8wWRgPidU
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Thank you @naliphd for this exciting collaboration on inflammasome activation in heart failure. This article, among many strengths, follows up very creatively and convincingly on cell-cell communication alterations inferred using scRNASeq data @BCMFromtheLabs
Better late than never — our paper revealing that fibroblast NLRP3 activation promotes atrial myopathy and diastolic dysfunction is now out in #JACC: Basic to Translational Science! https://t.co/wuTLLwS13h 🤝@CCoarfa @StanleyNattel #DobromirDobrev
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Impactful work with the @PavlosMsaouel lab, based on epigenomic and transcriptomic integration. We know that science is beautiful, and when editors pick our figures for cover it it further confirms it 🫶
👇The @CCR_AACR cover below is a #RenalMedullaryCarcinoma cell expressing MUC16 (CA-125) in green and actin red with overlapping regions in yellow. Photo taken by Menuka Karki #MsaouelLab and also featured in our art contest led by @ED_PhD_ Full article:
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Highly recommended!
Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on April 25. Talks will feature recent exciting computational and experimental advances and will be live-streamed at https://t.co/zG98gkckMU. Please RT/spread the word!
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Congratulations to our #GIresearch symposium poster contest winners! 🥇 Luqiong Wang, @bcmhouston 🥈 Lauren Lynch, Baylor College of Medicine 🥉 Sohini Banerjee, Baylor College of Medicine It was close competition! We're lucky to have so many scientists at our institutions 🤠
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CA-125 as a Biomarker in Renal Medullary Carcinoma: Integrated Molecular Profiling, Functional Characterization, and Prospective Clinical Validation out on Clinical Cancer Research https://t.co/3p7zVOyAMY This study explores potential biomarkers 🧬for early detection and
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Very grateful to see this study published, and also grateful for our collaboration with @PavlosMsaouel lab ! Next, an even deeper dive into the epigenetics of RMC
@OncHahn @andrewjohnsmd @ERPlimackMD @crisbergerot @NazliDizman @BradMcG04 @IamLinghua @rahulshethmd @MikeSerzanMD @kaydaustin @LabGenovese @OAlhalabiMD @perelli_luigi @DrJeffreyGraham @ChadTangMD @salvolarosa @TiansterZhang @d_shapiro1 @QingZhangLab @Daniel_J_George @priyaraomd @UroDocAsh @ChapinMD @drmehrarohit @LisaHenske @DrDanielHeng @ED_PhD_ @DanielFrigo @rovingatuscap @katy_beckermann 5/5 This study establishes CA-125 as a clinically relevant biomarker for RMC, enabling non-invasive disease monitoring. Future directions include exploring MUC16-targeted therapies, and combiningCA-125 with ctDNA for precision tracking. #endRMC #CancerBreakthroughs
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@OncHahn @andrewjohnsmd @ERPlimackMD @crisbergerot @NazliDizman @BradMcG04 @GGiannarini @mjmoussa_ @PauloBergerot @SGoswamiMDPhD @LabGenovese @OAlhalabiMD @ZiadBakouny @DrJeffreyGraham @ChadTangMD @salvolarosa @TiansterZhang @d_shapiro1 @QingZhangLab @DrDanielHeng @priyaraomd @UroDocAsh @ChapinMD @drmehrarohit @LisaHenske @ED_PhD_ @DanielFrigo @rovingatuscap @katy_beckermann @HindRafei 5/5 All figure data are available in the manuscript page & the scRNA sequencing at the GEO webpage: https://t.co/D9WYTasCSn Visualization and real-time interrogation will be made available in the coming months through our Single Cell Research Portal: https://t.co/tw08Q2685m
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Great stuff @AyeshaShafi_PhD 👏
Elevated CBP/p300 expression linked to poor outcomes in advanced #ProstateCancer. @AyeshaShafi_PhD @CPDR_Labs joins @AndreaMiyahira @PCFnews to discuss AR coactivators CBP/p300 in prostate cancer and research revealing that CBP/p300 expression increases as prostate cancer
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💯🙂↔️
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That’s an amazing mentor, highly recommend
Post doc openings in the lab! Seeking highly motivated individuals who love science! https://t.co/dBQgQVLx4F
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👇aficionados of rare and common #kidneycancer should strongly consider applying! #rarecancers #endRMC @d_shapiro1 @Dr_Liz_Ellis_MD @NazliDizman @mjmoussa_ @perelli_luigi @minaseconomides @KyleBlumMD @Aiims1742 @DocMattCampbell @ED_PhD_ @ChadTangMD @AlexSherryMD @ASeoMDPhD
We are excited to announce our collaboration with @AACR to support early-career researchers. Together, we are committed to the future of #kidneycancer research. Apply Now to the Scholars in Training Award— don’t miss this opportunity: https://t.co/9jKTFkOUsS
#AACRScholars
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1/5 Excited to activate this week our fourth clinical trial designed for #RenalMedullaryCarcinoma (RMC). It will also separately enroll patients with epithelioid sarcoma, another rare but deadly cancer defined by loss of the SMARCB1 tumor suppressor: https://t.co/5MH7IkrUPp
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