COA - Chromophobe and Oncocytic Tumor Alliance
@kidneycoa
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Austin, TX
Joined December 2022
🚨Match Alert! COA launched four new programs this year to empower chRCC patients. Your gift keeps them running and thanks to a generous match offer, every dollar up to the first $10,000 raised is MATCHED until midnight for Giving Tuesday! Donate: https://t.co/KKZUU1SaGc
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3/3 · Higher FSP1 levels correlate with poorer patient survival outcomes · Dual inhibition of FSP1 and the glutathione/GPX4 pathway demonstrates strong synergy
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2/3 We discuss their recent paper on FSP1 (Ferroptosis Suppressor Protein 1) in chromophobe renal cell carcinoma. 🔬Key findings from this research: · Chromophobe RCC shows the second-highest increase in FSP1 expression compared to normal kidney tissue among cancers in the TCGA
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1/3 Targeting FSP1 in Chromophobe RCC. We’re excited to share a new video featuring Dr. @SamerSalem18, who recently completed his postdoc in Dr. @LisaHenske’s lab at Brigham and Women's Hospital discussing FSP1. Watch the full discussion:
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Incredible representation for chRCC at #IKCSNA25 including a phenomenal oral abstract presented by Sahil D. Doshi, MD summarizing the largest multi-institutional analysis to date on outcomes of metastatic chromophobe RCC with and without sarcomatoid features!
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More TRIP13 insights seen at #IKCSNA25 in a poster presented by Nathan Maulding, investigating Prognostic Signatures Associated with TP53 mutations in chromophobe RCC.
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Learn more about the exploration of TRIP13 in chRCC from Dr. Niki Zacharias Millward, KCA Trailblazer Awardee here:
kidneycancer.org
Dr. Niki Zacharias Millward received a 2025 KCA Trailblazer Award for research on "Interrogating the Role of TRIP13 in Sarcomatoid Chromophobe Renal Cell
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Thrilled to see @Dr_Liz_Ellis_MD presenting new research on TRIP13 in chromophobe RCC at #IKCSNA25 👏 @Dr_Liz_Ellis_MD received the COA/KCA 2024 Chromophobe RCC Focus Grant which helped identify TRIP13 expression in a chRCC cell line. @KidneyCancer
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Chromophobe RCC shows specific dependency on BCL-XL for survival. New research from the Henske lab and @adrenadine99 demonstrates that dual targeting of BCL-XL + MCL-1 induces significant cell death and synergizes w/ferroptosis Learn more here https://t.co/dqVQuTqNg2
@LisaHenske
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Scholar-in-Training Awards NOW OPEN! Award categories for kidney cancer include: 🌟Chromophobe (1) 🌟 RMC (1) Translocation or pediatric kidney cancers (1) VHL (1) International (1) Broad-category kidney cancer awards (any type) (5-6) Apply here: https://t.co/5Gq4xWbmIc
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Today is the first-ever Chromophobe Kidney Cancer Day! We’re shining a light on a rare kidney cancer subtype and the powerful community behind it. 🧡 Share your story 🧡 Celebrate survivorship 🧡 Raise awareness Tag us and use #ChromophobeDay so we can lift your voice.
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What if your takeout could change lives? Tomorrow, grabbing a meal from Panda Express helps fuel research and support those living with chromophobe kidney cancer. Order here and use code 9005619 at checkout. https://t.co/qils2LJTuL
#ChromophobeRCC #PandaExpress #DoGoodEatGood
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The Henske Lab making our day with this photo! So grateful to see them sharing Chromophobe Kidney Cancer Day (Sept 5th) during their lab meeting and their planned lab lunch from Panda Express. Keep sharing and tagging us in your plans- it makes our day, and lifts the community!
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Very excited to share our recent publication in @cgtnature 🎉 We found a targetable dependency on BCL-xL in Chromophobe renal cell carcinoma, offering new therapeutic opportunities Check it here 👉 https://t.co/kh9Luxsqdk
@LisaHenske #kidneycancer #ChromophobeRCC
nature.com
Cancer Gene Therapy - BCL-xL dependency in chromophobe renal cell carcinoma
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New paper on chromophobe kidney cancer discussing BCL-XL dependency in chRCC. "The BCL-xL-specific PROTAC DT2216, currently in clinical trials, may provide an opportunity for ChRCC therapy." https://t.co/jIFkqjrZT0
#kidneycancer #chromophobeRCC #chromophobe
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Save the code and the event to your google calendar here
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We've teamed up with Panda Express for Chromophobe Kidney Cancer Day! When you eat at Panda Express on September 5th you support chromophobe kidney cancer research and patient support programs. Mark your calendar for Sept. 5, 2025, save the code and join us in making a difference
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🗓️ Something big is coming. This September, we’re launching a first-of-its-kind day just for the chromophobe kidney cancer community. More soon. #chromophobeday
#kidneycancer #chRCC #chromophobe
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Possibly the most ironic part of this entire thread is the fact that exactly 4 years ago today I received my pathology report from surgery confirming I didn’t have chromophobe RCC but instead, a metastatic oncocytoma. Still been advocating for this community every day since 🧡
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