Our @NatureNano paper is out! 📄 https://t.co/huf1VQJiLj We built a programmable mRNA 🧬 platform that can be customized to induce tumor-selective immunogenic cell death with minimal toxicity, turning cold tumors hot and sensitizing them to immunotherapy. 🎯@UofTNews @UHN

How can generative AI and Robotics help advance drug discovery？ 🚀 Excited to introduce LUMI-lab! A foundation model-driven Self-Driving Lab (SDL) for autonomous ionizable lipid discovery in mRNA delivery 🤖🔍 🔬 What is LUMI-lab? LUMI-lab integrates molecular foundation

Whenever work feels overwhelming, reading a sweet comment from a student on a course evaluation instantly brightens my day. 😇

Thank you for supporting our research! @OHRareDisease

Excited to share that our lab has been awarded an R01 grant to develop pulmonary gene editing systems. Thanks @NIH for funding our work @UofTPharmacy @UofT @UHN_Research. We have multiple postdoc positions open. Interested candidates can email me at bw.li@utoronto.ca

Our 1st-gen AI-guided LNP engineering platform (AGILE) for mRNA delivery is online @NatureComms now. The 2nd-gen platform will come out soon. Stay tuned! @UofTPharmacy @UofT_TCAIREM @UofTPRiME @UHN_Research @PMResearch_UHN @UofT

@BowenLi_Lab and I are hosting this exciting panel on Tuesday to talk about the future of mRNA therapeutics- join us for what will surely be an invigorating conversation with these rockstars 😀

Key Highlights (3/3) - We identified a lipid, 119-23, which notably outperformed benchmarks in transfecting muscle and immune cells across several tissues. Thanks for the support of my colleagues at Anderson and Langer labs @kochinstitute and Li lab @UofTPharmacy

Key Highlights (2/3) - The ML models then help predict top candidates from a vast virtual library, significantly speeding up the discovery process compared to traditional methods.

Key Highlights (1/3) - We developed a diverse library of 584 ionizable lipids using a four-component reaction platform. - Our approach rapidly screens these lipids for mRNA transfection potencies, providing data that powers the training of machine learning models.

Excited to share our latest research published in @NatureMaterials https://t.co/qkk3bqR9PS It showcases an innovative approach combining machine learning with advanced combinatorial chemistry to enhance the discovery of ionizable lipids that are crucial for mRNA delivery.

Thrilled to be appointed as the GSK Chair in Pharmaceutics & Drug Delivery! Congratulations to @DrATaddio on becoming the inaugural GSK Chair in Vaccine Education & Practice-Oriented Tools. Exciting times ahead! #mrna #pharmacy

Free access to the paper:

Glad to share our latest work https://t.co/c56qURKut5 led by PhD student Jingan Chen and PDF Yue Xu on a new LNP that enables muscle-specific mRNA delivery with minimized off-target effects! They show that high immune cell transfection isn’t the only key to all mRNA vaccines!

Thanks for featuring our work on the cover! @NatureBiotech

There's a clear path to improving Covid mRNA vaccines with respect to potency, durability and safety, T-cell response, and intranasal delivery. But it's not getting done. https://t.co/c9dIvjgUOu @NatureBME @ragoninstitute @langer_lab

@natBME @AllenYJiang @kochinstitute @MIT Heartfelt thanks to my postdoc mentors Dan Anderson & Bob Langer for their unwavering support.🫂 Grateful for the generous funding from @NIH, @CIHR_IRSC, @NSERC_CRSNG, @UofTPharmacy, @PMResearch_UHN and @UofTPRiME, which made our research possible!😉

Thrilled to share our latest work in @natBME! We've developed a multiply adjuvanted #mRNA vaccine platform, engineering both LNPs & RNA molecules to achieve enhanced immune responses https://t.co/ANFkwoujxh Big shoutout to my colleagues @AllenYJiang & Idris @kochinstitute @MIT

Here is the active link -

🚀 Introducing AGILE: the game-changing platform for tailored mRNA delivery! Combining deep learning & automated combinatorial lipid synthesis, we've conquered boundaries and unlocked limitless possibilities of mRNA. Check out our latest work: