Larissa Di
@larissadi2
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Structural Biology and Protein Biochemistry - PhD in Structural Biology at @UniofOxford 🇬🇧. All views are my own.
United Kingdom
Joined January 2019
RT @ParasiteMatt: We have a place available on our Wellcome Cellular Structural Biology program for 2023 entry and are accepting applicatio….
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Thank you to everyone involved! @CaraEllison8, Carlos Riechmann, @CKeithCassidy, @danfelf, @adanpinto, @BenediktKessler, @Elliott_Lab_Ox, @BiochemOxford, @DunnSchCOSMIC. (7/7).
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Our structural and biochemical work provides the framework for future BIRC6 studies to further illuminate its multitude of functions. (6/7).
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Finally, we show SMAC binds to BIRC6 via multi-site mechanisms, resulting in incredibly tight binding. This enables SMAC to competitively displace caspases and antagonise BIRC6 anti-caspase function. (5/7)
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We reveal BIRC6 regulates cell death by ubiquitinating caspases-3, -7 and -9 and directly restricts caspases-3 and -7. Showing for the first time the direct inhibition of caspases by BIRC6. (4/7)
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Using in vitro biochemical assays, we show BIRC6 is an unusual E2/E3 hybrid ligase working exclusively with the non-canonical E1 enzyme UBA6 to ubiquitinate its substrates, including its regulator SMAC: (3/7)
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Our cryo-EM structures of BIRC6 alone and in complex with SMAC reveal BIRC6 is an anti-parallel dimer and surprisingly looks like a crab! The flexible N-terminal substrate-binding modules act as claws guiding potential substrates toward a central mouth-like cavity. 🦀 (2/7).
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Excited to share our most recent work on the giant ubiquitin ligase #BIRC6 out now in @ScienceMagazine . Thread below 🧵 (1/7)
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Congrats also to the @clausen_lab and @fischerlab1, it’s great to see all three papers out in @ScienceMagazine.
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Very excited to see our work on BIRC6 online!.
Delighted to share our latest structural & biochemical work uncovering how the gigantic #ubiquitin ligase, BIRC6, regulates cell death - out now in @ScienceMagazine! @BiochemOxford @larissadi2 @CaraEllison8 @adanpinto @BenedicktKessler.
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RT @Elliott_Lab_Ox: Delighted to share our latest work where we reveal how a gigantic ubiquitin ligase prevents cell death and is itself in….
biorxiv.org
Apoptosis, a form of genetically programmed cell death, can be triggered by either internal or external signals ultimately activating caspases, a family of proteases[1][1]. Certain members of the...
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RT @CrollTristan: I'm happy to announce that ISOLDE 1.3 is now released! To use, get your hands on ChimeraX 1.3 (release candidate 2021/12/….
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RT @anthony_berndt: I've learned that regardless of what molecular biology lab you're in, you're never more than 3 feet away from a stray s….
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💯.
Latest experiment failed, now friendship with science has ended.
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RT @ParasiteMatt: Another exciting moment for our cryoEM facility. The FIB-SEM arrives! Look how happy @TBharat_lab looks!! .
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Really insightful talk on (LGBTQI+) inclusion on STEM 👩🏻🔬.
Come join us tonight at 17:30 for a discussion led by @ClaraMBarker on the challenges and achievements of LGBTQI+ inclusion in Science, Technology, Engineering, and Mathematics (STEM) fields. Read more:
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RT @ActonLab: Peers support peers. "supporting colleagues who struggle with their mental health is a common occurrence in academic settings….
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RT @UniofOxford: We’re partnering with @AstraZeneca to ensure that our #COVID19 vaccine, if successful, can be manufactured & distributed t….
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RT @UniofOxford: Some of our @OxUniStudents came together to create #StudentsAgainstCorona - a platform that can be used to connect those w….
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