BauschLab
@BauschLab
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We study membrane and microtubules fluctuations using flickering spectroscopy, simulations and theory. The main message: the MTs push on the membrane and deform it, but are deflected by this soft boundary and hence "transport" the deformations along the membrane creating "waves"
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New preprint 🔥 my PhD swan song, with @BauschLab @hamfaizi @PVlahovska @HaganLab (+ Matt, Sarvesh Layne & Aparna) https://t.co/uVaq6sgNsq We put a microtubules+kinesin gel inside a GUV and... this happens: crazy fluctuations of a "cell" induced by a "minimal cytoskeleton"!
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The next speaker of our #Future3DAM Cluster Conference 2024 is Andreas Bausch from @TU_Muenchen. He will present recent results on Structure Formation in Organoid Systems, explaining why Activity Matters. Register now! https://t.co/CvdxBdndFA
#organoids #researchconference
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(1/3) How do cells squeeze their large nucleus through tight spaces? In work led by @JeremyKeys92 and in collaboration with @mingmingwu2 (now at @biorxivpreprint) we found that cells can push their nucleus by pressurizing their rear (video - left): https://t.co/oqh943RbBC
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Beyond spheroids! We show #PancreaticCancer cells self-organize into morphologically-faithful #organoids! Great work by Samuel, @arispapargyriou from @MaxReichert lab and @EdouardHannezo for a true collaboration between Biohysics and Medicine! https://t.co/qIGPJEBcbl
nature.com
Nature Communications - Pancreatic ductal adenocarcinomas (PDAC) exhibit complex morphologies challenging to capture in organoid models. Here, the authors develop PDAC organoids that can recreate...
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If you ever need an overview of measurement methods of network #mechanics, here's a suggestion 😎 (Fig. 3 in our review) #Teaching Including work by @BauschLab @SchmollerLab on how actin networks with alpha actinin form bundles and stiffen after repeated shearing.
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My first paper is out now. 🎉 We reconstitute the formation of VASP condensates on bilayers, which nucleate, polymerize and bundle actin filaments. The bundles grow by enhanced polymerization aligned to filaments. Thanks to @BleicherPhilip, @MarcoPayr and of course @Bauschlab.
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Ondrej’s article appeared today in PNAS. I hope you enjoy reading this updated version.
Make a dough and let it rise; observe it to self-organise. Don't forget to mention, though; it is an MT-actin dough. Our minds are very bright; we made a smart composite. We are writing history; the composite has memory. https://t.co/jcmeCiTtJT
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Happy to see this fun collaboration out! Scroll down for more on the dual encoding of patterning and mechanics by morphogens, to preserve patterns throughout complex 3d morphogenesis!
How are tissue patterning and mechanics coupled during complex 3D morphogenesis? 🤔Our new preprint by @diana__pinheiro shows that a morphogen gradient orchestrates pattern-preserving morphogenesis via motility-driven unjamming! Read here: https://t.co/193MYExk7H 🧵🔽1/n
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Very nice..! And reminding of gliding systems with steric constraints!
Spectacular discovery by @FrischknechtLab: #malaria #sporozoites form rotating vortices. Our theoretical analysis, now published in @NaturePhysics and led by @pintupatra05, identified the key physical aspects: self-propulsion, curved shape, chirality and mechanical flexibility
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New paper out in @NatureComms: polar patterns of filaments gliding *on a sphere*🌐 https://t.co/1U0kQJDo9M A project from my PhD I love, with co-first Chiao-Peng and our old student Alice. Here a [long!] thread, with a bit of backstory, results, discussion and...cool movies!🧵1/22
nature.com
Nature Communications - Active matter exhibits a range of collective behaviors offering insights into how complex patterns can emerge at different length scales. Here, Hsu et al. confine active...
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Good stuff
Check out this article! The authors discuss how the advent of #stem cell-derived in vitro analogs of the retina opens up an exploration of the interplay between #optics, electric signals, and #mechanics in a neuronal network! https://t.co/EzL3Zu0WHS
@LMU_Muenchen @SyNergy_Cluster
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Make a dough and let it rise; observe it to self-organise. Don't forget to mention, though; it is an MT-actin dough. Our minds are very bright; we made a smart composite. We are writing history; the composite has memory. https://t.co/jcmeCiTtJT
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Less than one week to submit an abstract! 👇
📢Announcing the second EMBL-IBEC conference on Engineering Multicellular Systems (9-11th Feb, 2022, Barcelona). Amazing list of speakers and unbeatable venue (YES, in person) 👇! Lots of room for contributed talks. Join us! @IBECBarcelona @EMBLBarcelona
https://t.co/gFgoxS8kDU
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🔥NEW PREPRINT🔥 How are collectively migrating cells constrained by the curvature & topology of 3D systems? We discovered a collective velocity wave propagating in such a system & show that it emerges as a response of active matter to curvature 👉 https://t.co/Dr700IsfY2
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🎉Glad to see this one published: Microtubules tune mechanosensitive cell responses https://t.co/qPwiYChDcF congrats to all authors and thanks @etiennemannevil and @shailajaseethar for the opportunity to image beautiful migrating astrocytes 🔬
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And they do rotate ! Collective cell motion drive the self organization of mammary gland organoids structures https://t.co/beWgwtjfR8
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