Barragan Lab
@BarraganLab
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The lab of Antonio Barragan. Interested in Toxoplasma gondii dissemination. (twitter run by PhD students in the lab).
Stockholm, Sweden
Joined October 2019
Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility ... https://t.co/lg1VtWwWF3
#biorxiv_micrbio
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Check out this curated collection showcasing the most cited and influential articles published in the @CellPressNews journal #TrendsinParasitology in 2022. #Review #Opinion #Forum #Spotlight #TrendsTalk #ParasiteoftheMonth
https://t.co/eI6PQsLRCq
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In this week’s Editors’ Choice piece, we highlight a study by Ten Hoeve, @HAKIMIMohamedA1, @BarraganLab, and colleagues in @cellhostmicrobe that shows how the parasite #Tgondii makes macrophages migrate. Read a summary in #ScienceSignaling: https://t.co/8PZqrL25iF
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Happy to share our latest work together with @HAKIMIMohamedA1 and @SaeijlabUCDavis labs on Toxoplasma dissemination @cellhostmicrobe
https://t.co/D1deMvLks1
cell.com
Toxoplasma gondii exploits the trafficking of phagocytes for dissemination. Ten Hoeve et al. show that parasitized macrophages acquire dendritic cell-like CCR7-dependent migratory properties via...
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We are very happy indeed that this work is out there now!
very proud of our latest work together with @BarraganLab and @SaeijlabUCDavis on how a #toxoplasma effector induces dendritic cell-like migration properties in infected macrophages https://t.co/eSsuyIRybg
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New Research: Toxoplasma effector-induced ICAM-1 expression by infected dendritic cells potentiates transmigration across polarised endothelium: The obligate intracellular parasite Toxoplasma gondii makes use of infected leukocytes for… https://t.co/cARd6uKE9s
#immunology
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we would like to say a very big thank you to Ildiko Dunay for a great discussion last week, as the opponent of our newly graduated Dr. Emily C Ross 🥳. A special thanks to the committee members as well!
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Congratulations to the new Dr. Arne ten Hoeve on a successful PhD defense! 🥳 A special thank you to Nicolas Blanchard for a very interesting discussion, and to all of the committee members.
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Drs @emily_c_ross Gabriela Olivera & Antonio Barragan review early passage of #Toxoplasma #gondii across the #blood–#brain #barrier #BBB. @Stockholm_Uni #Apicomplexa #Coccidia #CNS #Capillary #Permeability #Transendothelial #Migration #OpenAccess
https://t.co/Fq4UU0q1ro
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we're very excited to share our latest work! Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries
elifesciences.org
The invasion of Toxoplasma to the CNS across cortical capillaries is restricted by the integrity of the blood-brain barrier (BBB) and exacerbated by the inflammatory response.
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happy to share the latest work from Emily & Arne on integrin-dependent migratory switches in Toxoplasma infected DCs!
link.springer.com
Cellular and Molecular Life Sciences - Multiple cellular processes, such as immune responses and cancer cell metastasis, crucially depend on interconvertible migration modes. However, knowledge is...
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Happy to announce that our study GABAergic signaling in human and murine NK cells upon challenge with Toxoplasma gondii is now on https://t.co/Ccc9esqttK Thanks to our collaboration with @BarraganLab
biorxiv.org
Protective cytotoxic and proinflammatory cytokine responses by natural killer (NK) cells impact the outcome of infections by Toxoplasma gondii , a common parasite in humans and other vertebrates....
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we are excited to share with you our latest paper. thank you to everyone involved! A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites
elifesciences.org
Intracellular parasites hijack a conserved GABAergic system of immune cells to promote dissemination.
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A paper of Barragan Lab from Stockholm University in which I'm co-author is published in Journal of Cell Science. Congrats Einar Ólafsson!!!!!! @inv_uss @BarraganLab
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Excited to share our first preprint characterising how Toxoplasma manipulates host leukocyte cell migration.
biorxiv.org
Ras-Erk MAPK signaling controls many of the principal pathways involved in metazoan cell motility, drives metastasis of multiple cancer types and is targeted in chemotherapy. Yet, its putative roles...
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Congratulations to our newly graduated Dr. @einarolafsson! And a very big thank you to @FrickelLab for being a wonderful opponent, as well as all of the committee members.
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Einars thesis is out! (almost) time for champagne
Some light reading on Trojan horse mediated T. gondii dissemination
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"We have decoded how the parasite takes control of immune cells, converting them into moving "zombies" which spread the parasite in the body," says Professor Antonio Barragan. Find out how the cat parasite Toxoplasma gondii exploits immune cells to reach the human brain
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Sustained Egr-1 Response via p38 MAP Kinase Signaling Modulates Early Immune Responses of Dendritic Cells Parasitized by Toxoplasma gondii
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#Tgondii WIP gets DCs moving: @saeijlab use #CRISPR libraries to identify #Toxoplasma genes affecting in vivo fitness. They find that TgWIP is secreted into host cells & regulates actin dynamics to enhance transmigration of parasitized dendritic cells https://t.co/oDOFWjSu6R
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