Bai Lab PSU
@BaiLab_PSU
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Pioneering transcription factors and long-distance chrromosomal interactions @penn_state @PSUScience @BMB_PSU @PhysicsAtPSU (student-run account)
University Park, PA
Joined August 2021
The entire Bai lab attended @ASBMB Transcriptional Regulation. We were so excited to present posters and to hear Lucy give a talk!
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Our meeting on transcriptional regulation is underway! Next up: a session on #chromatin, genome architecture and remodelers. https://t.co/92RruQdlY5
#RNA #ASBMB
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Exciting news! đ @lab_poirier and @rcollepardo have curated an amazing @MGO_BPS program for the 2025 BPS Meeting! Featuring top speakers like @seresanu, @BaiLab_PSU, @McGintyLab, @AnnaPanchenko13, Shoji Takada, and Marcus Woodworth from @Melike_Lak. Donât miss it! đ⨠#BPS2025
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We are hiring! The Department of Biochemistry and Molecular Biology at Penn State âŚ@BMB_PSU⊠invites applicants for multiple tenure-track Assistant Professor positions in the broad areas of genetics, cell and developmental biology! Check us out!
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This work was led by bai lab students Cheng Xu (now a postdoc with @JefBoeke) and @hekleinschmidt (grad student @BMB_PSU).
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Out now in Molecular Cell! Along with Tan and Mahoney labs, we combine cellular, in vitro, and computational methods to understand how sequence features affect pioneer factor specificity (cofactors play a big role) https://t.co/HREadHzgCq
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Very proud of this highly collaborative paper with the @mahonylab @RemoRohs and Gordân labs in which we explore how ApiAP2 transcription factors with similar DNA binding specificities define their target genes, a ubiquitous challenge in all cells! https://t.co/owPNOPPBD7?
academic.oup.com
Abstract. Development of the malaria parasite, Plasmodium falciparum, is regulated by a limited number of sequence-specific transcription factors (TFs). Ho
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Check out our new Pioneer Factor review! We present both sides of the debate about whether pioneer factors have unique properties among TFs https://t.co/SDJcdhEBiM
tandfonline.com
Chromatin is densely packed with nucleosomes, which limits the accessibility of many chromatin-associated proteins. Pioneer factors (PFs) are usually viewed as a special group of sequence-specific ...
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Congratulations to the Bai lab's newest PhD Yi Li of @BMB_PSU! Yi's main thesis project was published today!
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Check out our latest paper in @NatureComms where we develop a methylation-based sequencing assay to capture chromosomal interactions with a viewpoint https://t.co/CxACUag7vc
nature.com
Nature Communications - Here, the authors present MTAC, a method to map chromosomal interactions in budding yeast. By applying MTAC to various viewpoints, they find that most of the long-distance...
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Bai lab PhD students James (@BMB_PSU) and Cheng (@huckinstitutes MCIBS) graduated yesterday! James has started as a biologist at @theNCI and Cheng is starting as a postdoc with @JefBoeke!
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Check out our latest work in @eLife! This work, led by graduate student James (graduating Sunday) uses a range of techniques, including a new methylation-based method to dissect gene cluster in haploid yeast. https://t.co/HhI6UB3R5Q
elifesciences.org
The condensates of activator Met4 are associated with 3D clustering of the MET regulon and its enhanced expression.
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Cheng's primary work is available currently as a preprint. Be on the lookout for more great work as Cheng transitions to a post doc very soon! https://t.co/gu1FpZTz9P
biorxiv.org
Despite the unique ability of pioneer transcription factors (PFs) to target nucleosomal sites in closed chromatin, they only bind a small fraction of their genomic motifs. The underlying mechanism of...
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Excited to share my postdoctoral work is now online @CellCellPress thanks to all the coauthors that contributed to this work!
Now online! Direct observation of a condensate effect on super-enhancer controlled gene bursting
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Congrats to the Bai lab's newest PhD! James passed his defense on Friday and is off to the NIH as a biologist!
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Preprint now available: we investigated the binding specificity of pioneer factor FoxA1 by developing a high throughput synthetic approach ChIP-ISO. https://t.co/gu1FpZU6Zn
biorxiv.org
Despite the unique ability of pioneer transcription factors (PFs) to target nucleosomal sites in closed chromatin, they only bind a small fraction of their genomic motifs. The underlying mechanism of...
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.@KellerCaponePhD's Genomics Research Incubator is an amazing and unique resource in the Center for Eukaryotic Gene Regulation at @huckinstitutes @penn_state. Want to perform regulatory genomics assays? Or are you developing a new sequencing assay? Cheryl is ready to assist.
Established under the leadership of Cheryl Keller, research professor of biochemistry and molecular biology, the Genomics Research Incubator is available to aid and enhance research and training at #PennState. https://t.co/vmuOpLmTjH
@KellerCaponePhD @huckinstitutes
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Katsuhiko Murakami, Ph.D., and Gene-Wei Li, Ph.D., are delving into the intricate genetics of cyanobacteria, a diverse group of microorganisms that play a crucial role in supporting healthy ecosystemsâfrom ocean depths to desert landscapes.
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Microbiology teaching faculty position at the Assistant or Associate Teaching Professor level is now open in the BMB Department at Penn State:
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