Arnab Ray Chaudhuri
@Arnab_RC1
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Associate Professor, Department of Molecular Genetics, Erasmus University Medical Center
Rotterdam, The Netherlands
Joined July 2019
Our PLAMseq paper is out today in @ScienceAdvances . We developed a TurboID-based protein-genomic approach to map proteins and protein interactions in the genome. Validated with CTCF and RNApolII. Applied to map Histone H1 SUMOylation genomic loci. https://t.co/7wDxkMLt2E
science.org
PLAMseq enables performance of genomics and proteomics of chromatin-associated proteins and protein interactions simultaneously.
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📰 #Actualidad| Los hallazgos sobre las proteínas implicadas en el proceso de recombinación homóloga abren vías para diseñar estrategias terapéuticas en tumores con mutación BRCA2 que hayan desarrollado quimiorresistencia @Arnab_RC1
https://t.co/qPEpJe51Cv
isanidad.com
Los hallazgos sobre proteínas implicadas en la RH abren vías para diseñar terapias en tumores BRCA2 que desarrollen quimiorresistencia.
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A tour de force by Raviprasad Kuthethur and amazing collaborations from Petr Cejka, Shyam Sharan and Krishna Mohan Poluri labs. Thanks a lot to Safa Nasrin, Satheesh Kumar Sengodan, Stefan Braunshier, Carmen Fonseca , Nupur Nagar, Ananya Acharya for putting it all together.
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We show that anti-recombinase FIGNL1 removes RAD51 in BRCA2 deficient cells causing homologous recombination defects and loss of FIGNL1 restores functional recombination in these cells. More on the mechanism in the manuscript.
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Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
science.org
Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase...
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The deadline for common entrance exam (JGEEBILS) for I-PhD and PhD is on 26th October. Please apply! @NCBS_Bangalore @TIFRScience
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JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. https://t.co/pNPOg1u3ZB Please repost!
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@Arnab_RC1 we are looking forward to your presentation at the #DRRSC26 🌟 Please share this with your followers to let them know the Early bird and Talk submission deadline is fast approaching - Tuesday 26th August 2025 ⏳ To register click here: 🔗 https://t.co/mdk4IfzYlK
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Happy to present our work in @embojournal where we show how p53 acts as a transcriptional repressor by directly recruiting DREAM complex in p21-independent manner. Congrats to @AgrawalRitu
https://t.co/8UXAvZPhnm.
@DBTIndia @FollowDbtNibmg @NImmunology
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Congratulations @SounakSahu, Mélissa Galloux, members of our BRCA Variant Analysis Unit @theNCI for this outstanding work. Sincere thanks to our collaborators Drs. Chari, Papaleo, Michailidou and their team members.
Excited to share our latest study in @Nature! We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! @ShyamKSharan @theNCI
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Excited to share the latest preprint from our lab Mitochondrial genome-encoded mitomiRs regulate cellular plasticity and susceptibility to ferroptosis in triple-negative breast cancer https://t.co/yq9l1DY53b
@MSLS_MAHE @serbonline @ICMRDELHI
biorxiv.org
Ferroptosis is a distinct form of regulated cell death promoted by iron-dependent lipid peroxidation. The metabolic plasticity of cancer cells determines their sensitivity to ferroptosis. Although...
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New paper with @KokicGoran and @SvejstrupLab in Cell Press! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by @dianavandenheu2 , @MartaRodrgzMart, Paula van der Meer! https://t.co/MofmQmpccW 1/6
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Excited that our work on transcription-coupled DNA repair is now published @CellCellPress! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸 ➡️ https://t.co/0SDr81nzhu
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🚨 New publication in @MolecularCell ! We reveal STK19 as essential transcription-coupled DNA repair factor, stabilizing the TC-NER complex and enabling efficient RNA Pol II ubiquitylation & TFIIH recruitment. ➡️ https://t.co/Rzzah46RMJ
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Our study show that maintaining a fine balance of RAD51 levels by positive and negative regulation is critical for efficient HR, maintenance of genome stability and cellular viability.
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This suggests that HR defects in BRCA2-deficient cells are primarily due to RAD51 removal by FIGNL1 rather than defective RAD51 loading. Furthermore, we identified the MMS22L-TONSL complex as responsible for loading RAD51 in BRCA2/FIGNL1 double-deficient cells.
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We demonstrate for the first time that defective RAD51 loading at DSBs and subsequent HR defects in BRCA2-deficient cells can be rescued by the loss of the anti-recombinase FIGNL1.
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What is the primary cause of homologous recombination deficiency observed upon loss of BRCA2? Is it due to the defect in RAD51 loading by BRCA2?
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A tour de force by @RaviprasadKV1 and tremendous collaborative efforts by @AnanyaAcharya, @Satheesh_NCI, @Little_Carm, and twitterless Nupur Nagar. Amazing collaboration with with labs of @ CejkaLab, @ShyamKSharan, @KMPoluri, @AmelieFT, Kannar and Lebbink labs.
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