The Lab of Adaptive Immunity and Homeostasis
@AndersenJT
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Jan Terje Andersen, professor
Oslo, Norway
Joined January 2018
Happy to share a new story on a versatile technology allowing design of long-acting #antibodies with tailored target-dependent mode of actions. @NatureComms @UniOslo_MED @novonordiskfond @forskningsradet @CoE_PRIMA
nature.com
Nature Communications - Antibody based biologics are a rapidly growing class of therapeutics with interest to enhance their performance, distribution, longevity and effectivity. Here, authors...
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#Boston next week! Reach out to talk science and opportunities. #albumin #IgG #antibodies @AutheraAS @UniOslo @Oslounivsykehus @CoE_PRIMA
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RT @CommsBio: Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formati….
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The C-terminal end of #albumin can be cleaved, which reduces binding to #FcRn. As such, the plasma half-life drops from 3 weeks to about only 3-4 days in humans. This biology may have implications for design of the next generation of human albumin based therapeutics. @UniOslo_MED
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In this review, we discuss the rise of #FcRn antagonists as a novel therapeutic class. @BioDrugsJournal .@UniOslo_MED @Oslounivsykehus
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RT @NEJM: FcRn protects IgG and albumin from catabolism, transports IgG across the placenta, and regulates IgG function. Blocking or augmen….
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RT @jbiolchem: New in JBC press: "Scientists' work describes an FcRn-driven mechanistic basis for induction of potent innate immune respons….
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RT @BioDrugsJournal: Torleif Tollefsrud Gjølberg and colleagues describe FcRn biology, and give an overview of the current clinical pipelin….
link.springer.com
BioDrugs - Autoimmune diseases are highly prevalent and affect people at all ages, women more often than men. The most prominent immunological manifestation is the production of antibodies directed...
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Talenter og reisen! Les om Simones vei fra Forskerlinja på Ullern vg skole til @unioslo@UniOslo_MED @Oslounivsykehus til CEO i @AutheraAS. @ShareLabOslo @OsloSciencePark @OsloScienceCity
skolesamarbeid.oslocancercluster.no
Simone Mester er administrerende direktør i bioteknologiselskapet Authera. I knivskarp internasjonal konkurranse med 800 andre kvinner fra hele EU, får hun som én av 40 kvinner, hele 75.000 euro i...
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Listen to Careers in Discovery where @TorleifGj , CSO and co-founder of @AutheraAS takes us through the company's journey from its academic beginnings @UniOslo_MED @UiO_LifeSci and @Oslounivsykehus
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We welcome Madicken Bildsten as a PhD student in our lab and @CoE_PRIMA🎈She will work on protein engineering strategies targeting cancer. Lab co-supervision by Nikoline Rasmussen and collaboration with the lab of @JOlweus 🔬@forskningsradet @UniOslo_MED @Oslounivsykehus
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RT @AndreasLaustsen: Thanks to Laura Tran from @TheScientistLLC for highlighting one of the recents scientific articles about #antibodies w….
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A warm welcome to our new lab member Lilli Bay! 🎈As a postdoc she will explore protein engineering strategies in the context of two favorite immune receptors; #FcRn and #TRIM21. Funded by @forskningsradet. @CoE_PRIMA @UniOslo_MED @OsloSciencePark @Oslounivsykehus
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Proud of @AutheraAS and @SimoneMester_ From master's degree to PhD to CEO in 2022. Simone is one of the winners of @womentecheurope! Thank you for the support. @forskningsradet.@OsloSciencePark
medwatch.no
I hard konkurranse med 800 søkere fra hele Europa har fire ledere av norske biotekselskap fått WomenTechEUs stipend på 75.000 euro.
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A seminar celebrating 🎈@DrRHatchett's honorary doctorate at @UniOslo_MED! @CEPIvaccines @CoE_PRIMA @Oslounivsykehus @Folkehelseinst @NFdep @Kunnskapsdep
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Last week was fun 🎈 Mark Cragg in Oslo as Visiting Professor of @CoE_PRIMA. Engaging talks and discussions on immunotherapy and how to engineer #antibodies for agonism. @unisouthampton @UniOslo_MED @forskningsradet @NSImmun
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On the cover of a magazine! 🎈Great collaboration with @AndreasLaustsen and the team🔬.
Cool to see our article "Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling" on the cover of @Structure_CP!.Read paper here:
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RT @AndreasLaustsen: Cool to see our article "Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies us….
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RT @AndreasLaustsen: Excited to share our new article “Engineering of #pH-dependent antigen binding properties for #toxin-targeting IgG1 #a….
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We heartily welcome Daniela Bejan as a PhD student to our lab & @CoE_PRIMA. She will work on innovative protein design strategies tailored to control a range of diseases. 🧫💊 Funded by @helsesorost @Oslounivsykehus @UniOslo_MED
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