Alex Goglia
@alexgoglia
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PGY5 @MSKCancerCenter, @MSK_RadOnc. Holman Research Pathway Resident in @RossLevineLab. MD/PhD from @RWJMS + @Princeton.
New York, NY
Joined March 2009
An intriguing study from @smherbrich & Pam Sharma @MDAndersonNews published in @Cancer_Cell TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors https://t.co/Cc25XDHbah Making lemonade out of CH lemons!
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Dr. Ross Levine (@rosslevinemd), Senior Vice President of Translational Research at MSK, has been named MSK's new Chief Scientific Officer (CSO). Dr. Levine will be responsible for setting and leading strategy for basic and translational research, including programs, centers,
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Launching the @ClevelandClinic CHIP Cardiology Clinic, an exciting step toward integrating clonal hematopoiesis into cardiovascular care. Excited to share my @CircAHA paper with Dr. Peter Libby, outlining our vision for the growth and development of CHIP Cardiology programs
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🦖 Something HUGE just hatched. Plasmidsaurus now offers RNA sequencing for gene expression analysis with: • As fast as 3 day turnaround • $50/sample for academia, $80 for industry • Up to ~10M unique transcript 3’ end reads per sample • Interactive results that let you
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Really excited to share our work identifying novel forms of clonal hematopoiesis across ~490K whole genomes at #ASHG25 ! Talking about this Thursday at 1:45pm, Room 210C . https://t.co/7mpwVB3WGv See many of our results here:
medrxiv.org
As humans age, we acquire somatic mutations in our blood, leading to clonal hematopoiesis (CH). Despite the prevalence of clonal hematopoiesis (CH) in aged individuals, recent searches for selective...
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This is not the usual phylogenetic tree of somatic mutations showing what clonal expansions are present and when they arose in a tissue. It additionally shows which cells within the tissue are affected and how the mutations change those cells. Congrats @landau_lab! Lovely work!
Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. https://t.co/pciw5yME0x
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Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! https://t.co/J5HekY1Pc0
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Seeing this in real time at VUMC where 1 in 5 cath lab patients have CHIP. We're building care pathways but standardization across centers would help. Curious what others are doing for longitudinal follow-up. @MichaelR21 @pnatarajanmd @AlexBickMDPhD
The authors advocate for the establishment of dedicated cardiovascular clinics to address the cardiovascular public health burden attributable to Clonal Hematopoiesis of Indeterminant Potential.
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Huge paper from Dan Landau! Such an exciting time for the somatic mutation field. Congrats Dan and team!
Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. https://t.co/pciw5yME0x
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T cells to the rescue (again)!! Congratulations to the winners! Quite frankly I would have added S. Rudensky…
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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This is pretty cool. TF's get in the way of DNA repair, increasing mutation rates at DNA regulatory elements. https://t.co/eG0HwT2WCC
cell.com
Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.
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Prospective phase II trial of short-course androgen deprivation, pelvic SBRT, and brachytherapy boost for NCCN high-risk #ProstateCancer with low-intermediate-risk #Decipher genomic score. Presented by @alexgoglia @MSKCancerCenter. #ASTRO25 written coverage by @zklaassen_md
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Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion https://t.co/MTeYS1AxjT
@Amitvermamds @SteidlUli
aacrjournals.org
Abstract. Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of...
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Couldn’t make it to ASTRO this year due to a conflict, but please go see @alexgoglia, @MSK_RadOnc Holman Resident PGY5, present our work today on outcomes for prostate spinal metastases treated with SBRT in CNS 3 from 12:45-2pm.
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Up next at #ASTRO25: MSK’s Dr. Alexander Goglia will discuss the impact of radiotherapy site, modality, and dose on subsequent clonal hematopoiesis. Follow along for coverage of the latest advances. @ASTRO_org Monday, 9/29 | 10:45 a.m. PDT Learn more: https://t.co/MViMCfKzkv
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Join the MSK Department of Radiation Oncology at their booth (#3306) during @ASTRO_org from September 27-October 1. #ASTRO25 #radiationoncology
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Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9
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Excited to share our latest study in @CELL @MDAndersonNews a new single cell DNA&RNA co-assay technology (wellDR-seq) used to study the interactions of DNA copy number and gene expression during breast cancer progression led by @KaileWang @RuiYejerry
https://t.co/99NxcuhzYN
cell.com
wellDR-seq allows single-cell whole-genome and transcriptome co-profiling at scale, enabling dissections of complex relationships between copy-number alterations and gene expression that inform our...
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Proton craniospinal irradiation significantly improves survival outcomes compared to involved-field radiotherapy for patients with leptomeningeal metastases from non–small cell lung cancer and breast cancer. https://t.co/NyLJEAGN5x
@JHGLab @DrBetofMDPhD
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🚨📢❗So proud and excited to share our latest work, "Clonal Hematopoiesis Dynamics and Evolutionary Fitness During Cancer Treatment Impact Clinical Outcomes", now available: https://t.co/EQu4Ilx2Hf🧵
medrxiv.org
Clonal hematopoiesis (CH) is the age-related expansion of mutated hematopoietic stem cells without other hematologic abnormalities. In patients with solid tumors, CH is associated with higher...
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