Suneet Agarwal Lab
@Agarwal_Lab
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We study bone marrow failure syndromes, telomere biology, and mitochondrial biology using patient derived induced pluripotent cells @BostonChildrens
Boston, MA
Joined September 2019
End of an era - last day for @wmannherz as a PhD student in the @Agarwal_Lab. Congratulations Will on your fantastic thesis work! Thanks for your tremendous contributions and collegiality in the lab. All the best back in med school, looking forward to many great things ahead!!
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Delighted to have worked with the incredible team led by @CalebLareau, @LeifLudwig. Thanks to patients and families @TheChampFound
I'm so grateful to have worked with a terrific team of co-authors. A special thanks to @LeifLudwig (and his new group!), the @Agarwal_Lab for enabling this work with precious patient samples, and supervision and support from @Satpathology, @bloodgenes, and Aviv Regev 🙏 2/22
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🎉 OUT TODAY @NatureGenet 📰 Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells 🧑🏿🤝🧑🏼 @CalebLareau @LeifLudwig @Agarwal_Lab and team ⬇️ https://t.co/GjX0rX3eqt
nature.com
Nature Genetics - Single-cell analyses of immune cells from patients with pathogenic, single large-scale mitochondrial DNA (mtDNA) deletions including Pearson syndrome describe heteroplasmy...
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Thank you so much @Bryan_Lab_CMRI !Honored for your comments on our work.
Happy to have been asked to comment on a really interesting finding by @Agarwal_Lab and @wmannherz. Telomere length control by thymidine - likely to have far-reaching implications. https://t.co/bw10HW5Vnv
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A true pleasure and honor to do this with @wmannherz ! Thank you for all your contributions, and very excited to see all that is ahead for you!
Huge thanks to @Agarwal_Lab who has been an amazing mentor since I joined the lab four years ago thinking about doing a telomere length CRISPR screen. This experience has been all I could have asked for from my PhD.
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Congrats to the incomparable @wmannherz on his phenomenal work! Adding/reiterating thanks to patients & families @teamtelomereinc, @NIDDKgov, @nih_NHLBI, very grateful to our reviewers incl @jenscs83 and @Bryan_Lab_CMRI, and editors @NatureGenet
Excited to share my work w/ @Agarwal_Lab identifying that thymidine nucleotide metabolism controls human #telomere length, now published @NatureGenet.
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Dr William Mannherz @BCHStemCell @Agarwal_Lab novel approach to #telomeropathies by #manipulating thymidine nucleotide metabolism #ASH22 @ASH_hematology
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Early detection and screening can be instrumental for cancer diagnosis and treatment. Katie Stevens, Executive Director of TT, and leaders from @RUNX1Research and @CureSDS met with @WhiteHouse to discuss improving early cancer detection and treatment outcomes for #CancerMoonshot
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So excited this book I've been co-editing is now available on Amazon or for PDF download!
We have been brimming with excitement to make this announcement: The Second Edition of the Telomere Biology Disorders: Diagnosis and Management Guidelines have officially been published! Learn more, download the guidelines, or request physical copies: https://t.co/K9UFPZ8Stb!
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A true labor of love of so many incredible individuals! The 2nd edition Telomere Biology Disorders: Diagnosis and Management Guidelines is out: https://t.co/Rdn5ry7ubf!
@JoyRH’s beautiful words say it best: More wins, fewer losses More smiles, less suffering More hope, less hurt
We have been brimming with excitement to make this announcement: The Second Edition of the Telomere Biology Disorders: Diagnosis and Management Guidelines have officially been published! Learn more, download the guidelines, or request physical copies: https://t.co/K9UFPZ8Stb!
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I'm excited to share the 2nd edition of the #Telomere Biology Disorders: Diagnosis & Management Guidelines! Patients, families, clinicians, and basic scientists collaborated from around the world collaborated to make this update possible #TeamScience #RareDisease
We have been brimming with excitement to make this announcement: The Second Edition of the Telomere Biology Disorders: Diagnosis and Management Guidelines have officially been published! Learn more, download the guidelines, or request physical copies: https://t.co/K9UFPZ8Stb!
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Very excited to see these finally published! An amazing resource complied from a range of experts in the #telomere community addressing all clinical aspects. Particular thanks to @SharonSavageMD @Agarwal_Lab and Katie Stevens for being the driving force. Free access below. #BMFsm
We have been brimming with excitement to make this announcement: The Second Edition of the Telomere Biology Disorders: Diagnosis and Management Guidelines have officially been published! Learn more, download the guidelines, or request physical copies: https://t.co/K9UFPZ8Stb!
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We have been brimming with excitement to make this announcement: The Second Edition of the Telomere Biology Disorders: Diagnosis and Management Guidelines have officially been published! Learn more, download the guidelines, or request physical copies: https://t.co/K9UFPZ8Stb!
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A review by Kirsten Brenner from our lab on the consequences of replication stress at telomeres and how DNA repair pathways acting at telomeres can contribute to genomic instability. This was ALL KIRSTEN and is a testament to her outstanding critical thinking and writing skills
Now online - a Review from Kirsten Brenner and @LabNandakumar titled "Consequences of #telomere replication failure: the other end-replication problem". #replicationstress #breakinducedreplication #BIR #mitoticDNAsynthesis #MiDAS #ALT
https://t.co/Dyod5pK1Vx
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Here's our newest paper, out today in @CellReports. This was born of our previous work of developmental determinants of leukemia lineage that got us interested in infant leukemia. https://t.co/GkK0gkZBcE
cell.com
Morris et al. use single-cell transcriptomics to identify a candidate-initiating cell in B-acute lymphoblastic leukemia (B-ALL) with rearrangement of the KMT2A/MLL1 locus (MLL-r), finding that this...
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Happy😊to share our work on human telomerase with shelterin protein TPP1 @Nature. Our cryo-EM structures define the determinants of telomerase recruitment by TPP1, TERT–TER interactions, and structural basis of telomerase inhibitor & telomeropathies.
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Celebrating amazing physician-scientists @Areejmd @DrChoueiri Suneet Agarwal @the_asci w @srviswanathan 🥂 Congratulations to all #asci2022 inductees🎉🍾!!
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HUGE thanks right back @TeamTelomereInc for letting us takeover today! We are tremendously grateful for your support and inspiration, which drives our work every day!!
We extend a HUGE thank you to @Agarwal_Lab for taking over our Twitter account this #TakeoverThursday! We are so grateful for the important work you all do, and we consider it an honor to support your research for those with #Telomere Biology Disorders.
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