Agard Lab
@AgardLab
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Structural Biology/Biochemistry Lab @UCSF #cryoEM Tweets by lab members
San Francisco, CA
Joined October 2020
Smriti Sangwan (@smriti_sangwan) from the @agardlab & Peter Walter labs @UCSF is about to present her research - molecular mechanisms of translational regulation.
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🎉🎉🎉
New featured image on our homepage! https://t.co/q0mdqcGp64 Related to this article: The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice https://t.co/8OpvsCkiFh
@ENieweglowska @AgardLab @UCSF
#phagenucleus #jumbophage #phage #structuralbiology
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Congratulations to Maru & team on the lab’s latest pub! PP5 requires the molecular chaperone Hsp90 to dephosphorylate CRaf kinase and Hsp90 cochaperone Cdc37. Here, authors show how Hsp90 acts as a platform to allow for targeted dephosphorylation by PP5. https://t.co/lNW7DwPMSk
nature.com
Nature Communications - PP5 requires the molecular chaperone Hsp90 to dephosphorylate CRaf kinase and the Hsp90 cochaperone Cdc37. Here, authors show how Hsp90 acts as a platform to allow for...
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Check out the latest preprint from @andreafossati9 and @MozumdarDeepto on using SEC-MS to identify protein:protein interactions during jumbo phage infections! Congrats, team! #phage #jumbophage #secms
New preprint alert! Here we show how SEC-MS is a powerful tool for host pathogen interactions profiling. We applied it to Jumbophages, which are large bacterial viruses (>300 genes) holding great potential as antibiotics. What did we find? 1\n https://t.co/qaQHKvkQtO
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Please check out our latest publication from grad student @ENieweglowska on the self-assembly of the phiPA3 phage nucleus! Congrats to the whole team! @MmendezMoran @minkbaek @UWproteindesign @yifan_ucsf @joeBondyDenomy
Excited to share the, now published, final version of my grad school research! Here are a few PhuN highlights from the full story. 🧵 #phage #jumbophage #cryoem
https://t.co/qzrLruvhzY
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Check out our latest preprint! #CryoEM structures of immunophilins, FKBP51 and FKBP52, in complex with Hsp90 and the glucocorticoid receptor, demonstrating the FKBP co-chaperones directly bind an Hsp90 client to regulate client activity. From recent grad @ChariMN w/ Jill Johnson
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor https://t.co/W4dyA22Ewt
#bioRxiv
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@AgardLab shared amazing data (published/unpublished) on Hsp90 chaperone complexes. @Hsp90Machine
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High resolution cellular cryoET!
We optmized in situ cryoET to achieve 6 A reconstructions of mouse sperm doublets! The unique tertiary structures allow de novo protein identification of novel sperm proteins by computationally searching in the AlphaFold2 library of entire mouse proteome!
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A family of novel immune systems targets early infection of nucleus-forming jumbo phages https://t.co/1u6lDWCcgI
#biorxiv_micrbio
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this just in --- our FTD CWOW website is LIVE! https://t.co/bVsOi0AjL9 Time to spread the news! Great work from our team @Karen_Shuster, @aimee_kao @YokoyamaLabUCSF @karchlab @AgardLab @metadsr_ @tauCWOW #ftdcwow
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We’re excited to announce that David Agard, Bridget Carragher + Clint Potter have joined our new @ChanZuckerberg Imaging Institute to bring together scientists and engineers to develop new cryoelectron microscopy imaging hardware and software 🧵 https://t.co/nQXlQe70ak
czimaginginstitute.org
Researchers at the Chan Zuckerberg Imaging Institute will develop revolutionary new imaging technologies.
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Congratulations, @MmendezMoran! #phdcandidate
I’ve passed my qualifying exam—a huge milestone on my way to a PhD! So lucky to have amazing mentors and lab mates doing incredible science and throwing even more incredible @AgardLab parties!
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Check out our latest pre-print from postdoc Zhen Chen @ZhenChentccz on mammalian sperm axonemes revealed by in situ cryoET!
Our preprint on asymmetric axonemes of mammalian sperm revealed by FIB-SEM/cryoET: https://t.co/hxlcSM72BG Thanks for the support from the Vale lab and Agard lab! This work would not be possible without my amazing collaborators from the Lishko lab and Janelia Research Campus.
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Explore emerging research and network with peers at our Protein Folding in the Cell Conference. Organized by Manajit Hayer-Hartl @MPI_Biochem and Jeffery Kelly @scrippsresearch. Don't miss keynote speaker David A. Agard @AgardLab
https://t.co/Jf0cxatSmF
#PFCSRC22
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The {varphi}PA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice https://t.co/41TLLnfeTo
#bioRxiv
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Congratulations to all of our authors! @ENieweglowska, Axel Brilot, @MmendezMoran, @minkbaek, Junrui Li, Claire Kokontis, David Baker (@UWproteindesign), @yifan_ucsf, and @joeBondyDenomy
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Check out our latest preprint showing that the major protein enclosing the Phage Nucleus (PhuN) forms a tetrameric lattice with C2 symmetry. The symmetry establishes 4 unique interfaces, two large enough to act as channels for small molecules, RNA, or even unfolded proteins.
Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice! https://t.co/nQwHJEjSNU
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We've got that Friday feeling! Earlier this week, #tau2022 was a success! Our #ftdcwow team was in attendance and thrilled to discuss about Tau. @karchlab @YokoyamaLabUCSF @AimeeKaoLab @AgardLab @metadsr_
alz.org
Leading experts from academia, industry, philanthropy and government will meet to address the future of tau research. Learn more and register.
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#CryoeM #CryoET has enormous potential allow researchers to study #structuralbiology in situ but low throughput limits applications. This new publication from Shawn Zheng of @AgardLab @UCSF addresses that problem and offers on-the-fly processing!
biorxiv.org
AreTomo, an abbreviation for Alignment and Reconstruction for Electron Tomography, is a GPU accelerated software package that fully automates motion-corrected marker-free tomographic alignment and...
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