Chih-Hang Wu
@AdamWu9527
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Associate Research Fellow at IPMB, Academia Sinica, Taiwan. Plant immunity, molecular plant-microbe interactions.
Taipei, Taiwan
Joined April 2014
I’m excited to share our latest preprint on the cell biology of plant hypersensitive cell death! 🌱💥.We used live-cell imaging to unravel what happens after resistosome activation—one of the least understood phases of plant immune responses.
biorxiv.org
Plant nucleotide-binding domain leucine-rich repeat-containing (NLR) proteins act as intracellular immune receptors that assemble into resistosomes to execute immune responses. However, the subcell...
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RT @MiaoYansong: 🚀 Our full website is now live — Registration is open, and short talk slots are available. Please….
ntu.edu.sg
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RT @ntusbs: Save the Date: Singapore Bioscience Symposium 2025. 📅 10–12 Dec 2025 |📍SBS, NTU Singapore.Spotlighting Plant Biomolecular Conde….
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RT @Yasu0407: 🎉 Our new paper is out in Science Advances!. Plants can detect parasitic nematodes. #PlantImmunity #….
science.org
Trehalase-derived peptides trigger LecRK-V-mediated plant immunity, potentially enabling broad detection of pathogenic organisms.
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RT @ShirasuLab: Our new work lead by Anuphon. Cryo Structure of CARD1 reveals copper in the ecodomain, required for sensing H202. The pheno….
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RT @AlbertoPMacho: Our latest article is now online!.@PlantBiotechJ . Expression of Arabidopsis FLS2 in N. benthamiana confers responsivene….
onlinelibrary.wiley.com
The association between Arabidopsis FLS2 and BAK1/SERK3 triggered by bacterial flagellin is the best-studied example of plant PRR receptor/co-receptor complex. Although most plants are able to...
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RT @SaskiaHogenhout: Aphid effectors suppress plant immunity via recruiting defense proteins to processing bodies | Science Advances https:….
science.org
Aphids hijack plant immunity via p-bodies, but plants fight back with a heat shock protein in an unexpected twist on defense.
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RT @JMadhuprakash: 🚨New @biorxivpreprint alert! .We are thrilled to share our latest findings—building on our earlier work on suppressors o….
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RT @erhminlai: #Agrobacterium-mediated transformation (AMT) is the key technology to advance research in #MPMI. Great to meet old friends a….
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RT @erhminlai: Great place to develop your independent career on #MPMI @IPMBSinica. We @AdamWu9527 @LaySunMa1 @KaWaiMa6 are here #2025ISMPM….
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Great to hear that the strain is useful for you. Thanks for sharing the excitement! @iHooghvorst.
@AdamWu9527 this new R. rizhogenes strain is pretty awesome for transient expression of ruby in tomato! . Excellent work that opens a lot of possibilities in our research, I appreciate.
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RT @mpcontreras4: Thrilled to share our latest @biorxivpreprint! This work started during my PhD and was finished together with @JMadhuprak….
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RT @HsiehYp: Exciting news! I am launching the Lab of Polymicrobial Interaction & Evolution @IPMBSinica @AcadSinica! 🎉 Our brand-new websit….
labofpie.org
We study the mechanisms of cross-kingdom microbial competition and how it influences microbial evolution and interaction with hosts
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RT @mpcontreras4: Here’s the major plot twist… AVRcap1b does not interact with resting-state NRCs but interacts specifically with the activ….
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RT @biorxiv_plants: An effector from the potato late blight pathogen bridges ENTH-domain protein TOL9a to an activated helper NLR to suppre….
biorxiv.org
Pathogens counteract central nodes of NLR immune receptor networks to suppress immunity. However, the mechanisms by which pathogens hijack helper NLR pathways are poorly understood. Here, we show...
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RT @TheSainsburyLab: The Plant Cell: A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nema….
tsl.ac.uk
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RT @YiFeng_eYFP: Excited to share that our preprint is out!. We’ll be at IS-MPMI presenting two posters on this project:. 💥7/14 – P-387: Ca….
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💡Our findings provide a spatiotemporally resolved cascade of events downstream of resistosome activation. This opens new windows into how immune receptors orchestrate cell death in plants.
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Finally, the nucleus shrinks and releases its contents into the cytoplasm. The hypersensitive cell death concludes with the collapse of the tonoplast and plasma membrane systems.
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Further breakdown included:.ER fragmentation into vesicle-like structures.Plasma membrane lost its integrity.Each step marking deeper progression into cell death.
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We also saw cytoskeletal collapse: Both microtubules and actin filaments rapidly depolymerized. This breakdown may facilitate structural disassembly during death execution.
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