Alberto Macho
@AlbertoPMacho
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Scientist studying Plant-Pathogen Interactions. Scuba diving. Hiking. Football. Photography. @albertopmacho.bsky.social
Shanghai, China
Joined November 2010
RT @CSIC: 📜 El #CSIC firma dos memorándums de entendimiento con la @CAS__Science . 🏛️ Ambas instituciones promoverán la cooperación científ….
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RT @IHSM_CSIC_UMA: 📋 New paper from our researchers Carmen Beuzón, Javier Ruiz-Albert, Nieves López-Pagán and José Rufián!. Published at @N….
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RT @Yasu0407: Proud to share our must-read preprint, where we unveil a novel MAMP-immune receptor pair and pioneer the design of synthetic….
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RT @GangYuPlant: We are glad to write a spotlight on this interesting work " Non-adapted bacterial infection suppre….
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RT @simonmaechling: Humans have been modifying crops for thousands of years. We shouldn’t fear genetic engineering. It is simply an exten….
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This way, RipE1 hijacks plant regulators of protein post-translational modifications to promote its stability and allow its virulence activities, showing what could be one more layer of the co-evolution between plants and pathogens. 5/5
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2- RipE1 associates with plant ubiquitin proteases, which contribute to the de-ubiquitination of RipE1 and promote their stability. 4/5
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In this work, we found that the stability of the Ralstonia effector RipE1 is promoted by 2 independent mechanisms:. 1- RipE1 is phosphorylated in plant cells. Lack of these phosphorylated residues results in a strong ubiquitination of RipE1, and a lower protein accumulation. 3/5
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Most Gram (-) bacterial pathogens inject effectors into host cells to promote disease. But, being foreign proteins (initially just delivered as polypeptides) that become a serious threat to the host. Why are they not degraded in plant cells?. 2/5.
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Our most recent work is online @PLOSPathogens . A bacterial type III effector hijacks plant ubiquitin proteases to evade degradation. By Wenjia Yu, Meng Li, et al. 1/5 👇🏼.
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RT @simonmaechling: Bad policies destroy nations. In 2021, Sri Lanka banned synthetic fertilizers and pesticides overnight - forcing the c….
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RT @Yasu0407: Excited to share our new publication on a novel MAMP peptide conserved across nematodes, insects, and fungal pathogens, along….
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🎉 10-year anniversary of our lab 🎉 . Big thanks to everyone who joined us over these years and made this lab such a nice place to work
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We also found that the auxin accumulation is promoted and required by bacterial infection to induce root hair formation, but not earlier xylem differentiation. Our results shed light on Ralstonia-induced root developmental alterations and their underlying mechanisms. 6/6
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In addition to the reported alterations, we observed an earlier xylem differentiation during Ralstonia infection. This is not dependent on PEP receptors, or BAK1, but requires pathogen effectors, suggesting an active promotion of vascular development upon root invasion. 5/6.
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In this work, we combined confocal imaging, fluorescent gene expression markers and pharmacological and genetic approaches to further characterize root developmental alterations caused by Ralstonia infection at the microscopic level . 4/6
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We have also recently shown that the Ralstonia effector RipAC contributes to a promotion of lateral root formation during Ralstonia infection, which seems to contribute to bacterial colonization and proliferation. 3/6.
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