Aaron R D’Souza
@AaronRDSouza1
Followers
122
Following
818
Media
11
Statuses
160
Senior Research Scientist @ SwiftDx
Cambridge
Joined July 2018
New cryo-EM data and an updated version of our pre-print with @SergeyVMelniko1. Our new aeRF1/Pelota-like ribosome hibernation factor, Balon, is delivered to the A-site by EF-Tu. It can protect both vacant AND translating ribosomes (P-site tRNA/mRNA) 🦠❄️ https://t.co/sZB7u79mXw
biorxiv.org
During starvation and stress, virtually all organisms arrest protein synthesis to conserve energy. Inactive ribosomes are converted into a dormant state, in which they are protected from damage by...
1
9
35
Today @PedroSiPinheiro etal. present in @natBME a library of base editors #MitoKO to ablate all protein-coding genes in mouse mtDNA. #MitoKO will help generating new, clinically meaningful models for mechanistic, drug discovery and pre-clinical studies https://t.co/DkMWEZth1w 1/8
4
56
131
You just can't keep vicars' daughters out of churches these days. Come and see funny people be funny about this funny old planet we live on.
Join comedians, scientists, thinkers and assorted nerds at Earth Showoff - Comedy Night under @lukejerram Gaia with @ScienceShowoff
@steve_x joined by @alexjenkin
@KatNilsson
@mackenwells @doctor_benji @annaraegeorge Thurs 27 October 7.15pm Tickets 👇 https://t.co/siGj3AKe5e
1
1
0
I'm recruiting a postdoc in structural/molecular biology to work on RNA, proteins, ribosomes and mechanisms of frameshifting in RNA viruses. Lots of exciting science, supportive new group, great facilities and fantastic city. Please retweet (and apply!) https://t.co/dBOpuoWkVJ
6
113
121
The @mito_oncogene lab @CRUK_BI is offering a permanent, senior research position - Associate Scientist. A great opportunity for someone looking to develop academic independence under some direction and develop their own ideas. Curious? Follow the 🧵👇
Hey Twitter - please RT 🙏- thanks to @ERC_Research, the Mitochondrial Oncogenetics Lab @CRUK_BI @UofGCancerSci is expanding! We’re looking for a permanent, senior member of the lab (Associate Scientist) to broaden and manage this expansion https://t.co/JLHamie8e6 1/4
0
15
9
OPEN POSITION in my lab. Info in the attachment. Please, contact Prof.Caterina Garone: caterina.garone@unibo.it
0
1
2
Hey Twitter - please RT 🙏- thanks to @ERC_Research, the Mitochondrial Oncogenetics Lab @CRUK_BI @UofGCancerSci is expanding! We’re looking for a permanent, senior member of the lab (Associate Scientist) to broaden and manage this expansion https://t.co/JLHamie8e6 1/4
4
67
78
There's still 10 days left to apply for a 3yr postdoc in my group 🥳 Molecular biology, biophysics and single-molecule imaging to study ribosomal frameshifting in RNA viruses🧬Great department, lovely city and lots of career support from me: https://t.co/1hqdfquog6
@BPSIYork
1
40
44
I'm hiring! 🥳 Looking for a postdoc AND a technician to work on translational recoding during virus infection. Biochemistry, cryo-EM, single-molecule imaging... please RT and get in touch if interested🙂 postdoc: https://t.co/4h7DbQfc42 technician: https://t.co/Gul6Dftdal
0
92
118
A BIG thank you to @ERC_Research for supporting my group @CRUK_BI @UofGCancerSci with an ERC Starting Grant! I’m humbled by the vote of confidence. For those interested in PhD or Postdoc positions aiming to unravel the mystery of #mtdna mutations in #cancer, watch this space… 😊
🎉ERC Starting Grant competition results are out! Over €619 million for the best ideas of young leading researchers - and the 1️⃣st set of grants awarded under 🇪🇺@HorizonEU. Find out who, where and why 👉 https://t.co/YvxqX1ev0r
#EUfunded #FrontierResearch #ERCStG
41
8
121
Last few days to apply for a fully-funded PhD with me, @LullaValeria and @mjplevin (deadline 7th January). Come and join us in beautiful York and work on mechanisms of IRES-mediated initiation in enteroviruses. Please RT🙂 https://t.co/lLo1PBhrmG
2
28
25
I've had a persistent cough for the last 3 days. If I do a lat flow with just the nasal swab as instructed, I get a negative. I've I do a throat swab as well, I get a positive. Has the virus just mutated to evade the nasal swab? Getting a PCR to confirm my hypothesis (n=1)
2
0
3
We have a vacancy for the position of research assistant. Come work with me! It's a lot of fun 🧬⚗🧪👩🔬👨🔬 #researchassistant #vacancy #sciencejobs
https://t.co/BJkMfYn6qY Message me if you need more info
0
0
0
Super excited to have my first publication out today in @ChemEngResDes. A mini review to whet your appetite for all the cool things possible with cell-free protein synthesis 🧪👩🔬👩💻 Thanks @ceronifranci @YuvalElani for the support 😎 https://t.co/eoJTGY5oV7
3
10
13
In this paper, we use in-gel SHAPE to study how the Gag protein changes the HIV-1 RNA. The RNA exists as a pool of different structures. We describe how the addition of the Gag protein shifts this pool towards a dimerization-competent structure, and then stabilises it. [3/3]
0
0
1
The HIV-1 RNA genome acts as both the template from which proteins can be produced and the genome that is packaged into the viral particle. This requires the RNA to change structure and dimerise. [2/3]
1
0
1
I’m very pleased to share this work that I completed while at the NUS, Singapore in the Kenyon and Lever lab. Thank you to all the people who were part of this work! https://t.co/7tYS54vs9d [1/3]
mdpi.com
HIV-1 packages two copies of its gRNA into virions via an interaction with the viral structural protein Gag. Both copies and their native RNA structure are essential for virion infectivity. The...
2
3
8
Just under 1 week to go - if you're interested to discover what mtDNA mutations are doing in the ~70% of cancers they pop up in, get in touch!
We’re looking for a postdoctoral scientist to join our team working on an exciting project looking at the role of mitochondrial DNA mutations in cancer. Please share/RT or get in touch with me directly for more info!
0
11
20