Immune system one pager

Here's a pic from Tim Ferriss 10th Anniversary fan meetup Newcastle, Australia @tferriss getting together in real life on @getriver_io

Vitamin B2 (Riboflavin) may be an effective treatment for sport-related concussions🧠 A daily intake of 400mg vitamin B2 led to an average recovery time of 10 days after concussion… …compared to an average of 22 days in the placebo group 👈 Contact sport athletes take note📝

A PCSK9-inhibitor (PCSK9i) is a medication that increase the number of docking stations (LDLRs) on the cell membrane being available for docking. This results in fewer Red Buses driving around and hence fewer passengers. Does this work?

Statins also lead to more docking stations, LDLRs being available. With more docking stations there are fewer LDL-buses driving around.

hence more LDL-buses driving around. Statins block the production of cholesterol in the liver cells (for the most part). The liver makes fewer passengers for the Red LDL-buses and there are fewer passengers in circulation.

an open docking station. The liver also makes a special guide for LDL and Lp(a) called PCSK9. The number of docking stations available (LDLRs) is regulated by a controller enzyme called PCSK9. The more PCSK9 there is, the lower the number of LDLRs and

Once the LDL-bus is attached to the LDLR, the whole complex is taken back inside the cell and dismantled. The dismantled part can be reassembled at a later stage. The Red LDL-buses get VIP-access to the docking stations, leaving the Red Lp(a)-buses driving around until there is

The liver is constantly making new LDLRs and dismantling old LDLRs. It makes new LDLRs inside the cell and when the cell receives the right signal it will move the LDLR from inside the cell to the outside of the membrane to be available as a docking station.

them back to the liver. The liver cells make docking stations on its cell membranes called LDL receptors (LDLRs) for Red LDL-buses to be docked and then be taken up inside for overnight parking. Hence taking LDL-buses out of the tunnels.

while others get an ApoA sticker and are called Lp(a). The Lp(a) bus drivers tend to be a bit reckless and bump into the walls of the tunnel (arteries) causing damage. The liver also makes big Blue Buses (lipoproteins) called HDL to collect tired passengers from cells and take

This new, full bus is called VLDL. The Red Buses leaves the liver and drives around in the tunnel (arteries) to deliver passengers to their destinations. As the passengers get off the big Red Bus, the bus gets smaller. Some Red Buses gets an ApoB sticker and are called LDLs,

I have attempted an analogy for #cholesterol and would love feedback. Would appreciate it if you have a spare second - maybe @OxPL_apoB or @PeterAttiaMD The liver makes big Red Buses (lipoproteins) to carry passengers to cells. The passengers are cholesterol and fat (TGs).

Great thread by @stevemagness Micromanaging our kids every experience and 'protecting' them from perceived dangers limits their capacity to problem solve & increase risk of mental health problems

In light of the grotesque attack on Israel by Hamas, I want to repost my conversation with reknowned Israeli historian Dr. Benny Morris. Already we are hearing apologists claim that Israel had this coming––that 75 years of colonial oppression is bound to result in an equal and

If a person with high Lp(a) of 219mnol/(88mg/dL) starts taking a PCSK9 inhibitor - will that person "feel" a difference? Given that person in already on a statin with cholesterol panel in range except high non-HDL @PeterAttiaMD @OxPL_apoB

Roger Waters is 80 today and we’re raising a glass to the great work we did together all those decades ago.

Just about to walk into Clean Health Live 2023. @cleanhealth @BioLayne is 1st up! Hope I get to meet him.

No change in diet, she was already consuming sufficient protein and calcium. No denosumab (Prolia) used. Started HRT She could not lift weights as a result of injury to forearm for 3 months and walked with a weight vest instead. It's never too late to start training @mackinprof