Jingzhou Zhang
@zhangjz07
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Pulmonary Critical Care Physician, Epidemiology/Genetics/Omics Lung Research @BUPulmonary
Boston, MA
Joined May 2017
grateful to receive the John W. Walsh Career Development grant from @AlphaFriend to support my research on genetic and proteomic risk prediction of lung disease in alpha-1 antitrypsin carriers. Many thanks to @mikecho95 George O’Connor @Awilsonlab @BUPulmonary for their support!
A1F proudly recognized the 2025 Grants Award recipients during the ATS International Conference. These innovative projects represent the next generation of progress in Alpha-1 research. Learn more about the researchers and their work:
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more evidence of the potential utility of polygenic risk scores in disease screening / case finding
Original Article: Assessment of a Polygenic Risk Score in Screening for Prostate Cancer (BARCODE1 study) https://t.co/unjcDVktiF Editorial: A Polygenic Risk Score in Practice https://t.co/xjmiEM9i0N
#Oncology
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Groundbreaking research has been published in Nature Genetics, offering new insights into the genetic mechanisms of Alpha-1. This milestone study advances the understanding of Alpha-1 and opens the door for future therapeutic developments. Read more:
alpha1.org
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency “This exciting study provides evidence of [...]Read More... from Nature Genetics:...
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Happy #ManuscriptMonday! Check out this freshly published paper from @zhangjz07 and team (including Dr. Victor Ortega and senior author @MattMollpulmccm - hint for an upcoming CP Webinar 👀) https://t.co/XtfEXGtSJq
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JAMA Editor in Chief Kirsten Bibbins-Domingo and Deputy Editor Christopher Muth give a summary of articles published from January 18-24. https://t.co/CKRmy7QvJ5
edhub.ama-assn.org
Editor’s Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief, and Christopher C. Muth, MD, Deputy Editor of JAMA, the Journal of the American Medical Association, for articles published...
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I’m excited to share this work hot off the press - genetic risk in case-finding for undiagnosed COPD. Grateful to my mentors @mikecho95 @MattMollpulmccm George O’Connor for the guidance! Many thanks to co-authors, @JAMA_current editors, and @BUPulmonary
A chronic obstructive pulmonary disease (COPD) polygenic risk score enhances the identification of undiagnosed COPD beyond a conventional case-finding approach in the general population. https://t.co/6BGxeyrtYG
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Happy to share our work using genetics and transcriptomics together for subtyping COPD patients. We found heterogeneity within high risk groups, showing a group with greater lung function decline and another more severe group. Many thanks @eBioMedicine
https://t.co/lyrCygjsuG
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April ERJ Podcast: @ProfJDChalmers & Ritesh Agarwal discuss revised International Society for Human & Animal Mycology ABPA working group clinical practice guidelines for diagnosing, classifying & treating allergic bronchopulmonary aspergillosis/mycoses: https://t.co/TOGXcLx9W5
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Early Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: The Costs and Benefits of Case Finding This paper reviews the clinical and economic evidence in favor of case finding for COPD 🔗 https://t.co/USNQLrxDy5
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Very excited and grateful to see our paper "genetically predicted BMI and COPD mortality" published in the AJRCCM. https://t.co/UJ8N2oIhPn Many many thanks to my mentors - Drs. George O'Connor and Michael Cho, collaborators, reviewers, and editors for the help with this work!
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🧬 We’re excited to announce that we have sequenced the whole genomes of 500,000 UK Biobank volunteers! 🧬 The dataset is the world’s largest of its kind and we’re proud to make it available to approved researchers around the world 🌍 https://t.co/m2EeGLTr1d
#500KGenomes
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Methodologic Issues Specific to Prediction Model Development and Evaluation Read the latest Special Feature in the November issue of @journal_CHEST: https://t.co/xmDeuUaS2t
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How are you raising awareness today for #WorldCOPDDay? How can we identify #COPD earlier to make more of an impact on disease burden? It's time to expand the horizon of COPD and recognize lung function is an integral part of overall health in all stages of life. For more
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I was incredibly honored to be part of this phenomenal event. Amazing science, mentorship, and friendship!
The future of respiratory disease research is HERE! #RDYIF2023 #PhysicianScientist #COPD #Asthma #MedEd #BreathingScienceIsLife
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The future of respiratory disease research is HERE! #RDYIF2023 #PhysicianScientist #COPD #Asthma #MedEd #BreathingScienceIsLife
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Some persons with a history of smoking and preserved lung function on spirometry have significant respiratory symptoms. They are often treated with COPD medications, but evidence for this approach is lacking. Research findings are summarized in a video. https://t.co/cSGeEf8o9m
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I'm excited to share our work on genetic risk and "early" COPD (COPD in young people) recently published @ERSpublications. Many thanks to @MattMollpulmccm, @BrianDHobbs and @mikecho95 for mentoring, and to all the coauthors!
A polygenic risk score is associated with earlier age of COPD diagnosis and is predictive for COPD occurring early in life, with clinical implications of individualised risk stratification and preventive measures https://t.co/SOWzHdRrbr
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Spirometry reference values for population aged 7–80 years in China #lung function #pulmonary
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