Yogesh Reddy
@yreddyhf
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HF doc at Mayo Clinic, interested in HFpEF, PAH, valve hemodynamics
Minnesota, USA
Joined July 2016
RT @HanCardiomd: Late-Breaking Clinical Trials to Watch at #ESCcongress 2025 : Global Health and reshaping cardiovascular care priorities….
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With inflammation being associated with HFpEF, MPO inhibitors are testing inflammation suppression in HFpEF. However with acute administration we saw acute worsening HFpEF hemodynamics in this RCT. Will it overcome this to work chronically? @MayoClinicCV.
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Want to know how "HFpEFy" your symptomatic patient with dyspnea might be? HFpEF scores quantify myocardial reserve and filling pressure abnormalities across a continuum from health to disease. @MayoClinicCV
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Risk Factors for Contemporary Heart Failure—Respecting the Old (Hypertension) While Accepting the New (Obesity). Hypertension is an important classic cause of HF, but obesity is equally and probably more important on a population level in the modern era.
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RT @RyanTedfordMD: Wrapping up Day 2 of the #CharlestonHFpEF Conference, Dr. Yogesh Reddy from Mayo delivered the best breakdown yet of how….
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Exercise intolerance in HFpEF is almost all about the heart, and little to do with the periphery. Skeletal muscle changes reported are similar to those in multiple other non-HFpEF diseases likely due to heart failure induced sedentariness + deconditioning
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Gp 1 PH with high HFpEF probability have less clinical improvement with traditional PH therapy, compared to gp 1 PH + low HFpEF prob. Do we need more intensive PH therapy, sotatercept or HFpEF therapies for these pts? Many unknowns that need RCTs.
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RT @drbennisahmed: ESC Congress Madrid 2025 . HOT LINE 2 .30 August from 08:15 to 09:45. Vericiguat Global Study in Participants with Chron….
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RT @pabeda1: #ESCCongress2025: Will #vericiguat have a role in chronic heart Failure? VICTOR study will be presented at Hot Line 2 (Did som….
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RT @MichaelAlbertMD: 🧠 Tirzepatide doesn’t just reduce appetite—it rewires the brain. - - -.A new Nature Medicine Phase 1 RCT (n=114) explo….
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Hemodynamic guided and device free interatrial shunting for HFpEF - a simpler approach?.
heart.bmj.com
Elevation in left atrial (LA) pressure is the pathognomonic finding that defines the presence of heart failure with preserved ejection fraction (HFpEF). High LA pressure during exertion is associated...
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Not all weight loss is good in HFpEF. Unintentional weight loss is different than therapeutic weight loss in HFpEF.
onlinelibrary.wiley.com
Clinical significance of unintentional weight loss in heart failure with preserved ejection fraction (HFpEF). BMI, body mass index; CI, confidence interval; HR, hazard ratio; PAWP, pulmonary artery...
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Clinically we use wedge pressure to estimate LA pressure during RHC. In a large transeptal hemodynamic series we show that wedge pressure can be higher than true LAP likely due to pulmonary venous disease and collaterals with implications for PH diagnosis.
academic.oup.com
Accurate estimation of left atrial pressure (LAP) is essential in the management of patients with heart failure (HF), pulmonary hypertension, and valvular
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More evidence that we should be moving away from peak VO2 at max exertion to understand clinically relevant exercise intolerance and patient symptoms. When was the last time a patient wanted to improve their “peak VO2” as opposed to worrying about symptoms during ADLs?.
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Importance of submaximal exercise performance and lactate threshold during early exercise in HFpEF. Early lactate generation linked to hemodynamic and ventilatory differences with early exercise, and not not apparent at peak exertion.
onlinelibrary.wiley.com
Determinants of submaximal exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF). VO2, oxygen consumption.
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More evidence that not all group 1 PH is the same. In the blue journal we show how clinical gp 1 PH with high HFpEF probability is metabolomically distinct from traditional gp 1 PH, and more similar to clinical HFpEF. @ATSBlueEditor @MayoClinicCV
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RT @matslassen: Pooled analysis of obesity and kidney outcomes from 4 HFpEF RCTs now in @JACCJournals . 👥 n=16,919. ⬆️ waist circumference….
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RT @mvaduganathan: 🔥 #CONFIDENCE in @NEJM. Simultaneous initiation of #SGLT2i + #nsMRA safely and rapidly delivers in patients with CKD & T….
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