Yao Rong
@yao_rong5
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Incoming Postdoc in the Yang Lab @Columbia @ColumbiaMPT, PhD in the Spencer Lab @CUBoulder #MCDB #cancerbiology #singlecelldynamics #cancerevolution
Manhattan, NY
Joined October 2016
Check out our new paper led by @paul6589 out now in @Nature. Cells need a boost of energy to jumpstart the cell cycle, but how can this happen while the APC/C is actively inhibiting glycolysis? Cells solve this paradox through a highly dynamic mechanism. https://t.co/XdwY1v3TC9
nature.com
Nature - APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.
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Truly moved and delighted to announce that @chidley_chris and I will open labs this September at @Duke_PCB ! The Darnell lab will be delving deep into how amino acid limitation perturbs the ribosome at specific codons...
We are thrilled to welcome Dr. Alicia Darnell @amcdarnell and Dr. Christopher Chidley @chidley_chris as our newest Assistant Professors š.
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Exciting work led by @YumiKonagaya out in @Nature today. Our paper characterizes a novel #cellcycle state in which E2F is partially active with Rb incompletely phosphorylated, challenging the canonical model of all-or-none E2F activation. @WCMResearch
https://t.co/EUExUlotPw
nature.com
Nature - Cells actively sense external and internal signals to stay quiescent or proliferate, and this trigger relies on being in a reversible primed G1 state of partial retinoblastoma inactivation...
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Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids
cell.com
Amino acids are key inputs for cell growth and proliferation. Using time-lapse single-cell microscopy, Rong etĀ al. found that cell-cycle arrest upon methionine and leucine starvation is mainly...
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Excited to share some of my PhD work in Spencer lab @lab_spencer355 on the control of proliferation versus quiescence by amino acid signaling! Special thanks to my collaborators @amcdarnell @ksapp17 of the @mvh_lab for making this project possible! ā¤ļø
Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids
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Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
cell.com
Selective CDK2 inhibition initially blocks substrate phosphorylation. However, because of a potent positive feedback loop and reinforcement by CDK4/6 activity, cells can rapidly overcome CDK2...
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The Spencer Lab is announcing two job openings, a postdoctoral position in computational or systems biology as well as a lab manager position.
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Excited to share our new work published today! w/ @yao_rong5, Sabrina and Chengzhe ā How do cells decide to proliferate or take a break? 1/n Temporal integration of mitogen history in mother cells controls proliferation of daughter cells
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Matt and I wrote a review on metabolism in the tumor microenvironment that is out now! It was a great opportunity to read and learn more about the metabolism of different tumor stromal cells.
annualreviews.org
Experiments in culture systems where one cell type is provided with abundant nutrients and oxygen have been used to inform much of our understanding of cancer metabolism. However, many differences...
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BREAKING NEWS: The 2019 #NobelPrize in Physiology or Medicine has been awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza āfor their discoveries of how cells sense and adapt to oxygen availability.ā
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Congrats, Min! Great scientist, great mentor!
Congratulations to newly named University of Colorado Distinguished Professor Min Han!
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How does mTOR regulate growth? @DMSabatini describes how he purified and cloned the protein kinase and its role in cell growth and proliferation. https://t.co/gzsrkztn91
#cellbio
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Happening now! Great talks from @AlisonAbridged @Haoxi_xiaozzxi, Eric Olson, Giancarlo, and Elina. About to pick up from lunch with more student talks culminating with our second plenary speaker @theayreslab! Thanks @NIH for supporting our training grant!
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Could clearing senescent cells boost brain function? Senescent cells strikingly increase with age in the brain of neurodegeneration-prone mice, and killing these senescent cells restores cognitive ability. Cool study by the Baker lab! https://t.co/3qh9NubzT8
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Except AKTiniļ¼someone suggested we should also have 'Sabatini', hahaļ½
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Congrats Shuonan!
Pick up the newest issue of @sciencemagazine to read Shuonan He's paper and learn about ancestral roles of Hox genes in tissue segmentation and axial patterning! Congrats Shuonan! https://t.co/jZyYCcb0gU
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In this 3-D video, the latest from Eric Betzig and team, an immune cell migrates inside a zebrafishās inner ear, scooping up particles of sugar (blue) along the way. https://t.co/bUAMFLbl9x
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Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms
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