Orr-El Weizman
@weizmano
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PhD in the lab of @virusesimmunity. Interested in defining the tumor immune interactome. Previous Lab: @SunLab_Official MSKCC studying ILCs
New Haven, CT
Joined June 2009
I am excited to share the last paper from my PhD with @virusimmunity. Here we present TIINDRR (Tumor Immune Non-Biased Discovery Retroviral Reporter). (short thread) 1/
pnas.org
The ability of immune cells to directly interact with transformed cells is an essential component of immune surveillance and critical for optimal t...
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https://t.co/iXtYkQADxZ 🌟Excited to introduce Rho Bio—a startup transforming medicine through lymphatic biology!🚀 We (@aaronmring @VirusesImmunity @jonykipnis and @JennBeecham ) are pioneering new therapies by unlocking the hidden potential of the lymphatic system. 🌿💡
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🚨 🧵 Columbia University, my cherished alma mater, has fallen. Earlier today, Columbia’s Orthodox Rabbi blasted out a WhatsApp message to ~300 Jewish students — a message quite unthinkable in 21st Century America to Jewish people in the city with the most Jewish people in the
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Israel and the Islamic Republic of Iran have been engaged in a shadow war for decades. That changed last night, when Tehran launched an unprecedented direct attack on Israel with more than 300 drones, cruise missiles and ballistic missiles, almost all of which were shot down. The
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Fantastic work from the Song lab!
Excited to share our group's first manuscript describing new anatomical connections that allow the eyes to act as an "immunological window to the brain" 👁️🧠 (1/) https://t.co/mpIEqvZSE5
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Excited to share our group's first manuscript describing new anatomical connections that allow the eyes to act as an "immunological window to the brain" 👁️🧠 (1/) https://t.co/mpIEqvZSE5
nature.com
Nature - A study provides evidence for a shared lymphatic circuit that connects the posterior eye and the brain, allowing the generation of immune responses to protect the CNS against pathogens and...
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Now that we are settled into our new digs at @FredHutch in Seattle, the Ring Lab is expanding! We have 2 #postdoc positions and a research tech position open. See below for links. (1/4)
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🧵Some thoughts after attending today's 47-minute screening of Hamas's atrocities on Oct 7 at the @UN, following a searing speech from @MosabHasanYOSEF - son of one of the co-founders of Hamas.
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A final note: science builds off the work of the others. I am hugely indebted to the work from the labs of Wendell Lim, @KoleRoybal, Zhou Lab, and @victora_lab. Especially to Gabriel for helpful discussions in developing these tools. 5/end
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Grateful to incredible mentors @VirusesImmunity and @aaronmring for their unlimited support & the co-authors who got this over the finish line: Sophie Lyuten, @peowenlu, @ericsongg, Kai Qin, @dariusdariusdar. 4/
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TIINDRR allows for i) a hypothesis-generating approach to interrogate tumor immunity and ii) an expandable platform that is user-adaptable to probe cell-cell interactions. 3/
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We leverage SynNotch receptors to label immune cells that physically interact with tumor cells, allowing us to explore the tumor-immune interactome. We use TIINDRR to interrogate the tumor interactome of different tumors and during various immunotherapies. 2/
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@elife Dear Tara, dear editors: We wish to withdraw our manuscript from editorial consideration at eLife. We are shocked by the recent posts of eLife‘s Editor-in-Chief on X, in which he disparaged the victims of the Hamas terrorist attacks and /1
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Hamas = ISIS Noa is held hostage by Hamas. She could be your daughter, sister, friend. #BringBackOurFamily
Noa was partying in the south of Israel in a peace music festival when Hams terrorists kidnapped her and dragged her from Israel into Gaza. Noa is held hostage by Hamas. She could be your daughter, sister, friend. #BringBackOurFamily
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Well, sure seems like a lot at stake! Mild condescension mixed with a stringent fact based Powerpoint approach making the case for why the family should have a pet.
It is a privilege to make the case that IL-18 is a clear Final 4 contender in the ICIS cytokine tournament. Let me start by paying tribute to its vastly underseeded and plucky opponent, Type III IFN: IFN-III, you have a lot of potential and your time will come!
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It is a privilege to make the case that IL-18 is a clear Final 4 contender in the ICIS cytokine tournament. Let me start by paying tribute to its vastly underseeded and plucky opponent, Type III IFN: IFN-III, you have a lot of potential and your time will come!
Read em and weep. A few thoughts appended. 21 over IFNb will appease @victora_lab @TYewdell @LocciLab while 27 over 6 speaks more to lack of support for 6. At last, the 2 vs 4 matchup may finally produce some sparks in that bracket. 17 vs 1 - meh!
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We are thrilled that our recent study lead by @BayerlFelix is out in @ImmunityCP today. We addressed the question how cDC1 dysfunction is regulated in tumors and to which extent this contributes to cancer immune evasion. It is Open Access!👇 https://t.co/Kjm87tegxm A short 🧵:
cell.com
cDC1s are critical for effective anti-cancer immunity but often dysfunctional in tumors. Bayerl et al. reveal that PGE2 controls cDC1 function locally in tumors through the downregulation of IRF8,...
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#JI_TopRead from @VirusesImmunity @weizmano & colleagues @YaleMed | Conventional type 2 DCs in lungs direct #IFNgamma production by local #NKCells to limit #metastasis | #ReadTheJI #tumorimmunity 👉 https://t.co/EEdXyDV0nz
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The April 15th issue of The Journal of Immunology is now available online! #ReadTheJI 👉 https://t.co/7WPWhjEoJA
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Fantastic new work by @victora_lab adding to the tools deciphering cell-cell interactions!
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