Nicholas Wu
@wchnicholas
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Associate Professor @UofIllinois studying influenza, SARS-CoV-2, antibodies, evolution, and protein structures.
Urbana, IL
Joined December 2014
This preprint just came out. @wchnicholas and team reconstructed and tested the NJ Spike and found that it has the tightest ACE2 binding of any SC2 Spike ever measured. 2/ https://t.co/mwbPmSiBL2
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This is wild. Remember the NJ crytic lineage? I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out. Some colleagues took me up on it. Guess what they found? 1/ https://t.co/0fZyAdHVjj
New Jersey Cryptic lineage update. Background: Cryptic lineages are evolutionarily advanced SARS-CoV-2 lineages detected in wastewater from an unknown source. We are fairly certain that these are derived from patients with persistent SARS-CoV-2 infections. 1/
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Excited to share our recent study (collaborated with @wchnicholas @SolidEvidence) of a wild cryptic lineage, NJ, detected in wastewater. Notably, it carries 39 unique substitutions on the RBD, and exhibits the highest ACE2 binding affinity and extensive antibody evasion.
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Evolution of Ab cross-reactivity to influenza H5N1 NA: Isolation & characterization of protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas
https://t.co/RGeirbNuPj
cell.com
Lv et al. isolated a protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2. Along with structural...
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Evolution of Ab cross-reactivity to influenza H5N1 NA: New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas
https://t.co/RGeirbO2ER
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Excited to share that the oPool⁺ display is on the cover of this week's @ScienceTM! We hope that the future use of this platform can accelerate antibody characterization, benefit therapeutic & vaccine development, and facilitate iterative refinements of antibody AI models.
Don't miss the new issue of #ScienceTranslationalMedicine! A clinical study in Nepal shows that waning immunity to Japanese encephalitis virus can worse the severity of dengue, a new platform leapfrogs laborious obstacles in antibody discovery, and more. https://t.co/XvrMN3JU0s
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Reaching out to senior scientists can feel daunting, but it’s often less intimidating—and more rewarding—than you’d expect. In this @ecrLife article, I share my experience as an early-career researcher and encourage others to take that step too. https://t.co/u8YMIc6gy8
ecrlife.org
When we start out as early career researchers, we often hesitate to reach out to senior scientists. However, they are often excited to help young scientists. Here, Owen Ouyang discusses how mentors...
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New in @JExpMed! 🆕 Researchers alongside Drs. Ali Ellebedy, Nicholas Wu, and @florian_krammer investigated the breadth of anti-NA B cell responses to seasonal #influenza vaccination in humans. 📖 Learn more: https://t.co/6EHVmQyrXS
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We are hiring a highly motivated postdoctoral fellow to study the molecular biology and pathogenesis of enteric viruses that cause diarrhea in human infants. More details on the Ding Lab website - https://t.co/MvydwqZwAW. DM or email me!
sdinglab.wustl.edu
A website by WashU Sites
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In this latest version of the preprint, we are excited to (re)introduce oPool+ display, a high-throughput cell-free platform that enables rapid synthesis and specificity characterization of natively paired antibodies at an unprecedented scale (1/):
biorxiv.org
Antibody discovery is crucial for developing therapeutics and vaccines as well as understanding adaptive immunity. However, the lack of approaches to synthesize antibodies with defined sequences in a...
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I am excited to share our latest work, where we developed oPool+ display, a rapid and cost-approach to synthesize and screen natively paired antibodies in a highly parallel fashion (1/14):
biorxiv.org
Antibody discovery is crucial for developing therapeutics and vaccines as well as understanding adaptive immunity. However, the lack of approaches to synthesize antibodies with defined sequences in a...
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The Ding Lab at the Washington University in St. Louis ( https://t.co/lr1TRzTcH6) is hiring! We are looking for motivated postdocs and technicians to study rotavirus biology and vaccines using viral reverse genetics, mouse models, and human intestinal organoids. Spread the word!
sdinglab.wustl.edu
A website by WashU Sites
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Our paper on SARS-CoV-2 fusion peptide and coronavirus DMS is now available online @NatureComms Great collaboration with @wchnicholas and @RuipengUIUC ! https://t.co/BE9YObLAiI
nature.com
Nature Communications - Deep mutational scanning experiments on an S2 region spanning the fusion peptide of authentic SARS-CoV-2 with different cell lines revealed that mutations at residue 813 of...
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excited to share that our paper on equivariant model for protein structure to function map, led by Mike Pun, is now published in @PNASNews
https://t.co/KQeVDcOs8g
pnas.org
Proteins play a central role in biology from immune recognition to brain activity. While major advances in machine learning have improved our abili...
Check out our new preprint (led by Mike Pun @UW) on 3D rotationally equivariant model of protein structure micro-environments, with a holographic CNN (H-CNN): https://t.co/ER9Ajo7ofy
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I love running, and I love helping people more. In 2024, I want to combine two of my favorite things by running the @ChiMarathon as a @MercyHome hero! Please join me in helping children in need, one step at a time:) #Resolutions2024
https://t.co/xy3rtfVPAe
marathon.mercyhome.org
Join the Mercy Home Heroes charity running team and transform the lives of children in need. in need when you run the 2024 Bank of America Chicago Marathon.
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Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem
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Very nice new paper characterizing anti-N2 mAbs by @wchnicholas and the now twitter-less Ali Ellebedy. Thanks for including my team.
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Three protective Abs that cross-react with neuraminidases from seasonal H3N2 strains spanning multiple decades with implications for developing broadly protective influenza vaccines @wchnicholas @ImmunityCP
https://t.co/W23U2fK1aQ
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